GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **301 - 325** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▲
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin and metalloproteinase domain-containing protein 17 Neurogenic locus notch homolog protein 1 Protein jagged-1 Protein jagged-2	O00548 O14672 P46531 P78504 P78536 Q9NR61 Q9Y219	ADAM10 ADAM17 CSVP DLL1 DLL4 JAG1 JAG2 JAGL1 KUZ MADM NOTCH1 TACE TAN1	Homo sapiens (human)
Chromatin modifying enzymes	Bromodomain and WD repeat-containing protein 1 Histone H3.1 Histone H3.2 Protein-arginine deiminase type-1 Protein-arginine deiminase type-2 Protein-arginine deiminase type-3 Protein-arginine deiminase type-4 Protein-arginine deiminase type-6 Transcription activator BRG1	P51532 P68431 Q6TGC4 Q71DI3 Q9NSI6 Q9ULC6 Q9ULW8 Q9UM07 Q9Y2J8	BAF190A BRG1 BRWD1 C21orf107 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST2H3A HIST2H3C HIST2H3D KIAA0994 PAD1 PAD2 PAD3 PAD4 PAD6 PADI1 PADI2 PADI3 PADI4 PADI5 PADI6 PDI1 PDI2 PDI3 PDI5 SMARCA4 SNF2B SNF2L4 WDR9	Homo sapiens (human)
VxPx cargo-targeting to cilium	ADP-ribosylation factor 4 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Cyclic nucleotide-gated channel alpha-2 Cyclic nucleotide-gated channel alpha-4 Cyclic nucleotide-gated channel beta-1 Exocyst complex component 1 Exocyst complex component 2 Exocyst complex component 3 Exocyst complex component 4 Exocyst complex component 5 Exocyst complex component 6 Exocyst complex component 7 Exocyst complex component 8 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 Polycystin-1 Polycystin-2 Rab-3A-interacting protein Rab11 family-interacting protein 3 Ras-related protein Rab-11A Ras-related protein Rab-8A Rhodopsin	O00471 O60645 O75154 P08100 P18085 P61006 P62491 P98161 Q13563 Q14028 Q16280 Q8IV77 Q8IYI6 Q8TAG9 Q92538 Q96A65 Q96KP1 Q96QF0 Q9NV70 Q9ULH1 Q9UPT5	ARF2 ARF4 ARFO1 ASAP1 CNCA CNCA1 CNCG2 CNCG3L CNCG4 CNGA2 CNGA4 CNGB1 DDEF1 EXO70 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 GBF1 KIAA0248 KIAA0665 KIAA1067 KIAA1249 KIAA1699 MEL OPN2 PAG2 PKD1 PKD2 RAB11 RAB11A RAB11FIP3 RAB3IP RAB8 RAB8A RABIN8 RCNC2 RHO SEC10 SEC10L1 SEC15A SEC15L SEC15L1 SEC3 SEC3L1 SEC5 SEC5L1 SEC6 SEC6L1 SEC8 SEC8L1 TRPP2	Homo sapiens (human)
SCF-beta-TrCP mediated degradation of Emi1	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cell division cycle protein 20 homolog Cullin-1 F-box only protein 5 F-box/WD repeat-containing protein 1A Fizzy-related protein homolog Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 S-phase kinase-associated protein 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00231 O00232 O00233 O00487 O14818 O43242 O75832 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62979 P62987 P63208 Q06323 Q12834 Q13200 Q13616 Q14997 Q15008 Q16401 Q8TAA3 Q92530 Q99436 Q99460 Q9UKT4 Q9UL46 Q9UM11 Q9UNM6 Q9Y297	BTRC BTRCP C7orf76 CDC20 CDH1 CUL1 DSS1 EMC19 EMI1 FBW1A FBX5 FBXO5 FBXW1A FYR FZR FZR1 HC2 HC3 HC8 HC9 HSPC IFI5111 KIAA0072 KIAA0077 KIAA0107 KIAA1242 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NU OCP2 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RING10 RING12 RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A SUG1 SUG2 TBP1 TBP7 TCEB1L TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 Z	Homo sapiens (human)
Estrogen biosynthesis	17-beta-hydroxysteroid dehydrogenase 14 17-beta-hydroxysteroid dehydrogenase type 1 17-beta-hydroxysteroid dehydrogenase type 2 Aldo-keto reductase family 1 member B15 Aromatase Estradiol 17-beta-dehydrogenase 11	C9JRZ8 P11511 P14061 P37059 Q8NBQ5 Q9BPX1	AKR1B15 ARO1 CYAR CYP19 CYP19A1 DHRS10 DHRS8 E17KSR EDH17B1 EDH17B2 EDHB17 HSD17B1 HSD17B11 HSD17B14 HSD17B2 PAN1B SDR16C2 SDR28C1 SDR3 SDR47C1 SDR9C2	Homo sapiens (human)
