GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **651 - 675** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲
FLT3 Signaling	Bcl-2-like protein 11 Cyclin-dependent kinase inhibitor 1B Fms-related tyrosine kinase 3 ligand Forkhead box protein O3 GRB2-associated-binding protein 2 GRB2-related adapter protein 2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 10 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor-type tyrosine-protein kinase FLT3 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	O43521 O43524 O75791 P01111 P01112 P27986 P31749 P31751 P36888 P42336 P46527 P49771 Q06124 Q07889 Q13322 Q9UQC2 Q9Y243	AKT1 AKT2 AKT3 BCL2L11 BIM CD135 CDKN1B FKHRL1 FLK2 FLT3 FLT3LG FOXO3 FOXO3A GAB2 GADS GRAP2 GRB1 GRB10 GRB2L GRBIR GRID HRAS HRAS1 KIAA0207 KIAA0571 KIP1 NRAS PIK3CA PIK3R1 PKB PKBG PTP2C PTPN11 RAC SHPTP2 SOS1 STK1 p27
Regulation of TP53 Activity through Acetylation	Bromodomain and PHD finger-containing protein 3 Bromodomain-containing protein 1 Bromodomain-containing protein 7 Cellular tumor antigen p53 Chromatin modification-related protein MEAF6 Chromodomain-helicase-DNA-binding protein 3 Chromodomain-helicase-DNA-binding protein 4 Histone acetyltransferase KAT6A Histone acetyltransferase p300 Histone deacetylase 1 Histone deacetylase 2 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Inhibitor of growth protein 5 Metastasis-associated protein MTA2 Methyl-CpG-binding domain protein 3 Peregrin Protein PML RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Transcriptional repressor p66-alpha Transcriptional repressor p66-beta	O94776 O95696 O95983 P04637 P29590 P31749 P31751 P55201 Q09028 Q09472 Q12873 Q13547 Q14839 Q16576 Q86YP4 Q8WXI9 Q8WYH8 Q92769 Q92794 Q9HAF1 Q9NPI1 Q9ULD4 Q9Y243	AKT1 AKT2 AKT3 BP75 BR140 BRD1 BRD7 BRL BRPF1 BRPF2 BRPF3 C1orf149 CELTIX1 CENP-28 CHD3 CHD4 EAF6 EP300 GATAD2A GATAD2B HDAC1 HDAC2 ING5 KAT6A KIAA1150 KIAA1286 MBD3 MEAF6 MOZ MTA1L1 MTA2 MYL MYST3 P300 P53 PID PKB PKBG PML PP8675 RAC RBAP46 RBAP48 RBBP4 RBBP7 RNF71 RPD3L1 RUNXBP2 TP53 TRIM19 ZNF220
VEGFR2 mediated vascular permeability	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Cadherin-5 Calmodulin-1 Catenin alpha-1 Catenin beta-1 Catenin delta-1 Caveolin-1 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Heat shock protein HSP 90-alpha Junction plakoglobin Membrane protein Nitric oxide synthase 3 Nucleoprotein Proline-rich protein 5 Proto-oncogene vav RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Ras-related C3 botulinum toxin substrate 1 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase mTOR Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3	O15530 O60716 O75914 P07900 P0DP23 P0DTC5 P0DTC9 P14923 P15498 P29474 P31749 P31751 P33151 P35221 P35222 P42345 P52735 P63000 P85299 Q03135 Q13153 Q13177 Q5T1C6 Q6R327 Q96RU7 Q9BPZ7 Q9BVC4 Q9UKW4 Q9Y243	AKT1 AKT2 AKT3 C20orf97 CALM CALM1 CAM CAM1 CAV CAV1 CDH5 CTMP CTNNA1 CTNNB CTNNB1 CTNND1 CTNNG DP3 FRAP FRAP1 FRAP2 GBL HSP90A HSP90AA1 HSPC1 HSPCA JUP KIAA0384 KIAA1999 LST8 M MAPKAP1 MIP1 MLST8 MTOR N NIPK NOS3 OPHN3 PAK1 PAK2 PAK3 PDK1 PDPK1 PKB PKBG PROTOR1 PRR5 RAC RAC1 RAFT1 RAPT1 RICTOR SIN1 SKIP3 TC25 THEM4 TRB3 TRIB3 VAV VAV1 VAV2 VAV3
