GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1101 - 1125** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▲	GlyTouCan ID
Signaling by GSK3beta mutants	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Catenin beta-1 Glycogen synthase kinase-3 beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 P25054 P30153 P30154 P35222 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6	AMER1 APC AXIN AXIN1 CSNK1A1 CTNNB CTNNB1 DP2.5 FAM123B GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
Signaling by Retinoic Acid	Carnitine O-palmitoyltransferase 1, liver isoform Carnitine O-palmitoyltransferase 1, muscle isoform Cellular retinoic acid-binding protein 2 Dihydrolipoyl dehydrogenase, mitochondrial Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Fatty acid-binding protein 5 Peroxisome proliferator-activated receptor delta Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase protein X component, mitochondrial Retinoic acid receptor RXR-alpha Retinoic acid receptor RXR-beta Retinoic acid receptor RXR-gamma Retinoic acid receptor alpha Retinoic acid receptor beta Retinoic acid receptor gamma [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	O00330 P08559 P09622 P10276 P10515 P10826 P11177 P13631 P19793 P28702 P29373 P29803 P48443 P50416 Q01469 Q03181 Q15118 Q15119 Q15120 Q16654 Q92523	CPT1 CPT1A CPT1B CRABP2 DLAT DLD DLTA FABP5 GCSL HAP KIAA1670 LAD NR1B1 NR1B2 NR1B3 NR1C2 NR2B1 NR2B2 NR2B3 PDHA1 PDHA2 PDHAL PDHB PDHK1 PDHK2 PDHK3 PDHK4 PDHX PDK1 PDK2 PDK3 PDK4 PDX1 PHE1A PHE1B PHE3 PPARB PPARD RARA RARB RARG RXRA RXRB RXRG	Homo sapiens (human)
Translocation of ZAP-70 to Immunological synapse	HLA class II histocompatibility antigen, DP alpha 1 chain HLA class II histocompatibility antigen, DP beta 1 chain HLA class II histocompatibility antigen, DQ alpha 1 chain HLA class II histocompatibility antigen, DQ alpha 2 chain HLA class II histocompatibility antigen, DQ beta 1 chain HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DR alpha chain HLA class II histocompatibility antigen, DR beta 3 chain HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1 beta chain T cell receptor alpha chain constant T cell receptor alpha variable 19 T cell receptor alpha variable 29/delta variable 5 T cell receptor alpha variable 8-4 T cell receptor beta constant 1 T cell receptor beta variable 12-3 T cell receptor beta variable 7-9 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Lck Tyrosine-protein kinase ZAP-70 Tyrosine-protein phosphatase non-receptor type 22	A0A0A6YYK7 P01730 P01733 P01737 P01848 P01850 P01903 P01906 P01909 P01911 P01920 P04234 P04435 P04437 P04440 P05538 P06239 P07766 P09693 P13762 P20036 P43403 P79483 Q30154 Q9Y2R2	CD3D CD3E CD3G CD4 HLA-DP1A HLA-DP1B HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRA1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-DXA HLA-DXB HLASB LCK PTPN22 PTPN8 SRK T3D T3E T3G TCRA TCRBV12S3 TCRBV8S1 TRAC TRAV19 TRAV29DV5 TRAV8-4 TRBC1 TRBV12-3 TRBV7-9 ZAP70	Homo sapiens (human)