VEGFR2 mediated vascular permeability	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Cadherin-5 Calmodulin-1 Catenin alpha-1 Catenin beta-1 Catenin delta-1 Caveolin-1 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Heat shock protein HSP 90-alpha Junction plakoglobin Membrane protein Nitric oxide synthase 3 Nucleoprotein Proline-rich protein 5 Proto-oncogene vav RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Ras-related C3 botulinum toxin substrate 1 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase mTOR Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3	O15530 O60716 O75914 P07900 P0DP23 P0DTC5 P0DTC9 P14923 P15498 P29474 P31749 P31751 P33151 P35221 P35222 P42345 P52735 P63000 P85299 Q03135 Q13153 Q13177 Q5T1C6 Q6R327 Q96RU7 Q9BPZ7 Q9BVC4 Q9UKW4 Q9Y243	AKT1 AKT2 AKT3 C20orf97 CALM CALM1 CAM CAM1 CAV CAV1 CDH5 CTMP CTNNA1 CTNNB CTNNB1 CTNND1 CTNNG DP3 FRAP FRAP1 FRAP2 GBL HSP90A HSP90AA1 HSPC1 HSPCA JUP KIAA0384 KIAA1999 LST8 M MAPKAP1 MIP1 MLST8 MTOR N NIPK NOS3 OPHN3 PAK1 PAK2 PAK3 PDK1 PDPK1 PKB PKBG PROTOR1 PRR5 RAC RAC1 RAFT1 RAPT1 RICTOR SIN1 SKIP3 TC25 THEM4 TRB3 TRIB3 VAV VAV1 VAV2 VAV3	Homo sapiens (human)
TWIK-related spinal cord K+ channel (TRESK)	Potassium channel subfamily K member 18	Q7Z418	KCNK18 TRESK TRIK	Homo sapiens (human)
Defective cofactor function of FVIIIa variant	Coagulation factor IX Coagulation factor VIII Coagulation factor X	P00451 P00740 P00742	F10 F8 F8C F9	Homo sapiens (human)
RUNX2 regulates chondrocyte maturation	Core-binding factor subunit beta Histone deacetylase 4 Indian hedgehog protein Zinc finger protein GLI2	P10070 P56524 Q13951 Q14623	CBFB GLI2 HDAC4 IHH KIAA0288 THP	Homo sapiens (human)
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	Cullin-1 E3 ubiquitin-protein ligase RBX1 Neurogenic locus notch homolog protein 1 S-phase kinase-associated protein 1	P46531 P62877 P63208 Q13616	CUL1 EMC19 NOTCH1 OCP2 RBX1 RNF75 ROC1 SKP1 SKP1A TAN1 TCEB1L	Homo sapiens (human)
NOTCH3 Intracellular Domain Regulates Transcription	CREB-binding protein Disks large-associated protein 5 Fatty acid-binding protein, brain Hairy/enhancer-of-split related with YRPW motif protein 1 Hairy/enhancer-of-split related with YRPW motif protein 2 Hairy/enhancer-of-split related with YRPW motif-like protein Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase p300 Mastermind-like domain-containing protein 1 Mastermind-like protein 1 Mastermind-like protein 2 Mastermind-like protein 3 Neurogenic locus notch homolog protein 1 Neurogenic locus notch homolog protein 3 Plexin-D1 Pre T-cell antigen receptor alpha Pre-B-cell leukemia transcription factor 1 Protein KIBRA Recombining binding protein suppressor of hairless SNW domain-containing protein 1 Signal transducer and activator of transcription 1-alpha/beta Transcription factor HES-1 Transcription factor HES-5	O15540 P40424 P42224 P46531 Q06330 Q09472 Q13495 Q13573 Q14469 Q15398 Q5TA89 Q6ISU1 Q8IX03 Q8IZL2 Q92585 Q92793 Q92830 Q92831 Q96JK9 Q9NQ87 Q9UBP5 Q9UM47 Q9Y4D7 Q9Y5J3	BHLHB31 BHLHB32 BHLHB33 BHLHB38 BHLHB39 BLBP CBP CG1 CHF1 CHF2 CREBBP CXorf6 DLG7 DLGAP5 EP300 FABP7 FABPB GCN5 GCN5L2 GRL HERP HERP1 HERP2 HES1 HES5 HESR1 HEY1 HEY2 HEYL HL HRT1 HRT2 HRT3 HRY IGKJRB IGKJRB1 KAT2A KAT2B KIAA0008 KIAA0200 KIAA0620 KIAA0869 KIAA1816 KIAA1819 KIBRA MAML1 MAML2 MAML3 MAMLD1 MRG NOTCH1 NOTCH3 P300 PBX1 PCAF PLXND1 PRL PTCRA RBPJ RBPJK RBPSUH SKIIP SKIP SNW1 STAT1 TAN1 WWC1	Homo sapiens (human)
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Bone morphogenetic protein 7 Chromodomain-helicase-DNA-binding protein 3 Chromodomain-helicase-DNA-binding protein 4 Cytochrome c oxidase subunit 7A1, mitochondrial Heterogeneous nuclear ribonucleoprotein U Histone deacetylase 1 Histone deacetylase 2 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase PRDM16 Lipid transferase CIDEA Metastasis-associated protein MTA1 Metastasis-associated protein MTA2 Metastasis-associated protein MTA3 Methyl-CpG-binding domain protein 3 Mitochondrial brown fat uncoupling protein 1 Mothers against decapentaplegic homolog 1 Mothers against decapentaplegic homolog 4 Nuclear receptor coactivator 1 Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Peroxisome proliferator-activated receptor gamma coactivator 1-beta Peroxisome proliferator-activated receptor gamma Retinoic acid receptor RXR-alpha Transcription factor COE2 Transcriptional repressor p66-alpha Transcriptional repressor p66-beta Type II iodothyronine deiodinase Very long chain fatty acid elongase 3 Zinc finger protein 423	O60543 O94776 O95983 P18075 P19793 P24310 P25874 P37231 Q00839 Q07869 Q09028 Q12873 Q13330 Q13485 Q13547 Q14839 Q15788 Q15797 Q16576 Q2M1K9 Q86YN6 Q86YP4 Q8WXI9 Q92769 Q92813 Q9BTC8 Q9HAK2 Q9HAZ2 Q9HB03 Q9UBK2	BHLHE74 BMP7 BSP1 C1orf199 CHD3 CHD4 CIDEA CIG30 COE2 COX7A1 COX7AH DIO2 DPC4 EBF2 ELOVL3 GATAD2A GATAD2B HDAC1 HDAC2 HNRNPU HNRPU ITDI2 KIAA0760 KIAA1150 KIAA1266 KIAA1675 LEM6 MADH1 MADH4 MADR1 MBD3 MEL1 MTA1 MTA1L1 MTA2 MTA3 NCOA1 NPHP14 NR1C1 NR1C3 NR2B1 OAZ OP1 PERC PFM13 PGC1 PGC1A PGC1B PID PPAR PPARA PPARG PPARGC1 PPARGC1A PPARGC1B PRDM16 RBAP46 RBAP48 RBBP4 RBBP7 RPD3L1 RXRA SAFA SLC25A7 SMAD1 SMAD4 SRC1 TXDI2 U21.1 UCP UCP1 ZNF423	Homo sapiens (human)
