Frs2-mediated activation
|
|
|
- BRAF
- BRAF1
- CRKL
- ERK1
- ERK2
- FRS2
- GRF2
- KREV1
- MAP2K1
- MAP2K2
- MAPK1
- MAPK3
- MEK1
- MEK2
- MKK2
- NGF
- NGFB
- PRKM1
- PRKM2
- PRKM3
- PRKMK1
- PRKMK2
- RAFB1
- RAP1A
- RAPGEF1
- YWHAB
|
|
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
|
|
|
- APRF
- CRIPTO
- CRIPTO-1
- DPPA4
- EPH
- EPHA1
- EPHT
- EPHT1
- FGF2
- FGFB
- FOXD3
- HFH2
- NANOG
- OCT3
- OCT4
- OTF3
- POU5F1
- SAL1
- SALL1
- SALL4
- SOX2
- STAT3
- TDGF1
- ZIC3
- ZNF203
- ZNF794
- ZNF797
|
|
Mitochondrial protein degradation
|
- 2-oxoglutarate dehydrogenase complex component E1
- 3-hydroxyacyl-CoA dehydrogenase type-2
- 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- 5-aminolevulinate synthase, non-specific, mitochondrial
- 60 kDa heat shock protein, mitochondrial
- ADP/ATP translocase 2
- ADP/ATP translocase 3
- ATP synthase subunit O, mitochondrial
- ATP synthase subunit a
- ATP synthase subunit alpha, mitochondrial
- ATP synthase subunit beta, mitochondrial
- ATP synthase subunit d, mitochondrial
- ATP synthase subunit g, mitochondrial
- ATP synthase subunit gamma, mitochondrial
- ATP synthase-coupling factor 6, mitochondrial
- ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
- ATP-dependent Clp protease proteolytic subunit, mitochondrial
- ATP-dependent zinc metalloprotease YME1L1
- Acetyl-CoA acetyltransferase, mitochondrial
- Aconitate hydratase, mitochondrial
- Acyl-coenzyme A thioesterase 2, mitochondrial
- Aldehyde dehydrogenase X, mitochondrial
- Aldehyde dehydrogenase, mitochondrial
- Arginase-2, mitochondrial
- Calcium uptake protein 2, mitochondrial
- Citrate synthase, mitochondrial
- Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome c oxidase subunit 1
- Cytochrome c oxidase subunit 2
- Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
- Cytochrome c oxidase subunit 5B, mitochondrial
- D-beta-hydroxybutyrate dehydrogenase, mitochondrial
- Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
- Delta-1-pyrroline-5-carboxylate synthase
- Dihydrolipoyl dehydrogenase, mitochondrial
- Dynamin-like GTPase OPA1, mitochondrial
- Enoyl-CoA delta isomerase 1, mitochondrial
- Essential MCU regulator, mitochondrial
- Ferrochelatase, mitochondrial
- Fumarate hydratase, mitochondrial
- Glutamate dehydrogenase 1, mitochondrial
- Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
- Isobutyryl-CoA dehydrogenase, mitochondrial
- Isocitrate dehydrogenase [NADP], mitochondrial
- Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
- Isoleucine--tRNA ligase, mitochondrial
- Large ribosomal subunit protein bL12m
- Large ribosomal subunit protein bL32m
- Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
- Lon protease homolog, mitochondrial
- Malate dehydrogenase, mitochondrial
- Metalloendopeptidase OMA1, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim10
- Mitochondrial import inner membrane translocase subunit Tim17-A
- Mitochondrial import inner membrane translocase subunit Tim22
- Mitochondrial import inner membrane translocase subunit Tim9
- Mitochondrial inner membrane m-AAA protease component AFG3L2
- Mitochondrial inner membrane m-AAA protease component paraplegin
- Mitochondrial-processing peptidase subunit alpha
- NAD kinase 2, mitochondrial
- NAD-dependent malic enzyme, mitochondrial
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
- NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
- NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 2
- NADH-ubiquinone oxidoreductase chain 5
- NADH-ubiquinone oxidoreductase chain 6
- PRELI domain-containing protein 1, mitochondrial
- Probable D-lactate dehydrogenase, mitochondrial
- Propionyl-CoA carboxylase beta chain, mitochondrial
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Serine hydroxymethyltransferase, mitochondrial
- Serine protease HTRA2, mitochondrial
- Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
- Single-stranded DNA-binding protein, mitochondrial
- Small ribosomal subunit protein uS10m
- Small ribosomal subunit protein uS2m
- StAR-related lipid transfer protein 7, mitochondrial
- Steroidogenic acute regulatory protein, mitochondrial
- Stress-70 protein, mitochondrial
- Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
- Succinyl-CoA
- TP53-regulated inhibitor of apoptosis 1
- Transcription factor A, mitochondrial
- Twinkle mtDNA helicase
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
- cAMP-dependent protein kinase catalytic subunit alpha
|
|
- 15E1.1
- AAC2
- AAC3
- ACAD8
- ACADSB
- ACAT
- ACAT1
- ACO2
- ACOT2
- AFG3L2
- ALAS1
- ALAS3
- ALASH
- ALDH18A1
- ALDH1B1
- ALDH2
- ALDH5
- ALDHX
- ALDM
- ANT2
- ANT3
- ARC42
- ARG2
- ATP5A
- ATP5A1
- ATP5AL2
- ATP5B
- ATP5C
- ATP5C1
- ATP5CL1
- ATP5F1A
- ATP5F1B
- ATP5F1C
- ATP5H
- ATP5J
- ATP5L
- ATP5MG
- ATP5O
- ATP5PD
- ATP5PF
- ATP5PO
- ATP6
- ATPASE6
- ATPM
- ATPMB
- ATPO
- ATPSB
- BCATE2
- BCKDHE2
- BDH
- BDH1
- C10orf2
- C22orf32
- C5orf33
- C7orf17
- CAR
- CHCHD2
- CLPP
- CLPX
- CMAR
- COI
- COII
- COX2
- COX4
- COX4I1
- COX5A
- COX5B
- COXI
- COXII
- CS
- DBT
- DCI
- DLD
- ECH1
- ECI1
- EFHA1
- EMRE
- ERAB
- FECH
- FH
- FTSH1
- GCSL
- GLUD
- GLUD1
- GRIM19
- GRP75
- GSAS
- GTT1
- HAD
- HAD1
- HADH
- HADH2
- HADHSC
- HMGCS2
- HSD17B10
- HSP60
- HSPA9
- HSPA9B
- HSPD1
- HTRA2
- IARS2
- IBD
- IDH2
- IDH3A
- INPP5E
- KIAA0123