Defective B4GALT7 causes EDS, progeroid type	Agrin Basement membrane-specific heparan sulfate proteoglycan core protein Beta-1,4-galactosyltransferase 7 Biglycan Brevican core protein Chondroitin sulfate proteoglycan 4 Chondroitin sulfate proteoglycan 5 Decorin Glypican-1 Glypican-2 Glypican-3 Glypican-4 Glypican-5 Glypican-6 Neurocan core protein Syndecan-1 Syndecan-2 Syndecan-3 Syndecan-4 Versican core protein	O00468 O14594 O75056 O75487 O95196 P07585 P13611 P18827 P21810 P31431 P34741 P35052 P51654 P78333 P98160 Q6UVK1 Q8N158 Q96GW7 Q9UBV7 Q9Y625	AGRIN AGRN B4GALT7 BCAN BEHAB BGN CALEB CSPG2 CSPG3 CSPG4 CSPG5 CSPG7 DCN GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HSPG1 HSPG2 KIAA0468 MCSP NCAN NEUR NGC OCI5 SDC SDC1 SDC2 SDC3 SDC4 SLRR1A SLRR1B VCAN XGALT1	Homo sapiens (human)
Regulation by c-FLIP	Caspase-8 FAS-associated death domain protein Receptor-interacting serine/threonine-protein kinase 1 TNF receptor-associated factor 2 Tumor necrosis factor ligand superfamily member 10 Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor receptor superfamily member 10A Tumor necrosis factor receptor superfamily member 10B Tumor necrosis factor receptor superfamily member 6 Tumor necrosis factor receptor type 1-associated DEATH domain protein	O00220 O14763 P25445 P48023 P50591 Q12933 Q13158 Q13546 Q14790 Q15628	APO2 APO2L APT1 APT1LG1 CASP8 CD95L DR4 DR5 FADD FAS FAS1 FASL FASLG KILLER MCH5 MORT1 RIP RIP1 RIPK1 TNFRSF10A TNFRSF10B TNFRSF6 TNFSF10 TNFSF6 TRADD TRAF2 TRAIL TRAILR1 TRAILR2 TRAP3 TRICK2 ZTNFR9	Homo sapiens (human)
Processing of DNA double-strand break ends	ATR-interacting protein BRCA1-A complex subunit Abraxas 1 BRCA1-A complex subunit RAP80 BRCA1-associated RING domain protein 1 BRISC and BRCA1-A complex member 1 BRISC and BRCA1-A complex member 2 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Checkpoint protein HUS1 Claspin Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 2 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 2-binding protein 1 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 E3 SUMO-protein ligase PIAS4 E3 ubiquitin-protein ligase HERC2 E3 ubiquitin-protein ligase RNF168 E3 ubiquitin-protein ligase RNF4 E3 ubiquitin-protein ligase RNF8 Exonuclease 1 Fanconi anemia group J protein Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1t Histone H4 Histone acetyltransferase KAT5 Histone-lysine N-methyltransferase NSD2 Lys-63-specific deubiquitinase BRCC36 Mediator of DNA damage checkpoint protein 1 NAD-dependent protein deacylase sirtuin-6 Nibrin Polyubiquitin-B Polyubiquitin-C Protein timeless homolog RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit SUMO-conjugating enzyme UBC9 Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1 Serine/threonine-protein phosphatase 4 catalytic subunit Serine/threonine-protein phosphatase 4 regulatory subunit 2 Small ubiquitin-related modifier 2 TIMELESS-interacting protein TP53-binding protein 1 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14757 O60671 O60814 O60921 O60934 O75943 O76064 O95714 O96028 P06899 P0CG47 P0CG48 P15927 P16104 P20248 P23527 P24941 P27694 P33778 P35244 P35249 P35250 P38398 P40937 P40938 P46736 P49959 P51530 P54132 P57053 P58876 P60510 P61088 P61956 P62805 P62807 P62979 P62987 P63279 P78317 P78396 Q12888 Q13315 Q13472 Q13535 Q14191 Q14676 Q15819 Q16695 Q16778 Q6UWZ7 Q6WBX8 Q8IYW5 Q8N257 Q8N2W9 Q8N6T7 Q8WXE1 Q92547 Q92878 Q92993 Q93079 Q96A08 Q96E14 Q96RL1 Q99638 Q99708 Q99728 Q99877 Q99879 Q99880 Q9BSD3 Q9BVW5 Q9BX63 Q9H9A7 Q9HAW4 Q9NWV8 Q9NXR7 Q9NY27 Q9UNS1 Q9UQ84	ABRA1 ABRAXAS1 AGS1 ATM ATR ATRIP BABAM1 BABAM2 BACH1 BARD1 BLM BLU BRCA1 BRCC3 BRCC36 BRCC45 