HDACs deacetylate histones	AT-rich interactive domain-containing protein 4A AT-rich interactive domain-containing protein 4B Breast cancer metastasis-suppressor 1 Chromodomain-helicase-DNA-binding protein 3 Chromodomain-helicase-DNA-binding protein 4 F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 G protein pathway suppressor 2 Histone H2A type 1-A Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-H Histone H2A type 1-J Histone H2A type 1 Histone H2A type 2-A Histone H2A type 2-B Histone H2A type 2-C Histone H2A type 3 Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 2-F Histone H2B type 3-B Histone H3.1 Histone H3.2 Histone H4 Histone deacetylase 1 Histone deacetylase 2 Histone deacetylase 3 Histone deacetylase 8 Histone deacetylase complex subunit SAP18 Histone deacetylase complex subunit SAP30 Histone deacetylase complex subunit SAP30L Histone-binding protein RBBP4 Histone-binding protein RBBP7 Lysine-specific histone demethylase 1A Metastasis-associated protein MTA1 Metastasis-associated protein MTA2 Metastasis-associated protein MTA3 Methyl-CpG-binding domain protein 3 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 PHD finger protein 21A Polyamine deacetylase HDAC10 RE1-silencing transcription factor REST corepressor 1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related Sin3 histone deacetylase corepressor complex component SDS3 Transcriptional repressor p66-alpha Transcriptional repressor p66-beta	O00422 O15379 O60341 O60814 O60907 O75376 O75446 O94776 O95983 P04908 P06899 P0C0S8 P20671 P23527 P29374 P33778 P58876 P62805 P62807 P68431 Q09028 Q12873 Q13127 Q13227 Q13330 Q13547 Q14839 Q16576 Q16777 Q16778 Q4LE39 Q5QNW6 Q6FI13 Q71DI3 Q7L7L0 Q86YP4 Q8IUE6 Q8N257 Q8WXI9 Q92769 Q93077 Q93079 Q969S8 Q96A08 Q96BD5 Q96KK5 Q96QV6 Q99877 Q99878 Q99879 Q99880 Q9BTC8 Q9BY41 Q9BZK7 Q9H7L9 Q9HAJ7 Q9HCU9 Q9P0W2 Q9UKL0 Q9Y618	AOF2 ARID4A ARID4B BHC80 BRAF35 BRCAA1 BRMS1 CHD3 CHD4 CTG26 GATAD2A GATAD2B GPS2 H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFC H2AFD H2AFE H2AFG H2AFI H2AFL H2AFM H2AFN H2AFO H2AFP H2AFQ H2AFR H2AW H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC18 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFT H2BU1 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HDAC1 HDAC10 HDAC2 HDAC3 HDAC8 HDACL1 HIRIP1 HIRIP2 HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AG HIST1H2AH HIST1H2AI HIST1H2AJ HIST1H2AK HIST1H2AL HIST1H2AM HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AB HIST2H2AC HIST2H2BE HIST2H2BF HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2A HIST3H2BB HIST4H4 HMG20B HMGX2 HMGXB2 IRA1 KDM1 KDM1A KIAA0071 KIAA0601 KIAA1047 KIAA1150 KIAA1266 KIAA1696 LSD1 MBD3 MTA1 MTA1L1 MTA2 MTA3 NCOR1 NCOR2 NRSF NS4ATP2 PHF21A PID RBAP46 RBAP48 RBBP1 RBBP1L1 RBBP4 RBBP7 RBP1 RBP1L1 RCOR RCOR1 REST RPD3L1 SAP18 SAP180 SAP30 SAP30L SAP45 SDS3 SMARCE1R SUDS3 TBL1 TBL1X TBL1XR1 TBLR1 TSH2B XBR	Homo sapiens (human)
Defective UGT1A4 causes hyperbilirubinemia	UDP-glucuronosyltransferase 1A4	P22310	GNT1 UGT1 UGT1A4	Homo sapiens (human)