CD28 dependent PI3K/Akt signaling	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Membrane protein Mitogen-activated protein kinase kinase kinase 14 Mitogen-activated protein kinase kinase kinase 8 Nucleoprotein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proline-rich protein 5 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Serine/threonine-protein kinase mTOR T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck	O00459 O15530 P06239 P06241 P0DTC5 P0DTC9 P10747 P27986 P31749 P31751 P33681 P41279 P42081 P42336 P42345 P85299 Q5T1C6 Q6R327 Q92569 Q96RU7 Q99558 Q9BPZ7 Q9BVC4 Q9Y243	AKT1 AKT2 AKT3 C20orf97 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 COT CTMP ESTF FRAP FRAP1 FRAP2 FYN GBL GRB1 KIAA1999 LAB7 LCK LST8 M MAP3K14 MAP3K8 MAPKAP1 MIP1 MLST8 MTOR N NIK NIPK PDK1 PDPK1 PIK3CA PIK3R1 PIK3R2 PIK3R3 PKB PKBG PROTOR1 PRR5 RAC RAFT1 RAPT1 RICTOR SIN1 SKIP3 THEM4 TRB3 TRIB3
Negative regulation of the PI3K/AKT network	Acyl-coenzyme A thioesterase THEM4 PH domain leucine-rich repeat-containing protein phosphatase 1 PH domain leucine-rich repeat-containing protein phosphatase 2 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Tribbles homolog 3	O60346 P31749 P31751 P60484 Q5T1C6 Q6ZVD8 Q96RU7 Q9Y243	AKT1 AKT2 AKT3 C20orf97 CTMP KIAA0606 KIAA0931 MMAC1 NIPK PHLPP PHLPP1 PHLPP2 PHLPPL PKB PKBG PLEKHE1 PTEN RAC SCOP SKIP3 TEP1 THEM4 TRB3 TRIB3
RUNX2 regulates genes involved in cell migration	Collagenase 3 Core-binding factor subunit beta Integrin alpha-5 Integrin beta-like protein 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase	O95965 P08648 P31749 P31751 P45452 Q13951 Q9Y243	AKT1 AKT2 AKT3 CBFB FNRA ITGA5 ITGBL1 MMP13 OSCP PKB PKBG RAC TIED
CTLA4 inhibitory signaling	Cytotoxic T-lymphocyte protein 4 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes Tyrosine-protein phosphatase non-receptor type 11	P06239 P06241 P07947 P07948 P16410 P30153 P30154 P31749 P31751 P33681 P42081 P62714 P67775 Q06124 Q13362 Q14738 Q15172 Q15173 Q16537 Q9Y243	AKT1 AKT2 AKT3 CD152 CD28LG CD28LG1 CD28LG2 CD80 CD86 CTLA4 FYN JTK8 KIAA0044 LAB7 LCK LYN PKB PKBG PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTP2C PTPN11 RAC SHPTP2 YES YES1
Downregulation of ERBB2:ERBB3 signaling	E3 ubiquitin-protein ligase NRDP1 Polyubiquitin-B Polyubiquitin-C Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor tyrosine-protein kinase erbB-2 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14511 P04626 P0CG47 P0CG48 P31749 P31751 P40818 P62979 P62987 Q02297 Q9H4P4 Q9Y243	AKT1 AKT2 AKT3 ERBB2 FLRF GGF HER2 HGL HRGA KIAA0055 MLN19 NDF NEU NGL NRDP1 NRG1 NRG2 NTAK PKB PKBG RAC RNF41 RPS27A SMDF UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBPY USP8
AKT-mediated inactivation of FOXO1A	Forkhead box protein O1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase	P31749 P31751 Q12778 Q9Y243	AKT1 AKT2 AKT3 FKHR FOXO1 FOXO1A PKB PKBG RAC
Deactivation of the beta-catenin transactivating complex	14-3-3 protein zeta/delta Adenomatous polyposis coli protein B-cell CLL/lymphoma 9 protein B-cell CLL/lymphoma 9-like protein Beta-catenin-interacting protein 1 C-terminal-binding protein 1 Catenin beta-1 Chromodomain-helicase-DNA-binding protein 8 E3 ubiquitin-protein ligase XIAP Exportin-1 F-box/WD repeat-containing protein 1A Histone deacetylase 1 Histone-lysine N-methyltransferase 2D Lymphoid enhancer-binding factor 1 Menin Polyubiquitin-B Polyubiquitin-C Protein chibby homolog 1 Pygopus homolog 1 Pygopus homolog 2 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase Retinoblastoma-binding protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 Sex-determining region Y protein Transcription factor 7-like 1 Transcription factor 7-like 2 Transcription factor 7 Transcription