BRE BRIP1 C12orf32 C16orf75 C19orf62 C6.1A C9orf76 CCDC98 CCN1 CCNA CCNA1 CCNA2 CDK2 CDKN2 CHEK1 CHK1 CLSPN CTIP CXorf53 DNA2 DNA2L EXO1 EXOI FAM175A FANCJ FRP1 H2AFX H2AX H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-4 H3FT H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HERC2 HEX1 HIRIP1 HIRIP2 HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2BE HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HNGS1 HTATIP HUS1 KAT5 KIAA0083 KIAA0170 KIAA0259 KIAA0646 KIAA1090 MDC1 MERIT40 MMS2 MMSET MRE11 MRE11A NBA1 NBN NBS NBS1 NFBD1 NSD2 P95 PIAS4 PIASG PPP4 PPP4C PPP4R2 PPX R24L RAD1 RAD17 RAD50 RAD9A RAD9B RAP80 RBBP8 REC1 RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RHINO RHNO1 RMI1 RMI2 RNF168 RNF4 RNF53 RNF8 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A RXRIP110 SIR2L6 SIRT6 SMT3B SMT3H2 SNURF SUMO2 TIM TIM1 TIMELESS TIMELESS1 TIP60 TIPIN TOP3 TOP3A TOPBP1 TP53BP1 TRX5 TSH2B UBA52 UBA80 UBB UBC UBC9 UBCE9 UBCEP1 UBCEP2 UBE2I UBE2N UBE2V2 UEV2 UIMC1 WHSC1 WRN	Homo sapiens (human)
Pyrimidine biosynthesis	Dihydroorotate dehydrogenase (quinone), mitochondrial Multifunctional protein CAD Uridine 5'-monophosphate synthase	P11172 P27708 Q02127	CAD DHODH UMPS	Homo sapiens (human)
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	O60476 P33908 Q9NR34	MAN1A1 MAN1A2 MAN1A3 MAN1B MAN1C MAN1C1	Homo sapiens (human)	G70323CJ
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Amphiregulin Apoptosis regulator Bcl-2 Cyclin-dependent kinase inhibitor 1B ETS domain-containing protein Elk-1 Epidermal growth factor receptor Epigen Exportin-1 Focal adhesion kinase 1 Forkhead box protein O3 G1/S-specific cyclin-D1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein c-Fos Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Serine/threonine-protein kinase Kist Serum response factor	O14944 O14980 O43524 P00533 P01100 P01133 P01135 P10415 P11831 P15514 P19419 P24385 P27361 P28482 P31749 P31751 P35070 P46527 Q05397 Q6UW88 Q8TAS1 Q99075 Q9Y243	AKT1 AKT2 AKT3 AREG AREGB BCL1 BCL2 BTC CCND1 CDKN1B CRM1 DTR DTS EGF EGFR ELK1 EPGN ERBB ERBB1 EREG ERK1 ERK2 FAK FAK1 FKHRL1 FOS FOXO3 FOXO3A G0S7 HBEGF HEGFL HER1 KIP1 KIS KIST MAPK1 MAPK3 PKB PKBG PRAD1 PRKM1 PRKM2 PRKM3 PTK2 RAC SDGF SRF TGFA UHMK1 XPO1 p27	Homo sapiens (human)
MPS IX - Natowicz syndrome	Hyaluronidase-1	Q12794	HYAL1 LUCA1	Homo sapiens (human)	G35674CY
Biosynthesis of DHA-derived SPMs	Polyunsaturated fatty acid lipoxygenase ALOX12 Polyunsaturated fatty acid lipoxygenase ALOX15 Prostaglandin G/H synthase 2	P16050 P18054 P35354	12LO ALOX12 ALOX15 COX2 LOG12 LOG15 PTGS2	Homo sapiens (human)
Signaling by ERBB2 ECD mutants	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Epidermal growth factor receptor Erbin GRB2-associated-binding protein 1 GTPase HRas GTPase NRas Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-epidermal growth factor Receptor tyrosine-protein kinase erbB-2 SHC-transforming protein 1 Son of sevenless homolog 1	P00533 P01111 P01112 P01133 P04626 P07900 P19174 P27986 P29353 P42336 Q07889 Q13480 Q16543 Q96RT1	CDC37 CDC37A EGF EGFR ERBB ERBB1 ERBB2 ERBB2IP ERBIN GAB1 GRB1 HER1 HER2 HRAS HRAS1 HSP90A HSP90AA1 HSPC1 HSPCA KIAA1225 LAP2 MLN19 NEU NGL NRAS PIK3CA PIK3R1 PLC1 PLCG1 SHC SHC1 SHCA SOS1	Homo sapiens (human)