- KIAA0567
- LAD
- LDHD
- LONP1
- MAT
- MDH2
- ME2
- MICU2
- MIMT17
- MNADK
- MPPA
- MPRP1
- MRPL12
- MRPL32
- MRPL7
- MRPP2
- MRPS10
- MRPS2
- MT-ATP6
- MT-CO1
- MT-CO2
- MT-ND1
- MT-ND2
- MT-ND5
- MT-ND6
- MTATP6
- MTCO1
- MTCO2
- MTND1
- MTND2
- MTND5
- MTND6
- NADH1
- NADH2
- NADH5
- NADH6
- NADK2
- NADKD1
- ND1
- ND2
- ND5
- ND6
- NDUFA13
- NDUFA2
- NDUFB6
- NDUFS1
- NDUFS3
- NDUFV1
- NDUFV3
- OGDH
- OMA1
- OMI
- OPA1
- OXCT
- OXCT1
- OXSM
- P5CS
- PCCB
- PDHA1
- PDHB
- PDHK1
- PDK1
- PEO1
- PGN
- PHE1A
- PHE1B
- PHE3
- PKACA
- PMPCA
- PRELI
- PRELID1
- PRKACA
- PRSS15
- PRSS25
- PTE2
- PTE2A
- PYCS
- RPML12
- SCHAD
- SCOT
- SDR5C1
- SDR9C1
- SHMT2
- SLC25A5
- SLC25A6
- SMDT1
- SPG7
- SSBP
- SSBP1
- STAR
- STARD1
- STARD7
- SUCLG2
- TCF6
- TCF6L2
- TEX4
- TFAM
- TIM10
- TIM17
- TIM17A
- TIM22
- TIM9
- TIM9A
- TIMM10
- TIMM17
- TIMM17A
- TIMM22
- TIMM9
- TIMM9A
- TRIAP1
- TWNK
- UQCRC2
- UQCRQ
- UQOR1
- XH98G2
- YME1L
- YME1L1
- mt-HSP70
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Beta oxidation of butanoyl-CoA to acetyl-CoA
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|
|
- ACADS
- ACSM3
- ACSM6
- C10orf129
- ECHS1
- HAD
- HAD1
- HADH
- HADHSC
- SAH
- SCHAD
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Lysosomal oligosaccharide catabolism
|
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- KIAA0935
- LAMAN
- MAN2B1
- MAN2B2
- MAN2C1
- MANA
- MANA1
- MANB
- MANB1
- MANBA
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HS-GAG degradation
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|
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- AGRIN
- AGRN
- ELNR1
- GLB1
- GLB1L
- GLB1L2
- GLB1L3
- GPC1
- GPC2
- GPC3
- GPC4
- GPC5
- GPC6
- GUSB
- HEP
- HPA
- HPA1
- HPA2
- HPR1
- HPSE
- HPSE1
- HPSE2
- HSE1
- HSPG1
- HSPG2
- HSS
- IDS
- IDUA
- KIAA0468
- NAGLU
- OCI5
- SDC
- SDC1
- SDC2
- SDC3
- SDC4
- SGSH
- SIDS
- UFHSD1
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N-glycan trimming in the ER and Calnexin/Calreticulin cycle
|
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- AMFR
- DER1
- DERL1
- ENGASE
- G19P1
- G2AN
- GANAB
- GCS1
- HEL-220
- HEL-S-70
- KIAA0088
- KIAA0152
- MLEC
- MOGS
- NGLY1
- PNG1
- PRKCSH
- PSMC1
- RAD23B
- RNF45
- RPS27A
- SAKS1
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UBXN1
- VCP
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Keratan sulfate degradation
|
|
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- ACAN
- AGC1
- CSPG1
- ELNR1
- FM
- FMOD
- GLB1
- GLB1L
- GLB1L2
- GLB1L3
- GNS
- HEXA
- HEXB
- KERA
- LDC
- LUM
- MSK16
- OGN
- OIF
- OMD
- PRELP
- SLRR2A
- SLRR2B
- SLRR2C
- SLRR2D
- SLRR2E
- SLRR3A