factor SOX-13 Transcription factor SOX-17 Transcription factor SOX-2 Transcription factor SOX-3 Transcription factor SOX-4 Transcription factor SOX-6 Transcription factor SOX-7 Transcription factor SOX-9 Transducin-like enhancer protein 1 Transducin-like enhancer protein 2 Transducin-like enhancer protein 3 Transducin-like enhancer protein 4 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00255 O00512 O14686 O14980 P0CG47 P0CG48 P25054 P31749 P31751 P35222 P35712 P36402 P41225 P48431 P48436 P62979 P62987 P63104 P98170 Q04724 Q04725 Q04726 Q04727 Q05066 Q06945 Q13363 Q13547 Q15291 Q86UU0 Q9BRQ0 Q9BT81 Q9H6I2 Q9HCK8 Q9HCS4 Q9NQB0 Q9NSA3 Q9UBL3 Q9UJU2 Q9UN79 Q9Y297 Q9Y3M2 Q9Y3Y4	AKT1 AKT2 ALR APC API3 ARB1 ASH2L ASH2L1 BCL9 BCL9L BIRC4 BTRC BTRCP C22orf2 CBY CBY1 CHD8 CRM1 CTBP CTBP1 CTNNB CTNNB1 CTNNBIP1 DLNB11 DP2.5 FBW1A FBXW1A GRG4 HDAC1 HELSNF1 IAP3 ICAT KIAA1261 KIAA1547 KIAA1564 KMT2D LEF1 MEN1 MLL2 MLL4 PGEA1 PKB PYGO1 PYGO2 RAC RBBP5 RBQ3 RPD3L1 RPS27A SCG2 SOX13 SOX17 SOX2 SOX3 SOX4 SOX6 SOX7 SOX9 SRY TCF1 TCF3 TCF4 TCF7 TCF7L1 TCF7L2 TDF TLE1 TLE2 TLE3 TLE4 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 XIAP XPO1 YWHAZ
Translocation of SLC2A4 (GLUT4) to the plasma membrane	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 C2 domain-containing protein 5 Calmodulin-1 Exocyst complex component 1 Exocyst complex component 2 Exocyst complex component 3 Exocyst complex component 4 Exocyst complex component 5 Exocyst complex component 6 Exocyst complex component 7 Exocyst complex component 8 Kinesin-associated protein 3 Kinesin-like protein KIF3A Kinesin-like protein KIF3B Leucyl-cystinyl aminopeptidase Myosin-9 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase Ral GTPase-activating protein subunit alpha-2 Ral GTPase-activating protein subunit beta Ras-related C3 botulinum toxin substrate 1 Ras-related protein Rab-10 Ras-related protein Rab-11A Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-4A Ras-related protein Rab-8A Ras-related protein Ral-A Rho-related GTP-binding protein RhoQ Solute carrier family 2, facilitated glucose transporter member 4 Synaptosomal-associated protein 23 Syntaxin-4 Syntaxin-binding protein 3 TBC1 domain family member 1 TBC1 domain family member 4 Tether containing UBX domain for GLUT4 Unconventional myosin-Ic Unconventional myosin-Va Vesicle-associated membrane protein 2	O00159 O00161 O00186 O00471 O15066 O43741 O60343 O60645 P0DP23 P11233 P14672 P17081 P20338 P27348 P31749 P31751 P31946 P31947 P35579 P51153 P54619 P54646 P61006 P61026 P61106 P61981 P62258 P62491 P63000 P63027 P63104 Q04917 Q12846 Q2PPJ7 Q86TI0 Q86X10 Q86YS7 Q8IYI6 Q8TAG9 Q92845 Q96A65 Q96KP1 Q9BZE9 Q9NV70 Q9UGI9 Q9UGJ0 Q9UIQ6 Q9UPT5 Q9Y478 Q9Y496 Q9Y4I1	AKT1 AKT2 AMPK AMPK2 AMPKG3 ARHQ AS160 ASPL ASPSCR1 C20orf74 C2CD5 CALM CALM1 CAM CAM1 CDP138 EXO70 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 GLUT4 HME1 KIAA0359 KIAA0528 KIAA0603 KIAA1067 KIAA1108 KIAA1219 KIAA1272 KIAA1699 KIF3 KIF3A KIF3AP KIF3B KIFAP3 LNPEP MEL MYH12 MYH9 MYO1C MYO5A OTASE PKB PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAB10 RAB11 RAB11A RAB13 RAB14 RAB4 RAB4A RAB8 RAB8A RAC RAC1 RAL RALA RALGAPA2 RALGAPB RASL7A RCC17 RHOQ SEC10 SEC10L1 SEC15A SEC15L SEC15L1 SEC3 SEC3L1 SEC5 SEC5L1 SEC6 SEC6L1 SEC8 SEC8L1 SFN SLC2A4 SMAP SNAP23 STX4 STX4A STXBP3 SYB2 TBC1D1 TBC1D4 TC10 TC25 TUG UBXD9 UBXN9 VAMP2 YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Interleukin-4 and Interleukin-13 signaling	72 