Negative regulators of RIG-I/MDA5 signaling	Antiviral innate immune response receptor RIG-I Autophagy protein 5 E3 ISG15--protein ligase HERC5 E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin-protein ligase RNF125 E3 ubiquitin-protein ligase RNF135 E3 ubiquitin-protein ligase RNF216 E3 ubiquitin-protein ligase TRIM4 E3 ubiquitin/ISG15 ligase TRIM25 Inhibitor of nuclear factor kappa-B kinase subunit epsilon Interferon regulatory factor 3 Interferon-induced helicase C domain-containing protein 1 Mitochondrial antiviral-signaling protein NLR family member X1 OTU domain-containing protein 5 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Poly(rC)-binding protein 2 Polyubiquitin-B Polyubiquitin-C Protein NLRC5 Serine/threonine-protein kinase TBK1 TNF receptor-associated factor 3 Tax1-binding protein 1 Tumor necrosis factor alpha-induced protein 3 Ubiquitin carboxyl-terminal hydrolase CYLD Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-conjugating enzyme E2 K Ubiquitin-like modifier-activating enzyme 7 Ubiquitin-like protein ATG12 Ubiquitin-like protein ISG15 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Ubiquitin/ISG15-conjugating enzyme E2 L6	O14933 O94817 O95786 P05161 P0CG47 P0CG48 P21580 P41226 P51668 P61077 P61086 P62837 P62979 P62987 Q13114 Q13526 Q14164 Q14258 Q14653 Q15366 Q7Z434 Q86UT6 Q86VP1 Q86WI3 Q8IUD6 Q96EQ8 Q96G74 Q96J02 Q9BYX4 Q9C037 Q9H1Y0 Q9NQC7 Q9NWF9 Q9UHD2 Q9UII4	APG12 APG12L APG5L ASP ATG12 ATG5 CAP-1 CEB1 CEBP1 CRAF1 CYLD CYLD1 DDX58 EFP G1P2 HERC5 HIP2 IFIH1 IKBKE IKKE IKKI IPS1 IRF3 ISG15 ITCH KIAA0151 KIAA0849 KIAA1271 LIG MAVS MDA5 NAK NLRC5 NLRX1 NOD27 NOD4 NOD5 NOD9 OTUD5 OTUD7C PCBP2 PIN1 PUBC1 RH116 RIGI RNF125 RNF135 RNF147 RNF216 RNF87 RPS27A SFT T6BP TAX1BP1 TBK1 TNFAIP3 TRAF3 TRAFAMN TRIAD3 TRIM25 TRIM4 UBA52 UBA7 UBA80 UBB UBC UBC4 UBC5A UBC5B UBC5C UBCE7IP1 UBCEP1 UBCEP2 UBCH4 UBCH5 UBCH5A UBCH5B UBCH5C UBCH8 UBE1L UBE2 UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L6 UCRP VISA ZIN ZNF147	Homo sapiens (human)
Defective pyroptosis	DNA (cytosine-5)-methyltransferase 1 DNA (cytosine-5)-methyltransferase 3A DNA (cytosine-5)-methyltransferase 3B DNA polymerase alpha catalytic subunit DNA polymerase alpha subunit B DNA primase large subunit DNA primase small subunit Gasdermin-E Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 Polycomb protein EED Polycomb protein SUZ12	O60443 O60814 O75530 P04908 P06899 P09884 P0C5Y9 P16104 P20671 P23527 P26358 P33778 P49642 P49643 P57053 P58876 P62805 P62807 P68431 P84243 Q09028 Q14181 Q15022 Q15910 Q16576 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q93077 Q93079 Q96A08 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9UBC3 Q9Y6K1	AIM CHET9 CXXC9 DFNA5 DNMT DNMT1 DNMT3A DNMT3B EED EZH2 GSDME H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 ICERE1 JJAZ1 KIAA0160 KMT6 POLA POLA1 POLA2 PRIM1 PRIM2 PRIM2A RBAP46 RBAP48 RBBP4 RBBP7 SUZ12 TSH2B	Homo sapiens (human)
Regulation of IGF Activity by IGFBP	72 kDa type IV collagenase Albumin Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Alpha-1-antitrypsin Alpha-2-HS-glycoprotein Alpha-fetoprotein Ameloblastin Amelogenin, X isoform Amelotin Amyloid beta precursor like protein 2 Amyloid-beta precursor protein Anoctamin-8 Antithrombin-III Apolipoprotein A-I Apolipoprotein A-II Apolipoprotein A-V Apolipoprotein B-100 Apolipoprotein E Apolipoprotein L1 BPI fold-containing family B member 2 Bone morphogenetic protein 15 Bone morphogenetic protein 4 CCN family member 1 Cadherin-2 Calumenin Cathepsin G Ceruloplasmin Chordin-like protein 1 Coagulation factor V Complement C3 Complement C4-A Cystatin-C Cytoskeleton-associated protein 4 Dentin matrix acidic phosphoprotein 1 Disintegrin and metalloproteinase domain-containing protein 10 DnaJ homolog subfamily C member 3 Enamelin Endoplasmin Extracellular serine/threonine protein kinase FAM20C Fibrillin-1 Fibrinogen alpha chain Fibrinogen gamma chain Fibroblast growth factor 23 Fibronectin Follistatin-related protein 1 Follistatin-related protein 3 Galectin-1 Glucosidase 2 subunit beta Glypican-3 Golgi membrane protein 1 Granzyme H Growth arrest-specific protein 6 Heparin cofactor 2 Insulin-like growth factor I Insulin-like growth factor II Insulin-like growth factor-binding protein 1 Insulin-like growth factor-binding protein 2 Insulin-like growth factor-binding protein 3 Insulin-like growth factor-binding protein 4 Insulin-like growth factor-binding protein 5 Insulin-like growth factor-binding protein 6 Insulin-like growth factor-binding protein 7 Insulin-like growth factor-binding protein complex acid labile subunit Inter-alpha-trypsin inhibitor heavy chain H2 Interleukin-6 Interstitial collagenase Kallikrein-13 Kallikrein-1 Kallikrein-2 Kinectin Kininogen-1 