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Glycosphingolipid catabolism
|
|
|
- ARSA
- ARSB
- ARSC1
- ARSD
- ARSE
- ARSF
- ARSG
- ARSH
- ARSI
- ARSJ
- ARSK
- ARSL
- ASAH
- ASAH1
- ASAH2
- ASM
- CBG
- CBGL1
- CTSA
- ELNR1
- ENPP7
- GALC
- GBA
- GBA1
- GBA2
- GBA3
- GC
- GLA
- GLB1
- GLB1L
- GLB1L2
- GLB1L3
- GLBA
- GLUC
- GM2A
- HEXA
- HEXB
- HNAC1
- KIAA1001
- KIAA1418
- KIAA1605
- M6PR
- MPR46
- MPRD
- NANH
- NEU1
- NEU2
- NEU3
- PPGB
- PSAP
- SAP1
- SKNY
- SMPD1
- SMPD2
- SMPD3
- SMPD4
- SPG46
- STS
- SUMF1
- SUMF2
- TSULF
|
|
Defective HEXA causes GM2G1
|
|
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Defective HEXB causes GM2G2
|
|
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|
|
Scavenging by Class A Receptors
|
|
|
- APOA1
- APOB
- APOE
- CALR
- CLP1
- COL1A1
- COL1A2
- COL3A1
- COL4A1
- COL4A2
- COLEC11
- COLEC12
- CRARF
- CRARF1
- CRTC
- FTH
- FTH1
- FTHL6
- FTL
- GRP94
- HSP90B1
- HSPC4
- MARCO
- MASP1
- MSR1
- NSR2
- PNSP1
- PRSS5
- SCARA1
- SCARA2
- SCARA4
- SCARA5
- SCGB3A2
- SRCL
- TRA1
- UGRP1
|
|
CS/DS degradation
|
|
|
- ARSB
- BCAN
- BEHAB
- BGN
- CALEB
- CSPG2
- CSPG3
- CSPG4
- CSPG5
- CSPG7
- DCN
- HEXA
- HEXB
- HYAL1
- HYAL3
- IDS
- IDUA
- LUCA1
- LUCA3
- MCSP
- NCAN
- NEUR
- NGC
- SIDS
- SLRR1A
- SLRR1B
- VCAN
|
|
Pentose phosphate pathway
|
|
|
- CARKL
- DERA
- G6PD
- PGD
- PGDH
- PGLS
- PGM2
- RBKS
- RBSK
- RPE
- RPEL1
- RPI
- RPIA
- SHPK
- TAL
- TALDO
- TALDO1
- TALDOR
- TKT
|
|
Hyaluronan uptake and degradation
|
|
|
- APNH1
- CD44
- CHP
- CHP1
- CRSBP1
- FEEL2
- FELL
- FEX2
- GUSB
- HAR
- HARE
- HEXA
- HEXB
- HMMR
- HYAL1
- HYAL2
- HYAL3
- IHABP
- LHR
- LUCA1
- LUCA2
- LUCA3
- LYVE1
- MDU2
- MDU3
- MIC4
- NHE1
- RHAMM
- SLC9A1
- STAB2
- XLKD1
|
|
MPS IX - Natowicz syndrome
|
|
|
|
|
Hyaluronan biosynthesis and export
|
|
|
- ABCC5
- CEMIP
- HAS
- HAS1
- HAS2
- HAS3
- HYBID
- KIAA1199
- MRP5
|
|
MPS VII - Sly syndrome
|
|
|
|
|
Lewis blood group biosynthesis
|
- 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6
- Alpha-(1,3)-fucosyltransferase 10
- Alpha-(1,3)-fucosyltransferase 11
- Alpha-(1,3)-fucosyltransferase 4
- Alpha-(1,3)-fucosyltransferase 7
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
- Beta-1,3-galactosyltransferase 1
- Beta-1,3-galactosyltransferase 2
- Beta-1,3-galactosyltransferase 4
- Beta-1,3-galactosyltransferase 5
- Beta-1,4 N-acetylgalactosaminyltransferase 2
- CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
- Galactoside alpha-(1,2)-fucosyltransferase 2
- Type 2 lactosamine alpha-2,3-sialyltransferase
|
|
- B3GALT1
- B3GALT2
- B3GALT4
- B3GALT5
- B4GALNT2
- CGS23
- ELFT
- FCT3A
- FT3B
- FUT10
- FUT11
- FUT2
- FUT3