kDa type IV collagenase Amine oxidase [flavin-containing] A Annexin A1 Apoptosis regulator Bcl-2 B-cell lymphoma 6 protein Baculoviral IAP repeat-containing protein 5 Basic leucine zipper transcriptional factor ATF-like Bcl-2-like protein 1 C-C motif chemokine 22 C-C motif chemokine 2 CCAAT/enhancer-binding protein delta Cellular tumor antigen p53 Coagulation factor XIII A chain Collagen alpha-2(I) chain Cyclin-dependent kinase inhibitor 1 Cytokine receptor common subunit gamma Delta-type opioid receptor Endoplasmin Eotaxin Fascin Fibroblast growth factor 2 Fibronectin Forkhead box protein O1 Forkhead box protein O3 G1/S-specific cyclin-D1 Heat shock cognate 71 kDa protein Heat shock protein HSP 90-alpha Heme oxygenase 1 Hepatocyte growth factor Homeobox protein NANOG Hypoxia-inducible factor 1-alpha Immunoglobulin heavy constant epsilon Immunoglobulin heavy constant gamma 1 Immunoglobulin heavy constant gamma 4 Induced myeloid leukemia cell differentiation protein Mcl-1 Integrin alpha-M Integrin alpha-X Integrin beta-1 Integrin beta-2 Intercellular adhesion molecule 1 Interferon regulatory factor 4 Interleukin-1 alpha Interleukin-1 beta Interleukin-10 Interleukin-12 subunit alpha Interleukin-12 subunit beta Interleukin-13 receptor subunit alpha-1 Interleukin-13 receptor subunit alpha-2 Interleukin-13 Interleukin-17A Interleukin-17F Interleukin-18 Interleukin-23 receptor Interleukin-23 subunit alpha Interleukin-4 receptor subunit alpha Interleukin-4 Interleukin-6 receptor subunit alpha Interleukin-6 Interleukin-8 Interstitial collagenase Laminin subunit alpha-5 Leukemia inhibitory factor Lipopolysaccharide-binding protein Low affinity immunoglobulin epsilon Fc receptor Matrix metalloproteinase-9 Metalloproteinase inhibitor 1 Mu-type opioid receptor Mucin-1 Myc proto-oncogene protein Necdin Neutrophil gelatinase-associated lipocalin Nitric oxide synthase, inducible Non-receptor tyrosine-protein kinase TYK2 Nuclear receptor ROR-alpha Nuclear receptor ROR-gamma Oncostatin-M POU domain, class 2, transcription factor 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Platelet glycoprotein 4 Polyunsaturated fatty acid 5-lipoxygenase Polyunsaturated fatty acid lipoxygenase ALOX15 Pro-opiomelanocortin Prostaglandin G/H synthase 2 Protein c-Fos RAC-alpha serine/threonine-protein kinase Rho-related GTP-binding protein RhoU Serine/threonine-protein kinase pim-1 Serum amyloid A-1 protein Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 6 Sphingosine 1-phosphate receptor 1 Stromelysin-1 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Suppressor of cytokine signaling 5 Trans-acting T-cell-specific transcription factor GATA-3 Transcription factor JunB Transcription factor SOX-2 Transforming growth factor beta-1 proprotein Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor receptor superfamily member 1B Tumor necrosis factor Twist-related protein 1 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Vascular cell adhesion protein 1 Vascular endothelial growth factor A, long form Vimentin Zinc finger E-box-binding homeobox 1	O00626 O14543 O15230 O15392 O15524 O43524 O60674 O75159 P00488 P01033 P01100 P01106 P01137 P01189 P01375 P01583 P01584 P01854 P01857 P01861 P02751 P03956 P04083 P04637 P05107 P05112 P05231 P05362 P05556 P06734 P07900 P08123 P08253 P08254 P08670 P08887 P09038 P09601 P09917 P0DJI8 P10145 P10415 P11142 P11215 P11309 P13500 P13725 P14210 P14625 P14780 P14859 P15018 P15692 P15941 P16050 P16671 