Lactadherin Laminin subunit beta-1 Laminin subunit beta-2 Laminin subunit gamma-1 Latent-transforming growth factor beta-binding protein 1 Macrophage colony-stimulating factor 1 Matrilin-3 Matrix extracellular phosphoglycoprotein Matrix remodeling-associated protein 8 Melanotransferrin Membrane-bound transcription factor site-1 protease Menin Mesothelin Metalloproteinase inhibitor 1 Neurosecretory protein VGF Nucleobindin-1 Osteopontin Palmitoleoyl-protein carboxylesterase NOTUM Pappalysin-1 Pappalysin-2 Patatin-like phospholipase domain-containing protein 2 Plasma alpha-L-fucosidase Plasminogen Proenkephalin-A Proprotein convertase subtilisin/kexin type 9 Prostate-specific antigen Protein Z-dependent protease inhibitor Protein disulfide-isomerase A6 Protein disulfide-isomerase Protein eva-1 homolog A Protein shisa-5 Prothrombin Pseudokinase FAM20A Reticulocalbin-1 SPARC-like protein 1 Sarcoplasmic reticulum histidine-rich calcium-binding protein Secreted phosphoprotein 24 Secretogranin-1 Secretogranin-2 Secretogranin-3 Serine protease 23 Serotransferrin Stanniocalcin-2 Sulfhydryl oxidase 1 Syndecan-2 Tenascin Trans-Golgi network integral membrane protein 2 Transmembrane protein 132A Transport and Golgi organization protein 1 homolog Versican core protein Vitamin K-dependent protein C Wolframin von Willebrand factor A domain-containing protein 1	O00255 O00391 O00622 O14672 O14791 O15232 O15240 O43493 O43852 O76024 O76061 O95084 O95633 O95972 P00450 P00734 P00747 P01008 P01009 P01024 P01033 P01034 P01042 P01210 P01344 P02647 P02649 P02652 P02671 P02679 P02751 P02765 P02768 P02771 P02787 P03956 P04070 P04114 P05019 P05060 P05067 P05231 P05546 P06870 P07237 P07288 P07942 P08253 P08311 P08582 P08833 P09382 P09603 P0C0L4 P10451 P11047 P12259 P12644 P13521 P13611 P14314 P14625 P17936 P18065 P19022 P19823 P20151 P20718 P22692 P23327 P24592 P24593 P24821 P34741 P35555 P35858 P51654 P55268 Q02818 Q06481 Q07065 Q08431 Q12841 Q13103 Q13217 Q13219 Q13316 Q13421 Q14393 Q14515 Q14703 Q14766 Q15084 Q15293 Q16270 Q24JP5 Q5JRA6 Q6P988 Q6PCB0 Q6Q788 Q6UX39 Q86UP2 Q8IXL6 Q8N114 Q8N4F0 Q8NBJ4 Q8NBP7 Q8WXD2 Q96AD5 Q96MK3 Q99217 Q9BRK3 Q9BTY2 Q9BU40 Q9BXP8 Q9GZV9 Q9H8M9 Q9HCE9 Q9NP70 Q9NQ76 Q9NRM1 Q9UK55 Q9UKR3 Q9UM21	A4 AAT AD1 ADAM10 AFP AHSG ALB ALS AMBN AMELX AMG AMGX AMTN ANO8 APLP2 APOA1 APOA2 APOA5 APOB APOE APOL APOL1 APP APPL2 APS AT3 ATGL AXLLG BDK BMP15 BMP2B BMP4 BNSP BP2 BPIFB2 BPIL1 C20orf184 C3 C4A C9orf155 CALU CCN1 CDH2 CDHN CG1 CGL2 CHGB CHGC CHRDL1 CKAP4 CLG CLG4A CLGI CO4 CP CPAMD1 CPAMD2 CSF1 CSPG2 CST3 CTSG CTSGL2 CYR61 DMP1 DMP4 DNAJC3 DVR4 ENAM ERBA2L ERP5 EVA1A F2 F5 FAM176A FAM20A FAM20C FBN FBN1 FETUA FGA FGF23 FGG FLRG FN FN1 FRP FSTL1 FSTL3 FUCA2 G19P1 GAS6 GDF9B GIG1 GOLM1 GOLPH2 GPC3 GRP94 GZMH HCF2 HCP HPAFP HRC HSP90B1 HSPA5BP1 HSPC4 HSPG1 HXB HYPF IBP1 IBP2 IBP3 IBP4 IBP5 IBP6 IFNB2 IGF1 IGF2 IGFALS IGFBP1 IGFBP10 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGHEP2 IL6 ITIH2 KIAA0004 KIAA0091 KIAA0268 KIAA1583 KIAA1623 KLK1 KLK13 KLK2 KLK3 KLKL4 KNG KNG1 KTN1 KUZ LAMB1 LAMB2 LAMC1 LAMS LGALS1 LPLUNC2 LTBP1 MAC25 MADM MAP97 MATN3 MBTPS1 MELTF MEN1 MEPE MFGE8 MFI2 MGAT4A MIA3 MMP1 MMP2 MPF MSLN MXRA8 NARC1 NCAD NOTUM NRLN1 NUC NUCB1 OCI5 OPN P4HB P5 P58IPK PAPPA PAPPA2 PCSK9 PDI PDIA1 PDIA6 PENK PI PLAC3 PLG PNPLA2 PO4DB PRKCSH PRKRI PROC PRSS23 PSF QSCN6 QSOX1 RAP3 RCN RCN1 S1P SCG1 SCG2 SCG3 SCOTIN SDC2 SERPINA1 SERPINA10 SERPINC1 SERPIND1 SHISA5 SKI1 SPARCL1 SPP1 SPP2 SPP24 STC2 TANGO TF TGN46 TGN51 TGOLN2 TIMP TIMP1 TMEM132A TMEM166 TMEM16H TNC TRA1 TXNDC7 VCAN VGF VWA1 WFS1 ZPI ZSIG13	Homo sapiens (human)