- FUT4
- FUT5
- FUT6
- FUT7
- FUT9
- GALGT2
- GALT4
- LE
- NANTA3
- SEC2
- SIAT10
- SIAT4C
- SIAT6
- SIAT7F
- ST3GAL3
- ST3GAL4
- ST3GAL6
- ST6GALNAC6
- STZ
|
|
Reversible DNA damage induced by alkylating chemotherapeutic drugs
|
|
|
|
|
Alkylating DNA damage induced by chemotherapeutic drugs
|
|
|
|
|
Ficolins bind to repetitive carbohydrate structures on the target cell surface
|
|
|
- CRARF
- CRARF1
- FCN1
- FCN2
- FCN3
- FCNH
- FCNL
- FCNM
- HAKA1
- MASP1
- PRSS5
|
|
Lectin pathway of complement activation
|
|
|
- CLL1
- COLEC1
- COLEC10
- COLEC11
- CRARF
- CRARF1
- FCN1
- FCN2
- FCN3
- FCNH
- FCNL
- FCNM
- HAKA1
- MASP1
- MBL
- MBL2
- PRSS5
|
|
Initial triggering of complement
|
|
|
- C1QA
- C1QB
- C1QC
- C1QG
- C1R
- C1S
- C2
- C4A
- C4B
- C4B_2
- CLL1
- CO4
- COLEC1
- COLEC10
- COLEC11
- CPAMD2
- CPAMD3
- CRARF
- CRARF1
- FCN1
- FCN2
- FCN3
- FCNH
- FCNL
- FCNM
- HAKA1
- IGHG1
- IGHG2
- IGHG3
- IGHG4
- IGHV
- IGHV1-2
- IGHV1-46
- IGHV1-69
- IGHV2-5
- IGHV2-70
- IGHV3-11
- IGHV3-13
- IGHV3-23
- IGHV3-30
- IGHV3-33
- IGHV3-48
- IGHV3-53
- IGHV3-7
- IGHV3-9
- IGHV4-34
- IGHV4-39
- IGHV4-59
- IGHV7-81
- IGKC
- IGKV1-12
- IGKV1-16
- IGKV1-17
- IGKV1-33
- IGKV1-39
- IGKV1-5
- IGKV1D-12
- IGKV1D-16
- IGKV1D-33
- IGKV1D-39
- IGKV2-28
- IGKV2-29
- IGKV2-30
- IGKV2D-28
- IGKV2D-30
- IGKV2D-40
- IGKV3-11
- IGKV3-15
- IGKV3-20
- IGKV3D-20
- IGKV4-1
- IGKV5-2
- IGLC1
- IGLC2
- IGLC3
- IGLC6
- IGLC7
- IGLV
- IGLV1-40
- IGLV1-44
- IGLV1-47
- IGLV1-51
- IGLV2-11
- IGLV2-14
- IGLV2-23
- IGLV2-8
- IGLV3-1
- IGLV3-19
- IGLV3-21
- IGLV3-25
- IGLV3-27
- IGLV6-57
- IGLV7-43
- MASP1
- MBL
- MBL2
- PRSS5
- V1-11
- V1-13
- V1-16
- V1-20
- V1-3
- V1-5
- V1-7
- V1-9
- V2-11
- V2-15
- V2-17
- V2-19
- V2-8
- V3-2
- V3-3
- V3-4
- V4-1
- V4-2
- V4-6
- V5-1
- V5-4
- V5-6
|
|
Antimicrobial peptides
|
|
|
- AIDD
- APOJ
- BPI
- BPIFA1
- BPIFA2
- BPIFB1
- BPIFB2
- BPIFB4
- BPIFB6
- BPIL1
- BPIL3
- C20orf114
- C20orf184
- C20orf186
- C20orf70
- CAMP
- CAP18
- CHGA
- CLI
- CLU
- CTSG
- DCD
- DSEP
- ECP
- ELA2
- ELANE
- EPPIN
- FALL39
- GIG12
- GNLY
- HIP
- HIS1
- HIS2
- HS71
- HSP70
- HTN1
- HTN3
- INTL
- ITLN
- ITLN1
- KUB1
- LAG2
- LEAP2
- LF
- LFR
- LPLUNC1
- LPLUNC2
- LPLUNC4
- LTF
- LUNX
- LYZ
- LZM
- MBN
- NASG
- NKG5
- PAP
- PAP1
- PAP1B
- PGLYRP
- PGLYRP1
- PGLYRP2
- PGLYRP3
- PGLYRP4
- PGLYRPL
- PGRP
- PGRPIA
- PGRPIB
- PGRPL
- PI3
- PLA2B
- PLA2G2A
- PLA2L
- PLUNC
- PRSS2
- PRSS3
- PRSS4
- PRTN3
- RASF-A
- REG3A
- REG3G
- RNASE3
- RNASE6
- RNASE7
- RNASE8
- RNS3
- RNS6
- SEMG
- SEMG1
- SPINLW1
- SPLUNC1
- SPLUNC2
- SPURT
- SSA1
- SSA2
- SSA4
- TLA519
- TNFSF3L
- TRY2
- TRY3
- TRY4
- TRYP2
- WAP3
- WAP7
- WFDC14
- WFDC7
|
|