P17275 P18428 P19320 P20333 P20702 P21397 P21453 P22301 P23458 P23771 P24385 P24394 P27986 P29459 P29460 P29597 P31749 P31785 P35225 P35228 P35354 P35372 P35398 P37275 P38936 P40763 P41143 P41182 P42224 P42226 P48023 P48431 P49716 P51449 P51671 P52333 P78552 P80188 Q07817 Q07820 Q12778 Q14116 Q14627 Q15306 Q15672 Q16520 Q16552 Q16658 Q16665 Q5VWK5 Q7L0Q8 Q96PD4 Q99608 Q9H9S0 Q9NPF7	AKT1 ALOX15 ALOX5 ANX1 ANXA1 API4 APRF APT1LG1 AREB6 ARHU BATF BCL1 BCL2 BCL2L BCL2L1 BCL2L3 BCL5 BCL6 BCLX BHLHA38 BHLHE39 BHLHE78 BIRC5 CAP20 CCL11 CCL2 CCL22 CCND1 CD11B CD11C CD18 CD23A CD36 CD95L CDC42L1 CDKN1 CDKN1A CEBPD CHEDG1 CIP1 CIS3 CIS6 CISH5 CISH6 CLEC4J CLG CLG4A CLG4B CLGI COL1A2 COX2 CR3A CTLA8 CXCL8 EDG1 F13A F13A1 FAN1 FASL FASLG FCE2 FCER2 FGF2 FGFB FKHR FKHRL1 FN FN1 FNRB FOS FOXO1 FOXO1A FOXO3 FOXO3A FSCN1 G0S7 G28K GATA3 GP3B GP4 GRB1 GRP94 HGF HIF1A HILDA HMOX1 HNL HO HO1 HPTA HSC70 HSN HSP73 HSP90A HSP90AA1 HSP90B1 HSPA10 HSPA8 HSPC1 HSPC4 HSPCA IAP4 ICAM1 IFNB2 IGEBF IGHE IGHG1 IGHG4 IGIF IL10 IL12A IL12B IL13 IL13R IL13RA IL13RA1 IL13RA2 IL17 IL17A IL17F IL18 IL1A IL1B IL1F1 IL1F2 IL1F4 IL23A IL23R IL2RG IL4 IL4R IL4RA IL6 IL6R IL8 IRF4 ITGAM ITGAX ITGB1 ITGB2 JAK1 JAK1A JAK1B JAK2 JAK3 JUNB KIAA0533 KIAA0671 KIAA1907 LAMA5 LAZ3 LBP LCN2 LIF LOG15 LOG5 LPC1 MAOA MCL1 MCP1 MDA6 MDC MDF2 MFI7 MMP1 MMP2 MMP3 MMP9 MOP1 MOR1 MSK12 MUC1 MUM1 MYC NANOG NC30 NDN NGAL NKSF1 NKSF2 NOS2 NOS2A NR1F1 NR1F3 OCT1 OPRD OPRD1 OPRM1 OSM OTF1 P53 PASD8 PIC1 PIK3R1 PIM1 PKB POMC POU2F1 PRAD1 PTGS2 PUM RAC RHOU RORA RORC RORG RZRA RZRG S1PR1 SAA1 SCYA11 SCYA2 SCYA22 SDI1 SGRF SNL SOCS1 SOCS3 SOCS5 SOX2 SSI1 SSI3 STAT1 STAT3 STAT6 STMY1 TCF8 TGFB TGFB1 TIMP TIMP1 TIP3 TNF TNFA TNFBR TNFR2 TNFRSF1B TNFSF2 TNFSF6 TP53 TRA1 TWIST TWIST1 TYK2 VCAM1 VEGF VEGFA VIM WAF1 WRCH1 ZBTB27 ZEB1 ZNF51
Integrin signaling	3-phosphoinositide-dependent protein kinase 1 Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin Focal adhesion kinase 1 Integrin alpha-IIb Integrin beta-3 Proto-oncogene tyrosine-protein kinase Src RAC-alpha serine/threonine-protein kinase RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 2 Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 Ras-related protein Rap-1A Ras-related protein Rap-1b SHC-transforming protein 1 Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase SYK Tyrosine-protein phosphatase non-receptor type 1 von Willebrand factor	O15530 O95267 O95398 P02671 P02675 P02679 P02751 P04275 P05106 P08514 P12931 P18031 P29353 P31749 P41240 P43405 P61224 P62834 Q05397 Q7LDG7 Q7Z5R6 Q8WZA2 Q9Y490	AKT1 APBB1IP CDC25L CGEF1 CGEF2 CSK EPAC EPAC1 EPAC2 F8VWF FAK FAK1 FGA FGB FGG FN FN1 GP2B GP3A ITGA2B ITGAB ITGB3 KIAA1027 KREV1 MCG7 PDK1 PDPK1 PKB PREL1 PTK2 PTP1B PTPN1 RAC RAP1A RAP1B RAPGEF3 RAPGEF4 RARP1 RASGRP RASGRP1 RASGRP2 RIAM SHC SHC1 SHCA SRC SRC1 SYK TLN TLN1 VWF
eNOS activation	Acyl-protein thioesterase 1 Calmodulin-1 Caveolin-1 Cytoglobin Heat shock protein HSP 90-alpha N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Nitric oxide synthase 3 Palmitoyltransferase ZDHHC21 RAC-alpha serine/threonine-protein kinase Sepiapterin reductase	O75608 O94760 P07900 P0DP23 P29474 P31749 P35270 Q03135 Q8IVQ6 Q8WWM9	AKT1 APT1 CALM CALM1 CAM CAM1 CAV CAV1 CYGB DDAH DDAH1 HSP90A HSP90AA1 HSPC1 HSPCA LPL1 LYPLA1 NOS3 PKB RAC SPR STAP ZDHHC21