Regulation of expression of SLITs and ROBOs	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Collagen alpha-5(IV) chain Cullin-2 Dystroglycan 1 E3 ubiquitin-protein ligase RBX1 Elongin-B Elongin-C Eukaryotic initiation factor 4A-III Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Eukaryotic peptide chain release factor GTP-binding subunit ERF3B Eukaryotic peptide chain release factor subunit 1 Eukaryotic translation initiation factor 4 gamma 1 Homeobox protein Hox-A2 Insulin gene enhancer protein ISL-1 LIM domain-binding protein 1 LIM/homeobox protein Lhx2 LIM/homeobox protein Lhx3 LIM/homeobox protein Lhx4 LIM/homeobox protein Lhx9 Large ribosomal subunit protein P1 Large ribosomal subunit protein P2 Large ribosomal subunit protein eL13 Large ribosomal subunit protein eL14 Large ribosomal subunit protein eL15 Large ribosomal subunit protein eL18 Large ribosomal subunit protein eL19 Large ribosomal subunit protein eL20 Large ribosomal subunit protein eL21 Large ribosomal subunit protein eL22 Large ribosomal subunit protein eL24 Large ribosomal subunit protein eL27 Large ribosomal subunit protein eL28 Large ribosomal subunit protein eL29 Large ribosomal subunit protein eL30 Large ribosomal subunit protein eL31 Large ribosomal subunit protein eL32 Large ribosomal subunit protein eL33 Large ribosomal subunit protein eL34 Large ribosomal subunit protein eL36 Large ribosomal subunit protein eL37 Large ribosomal subunit protein eL38 Large ribosomal subunit protein eL39 Large ribosomal subunit protein eL42 Large ribosomal subunit protein eL43 Large ribosomal subunit protein eL6 Large ribosomal subunit protein eL8 Large ribosomal subunit protein uL10 Large ribosomal subunit protein uL11 Large ribosomal subunit protein uL13 Large ribosomal subunit protein uL14 Large ribosomal subunit protein uL15 Large ribosomal subunit protein uL16 Large ribosomal subunit protein uL18 Large ribosomal subunit protein uL1 Large ribosomal subunit protein uL22 Large ribosomal subunit protein uL23 Large ribosomal subunit protein uL24 Large ribosomal subunit protein uL29 Large ribosomal subunit protein uL2 Large ribosomal subunit protein uL30 Large ribosomal subunit protein uL3 Large ribosomal subunit protein uL4 Large ribosomal subunit protein uL5 Large ribosomal subunit protein uL6 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Polyadenylate-binding protein 1 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Protein CASC3 Protein mago nashi homolog 2 Protein mago nashi homolog RNA-binding protein 8A RNA-binding protein Musashi homolog 1 RNA-binding protein with serine-rich domain 1 Regulator of nonsense transcripts 2 Regulator of nonsense transcripts 3A Regulator of nonsense transcripts 3B Ribosomal protein eL22-like Ribosomal protein eL39-like 2 Ribosomal protein eL42-like Ribosomal protein eS27-like Ribosomal protein uL16-like Ribosomal protein uL24-like Ribosomal protein uL3-like Roundabout homolog 1 Roundabout homolog 2 Slit homolog 1 protein Slit homolog 2 protein Small ribosomal subunit protein eS10 Small ribosomal subunit protein eS12 Small ribosomal subunit protein eS17 Small ribosomal subunit protein eS19 Small ribosomal subunit protein eS1 Small ribosomal subunit protein eS21 Small ribosomal subunit protein eS24 Small ribosomal subunit protein eS25 Small ribosomal subunit protein eS26 Small ribosomal subunit protein eS27 Small ribosomal subunit protein eS28 Small ribosomal subunit protein eS32 Small ribosomal subunit protein eS4, X isoform Small ribosomal subunit protein eS4, Y isoform 1 Small ribosomal subunit protein eS4, Y isoform 2 Small ribosomal subunit protein eS6 Small ribosomal subunit protein eS7 Small ribosomal subunit protein eS8 Small ribosomal subunit protein uS10 Small ribosomal subunit protein uS11 Small ribosomal subunit protein uS12 Small ribosomal subunit protein uS13 Small ribosomal subunit protein uS14 Small ribosomal subunit protein uS15 Small ribosomal subunit protein uS17 Small ribosomal subunit protein uS19 Small ribosomal subunit protein uS2 Small ribosomal subunit protein uS3 Small ribosomal subunit protein uS4 Small ribosomal subunit protein uS5 Small ribosomal subunit protein uS7 Small ribosomal subunit protein uS8 Small ribosomal subunit protein uS9 Ubiquitin carboxyl-terminal hydrolase 33 Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Zinc finger SWIM domain-containing protein 8	A5LHX3 A7E2V4 O00231 O00232 O00233 O00487 O14818 O15234 O43242 O43347 O43364 O75093 O75832 O94813 P05386 P05387 P05388 P08708 P08865 P0CG47 P0CG48 P11940 P15170 P15880 P17980 P18077 P18124 P18621 P20618 P22090 P23396 P25398 P25786 P25787 P25788 P25789 P26373 P27635 P28062 P28065 P28066 P28070 P28072 P28074 P29400 P30050 P32969 P35268 P35998 P36578 P38919 P39019 P39023 P40306 