TWIK related potassium channel (TREK)	Potassium channel subfamily K member 10 Potassium channel subfamily K member 2 Potassium channel subfamily K member 4	O95069 P57789 Q9NYG8	KCNK10 KCNK2 KCNK4 TRAAK TREK TREK1 TREK2	Homo sapiens (human)
Acyl chain remodelling of PI	Cytosolic phospholipase A2 delta Cytosolic phospholipase A2 epsilon Cytosolic phospholipase A2 gamma Cytosolic phospholipase A2 zeta Cytosolic phospholipase A2 Group 10 secretory phospholipase A2 Group IID secretory phospholipase A2 Group IIE secretory phospholipase A2 Group IIF secretory phospholipase A2 Group XIIA secretory phospholipase A2 Lysophospholipid acyltransferase 7 Phospholipase A and acyltransferase 3 Phospholipase A2 group V Phospholipase A2, membrane associated Phospholipase A2 Phospholipase B-like 1 Secretory phospholipase A2 receptor	O15496 P04054 P14555 P39877 P47712 P53816 Q13018 Q3MJ16 Q68DD2 Q6P4A8 Q86XP0 Q96N66 Q9BZM1 Q9BZM2 Q9NZK7 Q9UNK4 Q9UP65	BB1 CLEC13C CPLA2 HRASLS3 HREV107 LENG4 MBOAT7 OACT7 PLA2 PLA2A PLA2B PLA2G10 PLA2G12 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G4 PLA2G4A PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2L PLA2R1 PLAAT3 PLBD1 PPLA2 RASF-A SPLASH	Homo sapiens (human)
SARS-CoV-1 activates/modulates innate immune responses	Antiviral innate immune response receptor RIG-I Apoptosis-associated speck-like protein containing a CARD Bone marrow stromal antigen 2 Calcipressin-3 Caspase-1 E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin/ISG15 ligase TRIM25 Envelope small membrane protein Importin subunit alpha-1 Importin subunit beta-1 Inhibitor of nuclear factor kappa-B kinase subunit epsilon Interferon regulatory factor 3 Interferon-induced helicase C domain-containing protein 1 Interleukin-1 receptor-associated kinase-like 2 Membrane protein Mitochondrial antiviral-signaling protein Mitochondrial import receptor subunit TOM70 N-myc-interactor NACHT, LRR and PYD domains-containing protein 3 NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit Nuclear pore complex-interacting protein family member B3 Nucleoprotein ORF3a protein ORF3b protein ORF6 protein ORF7a protein ORF8b protein ORF9b protein Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase B Peptidyl-prolyl cis-trans isomerase FKBP1A Peptidyl-prolyl cis-trans isomerase G Peptidyl-prolyl cis-trans isomerase H Poly(rC)-binding protein 2 Polyubiquitin-B Polyubiquitin-C Pulmonary surfactant-associated protein D Receptor-interacting serine/threonine-protein kinase 3 Replicase polyprotein 1a Replicase polyprotein 1ab Runt-related transcription factor 1 Serine/threonine-protein kinase TBK1 Spike glycoprotein Stimulator of interferon genes protein Suppressor of IKBKE 1 TNF receptor-associated factor 3 TNF receptor-associated factor 6 Toll-like receptor 7 Transcription factor p65 Triokinase/FMN cyclase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O43187 O43447 O94826 O95786 P0C6U8 P0C6X7 P0CG47 P0CG48 P19838 P23284 P25963 P29466 P35247 P52292 P59594 P59595 P59596 P59632 P59633 P59634 P59635 P59636 P59637 P62937 P62942 P62979 P62987 Q01196 Q04206 Q10589 Q13114 Q13287 Q13427 Q14164 Q14258 Q14653 Q14974 Q15366 Q3LXA3 Q7Z434 Q80H93 Q86WV6 Q92617 Q96J02 Q96P20 Q9BRV8 Q9BYX4 Q9NYK1 Q9UHD2 Q9UKA8 Q9ULZ3 Q9Y4K3 Q9Y572	1a 3a 3b 6 7a 8b 9b AML1 ASC BST2 C1orf7 CAP-1 CARD5 CASP1 CBFA2 CIAS1 COLEC7 CRAF1 CYP20 CYPA CYPB CYPH DAK DDX58 DSCR1L2 E