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 Docking protein 1 E3 ubiquitin-protein ligase CBL Polyubiquitin-B Polyubiquitin-C Protein-tyrosine kinase 6 RAC-alpha serine/threonine-protein kinase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG47 P0CG48 P22681 P31749 P62979 P62987 Q13882 Q96P48 Q99704	AKT1 ARAP1 BRK CBL CBL2 CENTD2 DOK1 KIAA0782 PKB PTK6 RAC RNF55 RPS27A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Amphiregulin B-lymphocyte antigen CD19 Beta-klotho Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin receptor Insulin Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-like 1 Interleukin-33 Mast/stem cell growth factor receptor Kit Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Myeloid differentiation primary response protein MyD88 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 beta Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphoinositide 3-kinase adapter protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase Radiation-inducible immediate-early gene IEX-1 Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Rho-related GTP-binding protein RhoG Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Striatin T-cell receptor-associated transmembrane adapter 1 T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 TNF receptor-associated factor 6 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 11	O00329 O00459 O14511 O14944 O14986 O15520 O43320 O43815 O60331 O76093 O95750 O95760 P00533 P01127 P01133 P01135 P01308 P03372 P04626 P05230 P06213 P06239 P06241 P08581 P08620 P09038 P09619 P10721 P10747 P10767 P11487 P12931 P14210 P15153 P15391 P15498 P15514 P16234 P21781 P22455 P27361 P27986 P28482 P30153 P30154 P31371 P31749 P33681 P35070 P35568 P36888 P42081 P42336 P42338 P46695 P48426 P49771 P51617 P56975 P62714 P63000 P67775 P78356 P84095 Q01638 Q02297 Q06124 Q13362 Q13480 Q14738 Q15172 Q15173 Q16537 Q6PIZ9 Q6UW88 Q6ZUJ8 Q86Z14 Q8TBX8 Q8WU20 Q8WWG1 Q92569 Q92731 Q99075 Q99755 Q99836 Q9GZV9 Q9HCT0 Q9NP95 Q9NWZ3 Q9UQC2 Q9Y4H2 Q9Y4K3	AKT1 AREG AREGB ARHG BCAP BTC C9orf26 CD135 CD19 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 DER4 DIF2 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ERK1 ERK2 ESR ESR1 ESR2 ESTRB FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 FYN GAB1 GAB2 GGF GRB1 HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRGA HST HST2 HSTF1 HSTF2 HYPF IER3 IEX1 IL1F11 IL1RL1 IL33 INS INSR INT2 IRAK IRAK1 IRAK4 IRS1 IRS2 JTK2 KGF KIAA0044 KIAA0571 KIAA0589 KIT KLB KS3 LAB7 LCK MAPK1 MAPK3 MET MLN19 MYD88 NDF NEU NFHEV NGL NR3A1 NR3A2 NRG1 NRG2 NRG3 NRG4 NTAK PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PI5P4KA PIK3AP1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PIP5K2 PIP5K2A PIP5K2B PIP5K2C PKB PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRG1 PRKM1 PRKM2 PRKM3 PTP2C PTPN11 RAC RAC1 RAC2 RHEPDGFRA RHOG RNF85 SCFR SDGF SHPTP2 SIS SMDF SRC SRC1 ST2 STK1 STM7 STRN T1 TC25 TCRIM TGFA TKF TRAF6 TRAT1 VAV VAV1
Extra-nuclear estrogen signaling	72 kDa type IV collagenase Amphiregulin Calmodulin-1 Caveolin-1 Caveolin-2 Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Focal adhesion kinase 1 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(i) subunit alpha-1 Guanine nucleotide-binding protein G(i) subunit alpha-2 Guanine nucleotide-binding protein G(i) subunit alpha-3 Guanine nucleotide-binding protein G(t) subunit alpha-3 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Heat shock protein HSP 90-alpha Insulin-like growth factor 1 receptor Matrilysin Matrix metalloproteinase-9 Nitric oxide synthase 3 Palmitoyltransferase ZDHHC21 Palmitoyltransferase