P40429 P42677 P42766 P43686 P46776 P46777 P46778 P46779 P46781 P46782 P46783 P47914 P48556 P49207 P49720 P49721 P50458 P50914 P51665 P52298 P55036 P60866 P60896 P60900 P61247 P61254 P61289 P61313 P61326 P61353 P61371 P61513 P61927 P62081 P62191 P62195 P62241 P62244 P62249 P62263 P62266 P62269 P62273 P62277 P62280 P62333 P62424 P62495 P62701 P62750 P62753 P62829 P62841 P62847 P62851 P62854 P62857 P62861 P62877 P62888 P62891 P62899 P62906 P62910 P62913 P62917 P62945 P62979 P62987 P63173 P63220 P83731 P83881 P84098 Q02543 Q02878 Q04637 Q06323 Q07020 Q09161 Q13200 Q13617 Q14118 Q14997 Q15008 Q15287 Q15369 Q15370 Q16401 Q6P5R6 Q71UM5 Q86U70 Q8IYD1 Q8TAA3 Q8TD47 Q8TEY7 Q92530 Q92901 Q969G2 Q969Q0 Q96A72 Q96EH5 Q96L21 Q99436 Q99460 Q9BZI7 Q9H1J1 Q9HAU5 Q9HCK4 Q9NQ69 Q9UBR4 Q9UL46 Q9UNM6 Q9UNX3 Q9Y3U8 Q9Y5S9 Q9Y6N7	BBC1 C7orf76 CASC3 CBP20 CBP80 CCG2 CLIM2 COL4A5 CUL2 D11S2243E D6S218E DAG1 DDX48 DSS1 DUTT1 DXS648E EC45 EIF4A3 EIF4F EIF4G EIF4G1 EIF4GI ELOB ELOC ERF1 ERF3A ERF3B ETF1 FAU FTE1 GSPT1 GSPT2 HC2 HC3 HC8 HC9 HOX1K HOXA2 HSPC IFI5111 ISL1 KIAA0072 KIAA0077 KIAA0107 KIAA0111 KIAA0813 KIAA0913 KIAA1097 KIAA1408 KIAA1568 LAMBR LAMR1 LDB1 LDC2 LH2 LHX2 LHX3 LHX4 LHX9 LMP10 LMP2 LMP7 LMPX LMPY MAGOH MAGOH2 MAGOHA MAGOHB MB1 MCB1 MECL1 MEGF4 MFTL MIP224 MLN51 MOV34L MPS1 MSI1 MSS1 NCBP NCBP1 NCBP2 NEDD6 NU PAB1 PABP PABP1 PABPC1 PABPC2 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 QM RBM8 RBM8A RBX1 RENT2 RENT3A RENT3B RF1 RIG RING10 RING12 RNF75 RNPS1 ROBO1 ROBO2 ROC1 RPL1 RPL10 RPL10A RPL10L RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL22L1 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL26P1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL36AL RPL37 RPL37A RPL38 RPL39 RPL39L RPL39L1 RPL3L RPL4 RPL41 RPL44 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPL9P7 RPL9P8 RPL9P9 RPLP0 RPLP1 RPLP2 RPP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS17L RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS27L RPS28 RPS29 RPS3 RPS3A RPS4 RPS4X RPS4Y RPS4Y1 RPS4Y2 RPS4Y2P RPS5 RPS6 RPS7 RPS8 RPS9 RPSA RRP1 SCAR SEM1 SHFDG1 SHFM1 SLIL1 SLIL3 SLIT1 SLIT2 SUG1 SUG2 SUP45L1 SURF-3 SURF3 TBP1 TBP7 TCEB1 TCEB2 TRAP2 TXREB1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UPF2 UPF3 UPF3A UPF3B UPF3X USP33 VDU1 X Y Y2 Z ZSWIM8	Homo sapiens (human)
HIV Transcription Initiation	CDK-activating kinase assembly factor MAT1 Cyclin-H Cyclin-dependent kinase 7 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIE subunit 1 General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 TATA-binding protein-associated factor 2N TATA-box-binding protein Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA subunit 2 Transcription initiation factor IIB Transcription initiation factor IIE subunit beta Transcription initiation factor TFIID subunit 1-like Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 11 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 3 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 4B Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 7-like Transcription initiation factor TFIID subunit 7 Transcription initiation factor TFIID subunit 9 Transcription initiation factor TFIID subunit 9B	O00268 O15514 P13984 P18074 P19387 P19388 P19447 P20226 P21675 P24928 P29083 P29084 P30876 P32780 P35269 P36954 P49848 P50613 P51946 P51948 P52434 P52435 P52655 P52657 P53803 P61218 P62487 P62875 Q00403 Q12962 Q13888 Q13889 Q15542 Q15543 Q15544 Q15545 Q16514 Q16594 Q5H9L4 Q5VWG9 Q6P1X5 Q6ZYL4 Q8IZX4 Q92750 Q92759 Q92804 Q9HBM6	BA2R BTF2 BTF2P44 C6orf175 CAK CAK1 CAP35 CCG1 CCGS CCNH CDK7 CDKN7 CIF150 ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2D1 GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 MAT1 MNAT1 MO15 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RAP30 RAP74 RBP56 RNF66 RPB7 STK1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1L TAF2 TAF2A TAF2B TAF2C TAF2C1 TAF2C2 TAF2D TAF2E TAF2F TAF2G TAF2H TAF2I TAF2J TAF2K TAF2N TAF2Q TAF3 TAF4 TAF4A TAF4B TAF5 TAF6 TAF7 TAF7L TAF9 TAF9B TAF9L TAFII105 TAFII130 TAFII135 TAFII18 TAFII20 TAFII30 TAFII31 TAFII55 TAFII70 TBP TF2A1 TF2A2 TF2B TF2D TF2E1 TF2E2 TFIIB TFIID TTDA XPB XPBC XPD XPDC	Homo sapiens (human)