EFP ERIS FKBP1 FKBP12 FKBP1A IFIH1 IKBA IKBKE IKKE IKKI IL1BC IL1BCE IPS1 IRAK2 IRF3 ITCH KIAA0151 KIAA0220 KIAA0719 KIAA1271 KPNA2 KPNB1 M MAD3 MAVS MDA5 MITA N NAK NALP3 NFKB1 NFKB3 NFKBI NFKBIA NLRP3 NMI NPIPB3 NPIPL3 NTF97 PCBP2 PPIA PPIB PPIG PPIH PSPD PYCARD PYPAF1 RCAN3 RCH1 RELA RH116 RIGI RIP3 RIPK3 RNF147 RNF85 RPS27A RUNX1 S SFTP4 SFTPD SIKE SIKE1 SRP1 STING STING1 TBK1 TKFC TLR7 TMEM173 TMS1 TOM70 TOMM70 TOMM70A TRAF3 TRAF6 TRAFAMN TRIM25 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VISA ZNF147 rep sM	Homo sapiens (human)
NIK-->noncanonical NF-kB signaling	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-1 F-box/WD repeat-containing protein 11 F-box/WD repeat-containing protein 1A Inhibitor of nuclear factor kappa-B kinase subunit alpha Mitogen-activated protein kinase kinase kinase 14 NEDD8-activating enzyme E1 catalytic subunit NEDD8-conjugating enzyme Ubc12 Nuclear factor NF-kappa-B p100 subunit Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 S-phase kinase-associated protein 1 Transcription factor RelB Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00231 O00232 O00233 O00487 O14818 O15111 O43242 O75832 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61081 P61289 P62191 P62195 P62333 P62979 P62987 P63208 Q00653 Q01201 Q06323 Q13200 Q13616 Q14997 Q15008 Q16401 Q8TAA3 Q8TBC4 Q92530 Q99436 Q99460 Q99558 Q9UKB1 Q9UL46 Q9UNM6 Q9Y297	BTRC BTRCP BTRCP2 C7orf76 CHUK CUL1 DSS1 EMC19 FBW1A FBW1B FBXW11 FBXW1A FBXW1B HC2 HC3 HC8 HC9 HSPC IFI5111 IKKA KIAA0072 KIAA0077 KIAA0107 KIAA0696 LMP10 LMP2 LMP7 LMPX LMPY LYT10 MAP3K14 MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NFKB2 NIK NU OCP2 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RELB RING10 RING12 RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A SUG1 SUG2 TBP1 TBP7 TCEB1L TCF16 TRAP2 UBA3 UBA52 UBA80 UBB UBC UBC12 UBCEP1 UBCEP2 UBE1C UBE2M X Y Y2 Z	Homo sapiens (human)
Primitive streak formation	Bone morphogenetic protein 4 Catenin beta-1 E3 ubiquitin-protein ligase TRIM33 Eomesodermin homolog Forkhead box protein H1 Homeobox protein MIXL1 Homeobox protein NANOG Homeobox protein goosecoid Lymphoid enhancer-binding factor 1 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 POU domain, class 5, transcription factor 1 T-box transcription factor T TATA box-binding protein-like 2 Transcription factor 7 Transcription factor SOX-2	O15178 O75593 O95936 P12644 P35222 P36402 P48431 P56915 P84022 Q01860 Q13485 Q15796 Q6SJ96 Q9H2W2 Q9H9S0 Q9UJU2 Q9UPN9	BMP2B BMP4 CTNNB CTNNB1 DPC4 DVR4 EOMES FAST1 FAST2 FOXH1 GSC KIAA1113 LEF1 MADH2 MADH3 MADH4 MADR2 MIXL MIXL1 NANOG OCT3 OCT4 OTF3 POU5F1 RFG7 SMAD2 SMAD3 SMAD4 SOX2 T TBP2 TBPL2 TBR2 TBXT TCF1 TCF7 TIF1G TRF3 TRIM33	Homo sapiens (human)
Myoclonic epilepsy of Lafora	E3 ubiquitin-protein ligase NHLRC1 Glycogen [starch] synthase, muscle Glycogenin-1 Laforin Polyubiquitin-B Polyubiquitin-C Protein phosphatase 1 regulatory subunit 3C Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O95278 P0CG47 P0CG48 P13807 P46976 P62979 P62987 Q6VVB1 Q9UQK1	EPM2A EPM2B GYG GYG1 GYS GYS1 NHLRC1 PPP1R3C PPP1R5 RPS27A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Recognition of DNA damage by PCNA-containing replication complex	Cullin-4A Cullin-4B DNA damage-binding protein 1 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 