ZDHHC7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein arginine N-methyltransferase 1 Proto-oncogene tyrosine-protein kinase Src Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase Sphingosine 1-phosphate receptor 3 Sphingosine kinase 1 Striatin Stromelysin-1	A8MTJ3 O00459 O14610 O14775 O14944 O43815 O60262 P00533 P01133 P01135 P03372 P04899 P07900 P08069 P08253 P08254 P08754 P09237 P0DP23 P12931 P14780 P15514 P16520 P27986 P29474 P31749 P35070 P42336 P50150 P50151 P51636 P59768 P61952 P62873 P62879 P63096 P63211 P63215 P63218 Q03135 Q05397 Q6UW88 Q8IVQ6 Q92569 Q92731 Q99075 Q99500 Q99873 Q9HAV0 Q9NXF8 Q9NYA1 Q9P2W3 Q9UBI6 Q9UK08	AKT1 AREG AREGB BTC C9orf108 C9orf47 CALM CALM1 CAM CAM1 CAV CAV1 CAV2 CLG4A CLG4B DTR DTS EDG3 EGF EGFR EPGN ERBB ERBB1 EREG ESR ESR1 ESR2 ESTRB FAK FAK1 GNAI1 GNAI2 GNAI2B GNAI3 GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 GRB1 HBEGF HEGFL HER1 HMT2 HRMT1L2 HSP90A HSP90AA1 HSPC1 HSPCA IGF1R IR1B4 MMP2 MMP3 MMP7 MMP9 MPSL1 NOS3 NR3A1 NR3A2 PIK3CA PIK3R1 PIK3R2 PIK3R3 PKB PRMT1 PTK2 PUMP1 RAC S1PR3 SDGF SK1 SPHK SPHK1 SPK SRC SRC1 STMY1 STRN TGFA ZDHHC21 ZDHHC7
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	14-3-3 protein beta/alpha 5'-3' exoribonuclease 1 Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP42 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP44 MAP kinase-activated protein kinase 2 RAC-alpha serine/threonine-protein kinase m7GpppN-mRNA hydrolase mRNA decay activator protein ZFP36L1 mRNA-decapping enzyme 1A	P31749 P31946 P49137 Q06265 Q07352 Q13868 Q15024 Q5RKV6 Q8IU60 Q8IZH2 Q96B26 Q9NPD3 Q9NPI6 Q9NQT4 Q9NQT5 Q9Y2L1 Q9Y3B2	AKT1 BERG36 BRF1 CML28 CSL4 DCP1A DCP2 DIS3 ERF1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 KIAA0116 KIAA1008 MAPKAPK2 MTR3 NUDT20 OIP2 PKB PMSCL1 RAC RNF162B RRP4 RRP40 RRP41 RRP42 RRP43 RRP44 RRP46 SEP1 SKI6 SMIF TIS11B XRN1 YWHAB ZFP36L1
Negative regulation of NOTCH4 signaling	14-3-3 protein zeta/delta 26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-1 E3 ubiquitin-protein ligase RBX1 Neurogenic locus notch homolog protein 4 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-10 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 RAC-alpha serine/threonine-protein kinase S-phase kinase-associated protein 1 Transforming acidic coiled-coil-containing protein 3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00231 O00232 O00233 O00487 O14818 O43242 O75832 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P31749 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62877 P62979 P62987 P63104 P63208 Q06323 Q13200 Q13616 Q15008 Q16401 Q92530 Q99436 Q99460 Q99466 Q9UL46 Q9UNM6 Q9Y6A5	AKT1 C7orf76 CUL1 DSS1 EMC19 ERIC1 HC2 HC3 HC8 HC9 HSPC IFI5111 INT3 KIAA0072 KIAA0107 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NOTCH4 NU OCP2 PFAAP4 PKB POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSMF1 RAC RBX1 RING10 RING12 RNF75 ROC1 RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A SUG1 SUG2 TACC3 TBP1 TBP7 TCEB1L TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 YWHAZ Z
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	6-pyruvoyl tetrahydrobiopterin synthase Calmodulin-1 Dihydrofolate reductase GTP cyclohydrolase 1 feedback regulatory protein GTP cyclohydrolase 1 Heat shock protein HSP 90-alpha Nitric oxide synthase 3 RAC-alpha serine/threonine-protein kinase Sepiapterin reductase cGMP-dependent protein kinase 2	P00374 P07900 P0DP23 P29474 P30047 P30793 P31749 P35270 Q03393 Q13237	AKT1 CALM CALM1 CAM CAM1 DHFR DYT5 GCH GCH1 GCHFR GFRP HSP90A HSP90AA1 HSPC1 HSPCA NOS3 PKB PRKG2 PRKGR2 PTS RAC SPR