Defective C1GALT1C1 causes TNPS	C1GALT1-specific chaperone 1 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Mucin-12 Mucin-13 Mucin-15 Mucin-16 Mucin-17 Mucin-19 Mucin-1 Mucin-20 Mucin-21 Mucin-2 Mucin-3A Mucin-3B Mucin-4 Mucin-5AC Mucin-5B Mucin-6 Mucin-7 Mucin-like protein 1	P15941 P98088 Q02505 Q02817 Q5SSG8 Q685J3 Q6W4X9 Q7Z5P9 Q8N307 Q8N387 Q8TAX7 Q8WXI7 Q96DR8 Q96EU7 Q99102 Q9H195 Q9H3R2 Q9HC84 Q9NS00 Q9UKN1	C1GALT1 C1GALT1C1 C6orf205 CA125 COSMC DRCC1 KIAA1359 MG2 MUC1 MUC11 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC20 MUC21 MUC3 MUC3A MUC3B MUC4 MUC5 MUC5AC MUC5B MUC6 MUC7 MUCL1 PUM RECC SBEM SMUC	Homo sapiens (human)
Iron uptake and transport	Broad substrate specificity ATP-binding cassette transporter ABCG2 Ceruloplasmin Cullin-1 Cullin-associated NEDD8-dissociated protein 1 Cytoplasmic aconitate hydratase F-box/LRR-repeat protein 5 Ferritin heavy chain Ferritin light chain Ferritin, mitochondrial Glutaredoxin-3 Heme oxygenase 1 Heme oxygenase 2 Hephaestin Iron-responsive element-binding protein 2 NEDD8 Natural resistance-associated macrophage protein 2 Neutrophil gelatinase-associated lipocalin Plasma membrane ascorbate-dependent reductase CYBRD1 Polyubiquitin-B Polyubiquitin-C Proton-coupled folate transporter S-phase kinase-associated protein 1 Serotransferrin Solute carrier family 22 member 17 Solute carrier family 40 member 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O76003 P00450 P02787 P02792 P02794 P09601 P0CG47 P0CG48 P21399 P30519 P48200 P49281 P62979 P62987 P63208 P80188 Q13616 Q15843 Q53TN4 Q86VP6 Q8N4E7 Q8WUG5 Q96NT5 Q9BQS7 Q9NP59 Q9UKA1 Q9UNQ0	ABCG2 ABCP ACO1 BCRP BCRP1 BOCT BOIT CAND1 CP CUL1 CYBRD1 DCT1 DCYTB DMT1 EMC19 FBL4 FBL5 FBXL5 FLR1 FPN FPN1 FRRS3 FTH FTH1 FTHL6 FTL FTMT G21 GLRX3 HCP1 HEPH HMOX1 HMOX2 HNL HO HO1 HO2 IREB1 IREB2 IREG1 KIAA0698 KIAA0829 LCN2 MXR NEDD8 NGAL NRAMP2 OCP2 PCFT PICOT RPS27A SKP1 SKP1A SLC11A2 SLC11A3 SLC22A17 SLC40A1 SLC46A1 TCEB1L TF TIP120 TIP120A TXNL2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Calcineurin-binding protein cabin-1 Cellular tumor antigen p53 E1A-binding protein p400 High mobility group protein HMG-I/HMG-Y High mobility group protein HMGI-C Histone H1.0 Histone H1.1 Histone H1.2 Histone H1.3 Histone H1.4 Histone H1.5 Histone chaperone ASF1A Lamin-B1 Protein HIRA Retinoblastoma-associated protein Ubinuclein-1	P04637 P06400 P07305 P10412 P16401 P16402 P16403 P17096 P20700 P52926 P54198 Q02539 Q96L91 Q9NPG3 Q9Y294 Q9Y6J0	ASF1A CABIN1 CAGH32 DGCR1 EP400 H1-0 H1-1 H1-2 H1-3 H1-4 H1-5 H1F0 H1F1 H1F2 H1F3 H1F4 H1F5 H1FV HIR HIRA HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HMGA1 HMGA2 HMGIC HMGIY KIAA0330 KIAA1498 KIAA1818 LMN2 LMNB LMNB1 P53 RB1 TNRC12 TP53 TUPLE1 UBN1	Homo sapiens (human)
Choline catabolism	Alpha-aminoadipic semialdehyde dehydrogenase Betaine--homocysteine S-methyltransferase 1 Choline dehydrogenase, mitochondrial Choline transporter-like protein 1 Dimethylglycine dehydrogenase, mitochondrial Sarcosine dehydrogenase, mitochondrial	P49419 Q8NE62 Q8WWI5 Q93088 Q9UI17 Q9UL12	ALDH7A1 ATQ1 BHMT CD92 CDW92 CHDH CTL1 DMGDH DMGDHL1 SARDH SLC44A1	Homo sapiens (human)
Specification of primordial germ cells	Bone morphogenetic protein 4 C-X-C chemokine receptor type 4 Eomesodermin homolog Homeobox protein NANOG Methylcytosine dioxygenase TET2 Nanos homolog 3 POU domain, class 5, transcription factor 1 PR domain zinc finger protein 1 Podoplanin Protein CBFA2T2 Transcription factor AP-2 gamma Transcription factor SOX-17	O43439 O75626 O95936 P12644 P60323 P61073 Q01860 Q6N021 Q86YL7 Q92754 Q9H6I2 Q9H9S0	BLIMP1 BMP2B BMP4 CBFA2T2 CXCR4 DVR4 EHT EOMES GP36 KIAA1546 MTGR1 NANOG NANOS3 NOS3 OCT3 OCT4 OTF3 PDPN POU5F1 PRDM1 SOX17 TBR2 TET2 TFAP2C	Homo sapiens (human)
MyD88 dependent cascade initiated on endosome	Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-associated kinase-like 2 Myeloid differentiation primary response protein MyD88 TNF receptor-associated factor 6 Toll-like receptor 7 Toll-like receptor 9	O43187 P51617 Q99836 Q9NR96 Q9NWZ3 Q9NYK1 Q9Y4K3	IRAK IRAK1 IRAK2 IRAK4 MYD88 RNF85 TLR7 TLR9 TRAF6	Homo sapiens (human)

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