KSRP (KHSRP) binds and destabilizes mRNA	14-3-3 protein zeta/delta Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP42 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP44 Far upstream element-binding protein 2 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Poly(A)-specific ribonuclease PARN RAC-alpha serine/threonine-protein kinase m7GpppN-mRNA hydrolase	O95453 P31749 P63104 Q06265 Q13868 Q15024 Q15759 Q16539 Q5RKV6 Q8IU60 Q92945 Q96B26 Q9NPD3 Q9NQT4 Q9NQT5 Q9Y2L1 Q9Y3B2	AKT1 CML28 CSBP CSBP1 CSBP2 CSL4 CSPB1 DAN DCP2 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FUBP2 KHSRP KIAA0116 KIAA1008 MAPK11 MAPK14 MTR3 MXI2 NUDT20 OIP2 PARN PKB PMSCL1 PRKM11 RAC RRP4 RRP40 RRP41 RRP42 RRP43 RRP44 RRP46 SAPK2 SAPK2A SAPK2B SKI6 YWHAZ
mTORC1-mediated signalling	14-3-3 protein beta/alpha Eukaryotic elongation factor 2 kinase Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4B Eukaryotic translation initiation factor 4E-binding protein 1 Eukaryotic translation initiation factor 4E GTP-binding protein Rheb Neutral amino acid transporter 9 Peptidyl-prolyl cis-trans isomerase FKBP1A Proline-rich AKT1 substrate 1 Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Ribosomal protein S6 kinase beta-1 Serine/threonine-protein kinase mTOR Small ribosomal subunit protein eS6 Target of rapamycin complex subunit LST8	O00418 O43504 P06730 P23443 P23588 P31946 P42345 P62753 P62942 Q04637 Q0VGL1 Q13541 Q15382 Q5VZM2 Q6IAA8 Q7L523 Q8N122 Q8NBW4 Q96B36 Q9BVC4 Q9HB90 Q9NQL2 Q9UHA4 Q9Y2Q5	AKT1S1 C11orf59 C7orf59 EEF2K EIF4B EIF4E EIF4EBP1 EIF4EL1 EIF4F EIF4G EIF4G1 EIF4GI FKBP1 FKBP12 FKBP1A FRAP FRAP1 FRAP2 GBL HBXIP KIAA1303 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MTOR PDRO PRAS40 RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPS6 RPS6KB1 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 STK14A URLC11 XIP YWHAB
HSF1-dependent transactivation	Alpha-crystallin B chain Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma DnaJ homolog subfamily B member 1 Heat shock 70 kDa protein 1-like Heat shock 70 kDa protein 1A Heat shock 70 kDa protein 1B Heat shock cognate 71 kDa protein Heat shock factor protein 1 Heat shock factor-binding protein 1 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Heat shock protein beta-8 Proline-rich AKT1 substrate 1 Regulatory-associated protein of mTOR Serine/threonine-protein kinase mTOR Target of rapamycin complex subunit LST8	O75506 P02511 P07900 P08238 P0DMV8 P0DMV9 P11142 P25685 P34931 P42345 Q00613 Q13554 Q13555 Q13557 Q8N122 Q96B36 Q9BVC4 Q9UJY1 Q9UQM7	AKT1S1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CRYA2 CRYAB CRYAC DNAJ1 DNAJB1 E2IG1 FRAP FRAP1 FRAP2 GBL HDJ1 HSBP1 HSC70 HSF1 HSF1BP HSP22 HSP72 HSP73 HSP90A HSP90AA1 HSP90AB1 HSP90B HSPA1 HSPA10 HSPA1A HSPA1B HSPA1L HSPA8 HSPB5 HSPB8 HSPC1 HSPC2 HSPC3 HSPCA HSPCB HSPF1 HSTF1 HSX70 KIAA0968 KIAA1303 LST8 MLST8 MTOR PRAS40 RAFT1 RAPT1 RAPTOR RPTOR
Activation of PKB	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 RAC-beta serine/threonine-protein kinase Tribbles homolog 3	O15530 P31751 Q5T1C6 Q96RU7	AKT2 C20orf97 CTMP NIPK PDK1 PDPK1 SKIP3 THEM4 TRB3 TRIB3
Inhibition of TSC complex formation by PKB	Hamartin RAC-beta serine/threonine-protein kinase Tuberin	P31751 P49815 Q92574	AKT2 KIAA0243 TSC TSC1 TSC2 TSC4

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