Denticleless protein homolog E3 ubiquitin-protein ligase RAD18 E3 ubiquitin-protein ligase RBX1 Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Ubiquitin carboxyl-terminal hydrolase 1 Ubiquitin-conjugating enzyme E2 B Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein WD repeat-containing protein 48	O94782 P0CG47 P0CG48 P12004 P15927 P27694 P28340 P35244 P35249 P35250 P35251 P40937 P40938 P49005 P56282 P62877 P62979 P62987 P63146 Q07864 Q13619 Q13620 Q15054 Q16531 Q8TAF3 Q9HCU8 Q9NR33 Q9NRF9 Q9NS91 Q9NZJ0	CDT2 CDW1 CHRAC17 CUL4A CUL4B DCAF2 DDB1 DPE2 DTL KIAA0039 KIAA0695 KIAA1449 L2DTL PCNA POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 RAD18 RAD6B RAMP RBX1 REPA1 REPA2 REPA3 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RNF73 RNF75 ROC1 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A UAF1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBCH1 UBE2B USP1 WDR48 XAP1	Homo sapiens (human)
Reversal of alkylation damage by DNA dioxygenases	Alpha-ketoglutarate-dependent dioxygenase FTO RNA demethylase ALKBH5	Q6P6C2 Q9C0B1	ABH5 ALKBH5 FTO KIAA1752 OFOXD1	Homo sapiens (human)
Activation of BAD and translocation to mitochondria	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta Apoptosis regulator Bcl-2 BH3-interacting domain death agonist Bcl2-associated agonist of cell death Calcineurin subunit B type 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	P10415 P27348 P31749 P31751 P31946 P31947 P48454 P55957 P61981 P62258 P63098 P63104 Q04917 Q92934 Q9Y243	AKT1 AKT2 AKT3 BAD BBC6 BCL2 BCL2L8 BID CALNA3 CNA2 CNA3 CNB HME1 PKB PKBG PPP3CC PPP3R1 RAC SFN YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	Homo sapiens (human)
Stimuli-sensing channels	Acid-sensing ion channel 1 Acid-sensing ion channel 2 Acid-sensing ion channel 3 Acid-sensing ion channel 4 Acid-sensing ion channel 5 Amiloride-sensitive sodium channel subunit alpha Amiloride-sensitive sodium channel subunit beta Amiloride-sensitive sodium channel subunit delta Amiloride-sensitive sodium channel subunit gamma Anoctamin-10 Anoctamin-1 Anoctamin-2 Anoctamin-3 Anoctamin-4 Anoctamin-5 Anoctamin-6 Anoctamin-7 Anoctamin-8 Anoctamin-9 Aspartyl/asparaginyl beta-hydroxylase Barttin Bestrophin-1 Bestrophin-2a Bestrophin-3 Bestrophin-4 Calcium-activated chloride channel regulator 1 Calcium-activated chloride channel regulator 2 Calcium-activated chloride channel regulator 4 Calcium-activated chloride channel regulator family member 3 Calmodulin-1 Chloride channel protein 1 Chloride channel protein 2 Chloride channel protein ClC-Ka Chloride channel protein ClC-Kb Chloride intracellular channel protein 2 E3 ubiquitin-protein ligase NEDD4-like H(+)/Cl(-) exchange transporter 3 H(+)/Cl(-) exchange transporter 4 H(+)/Cl(-) exchange transporter 5 H(+)/Cl(-) exchange transporter 6 H(+)/Cl(-) exchange transporter 7 NEDD4-like E3 ubiquitin-protein ligase WWP1 Osteopetrosis-associated transmembrane protein 1 Peptidyl-prolyl cis-trans isomerase FKBP1B Polyubiquitin-B Polyubiquitin-C Protein tweety homolog 2 Protein tweety homolog 3 Protein unc-79 homolog Protein unc-80 homolog RAF proto-oncogene serine/threonine-protein kinase Ryanodine receptor 1 Ryanodine receptor 2 Ryanodine receptor 3 Serine/threonine-protein kinase Sgk1 Serine/threonine-protein kinase Sgk2 Serine/threonine-protein kinase Sgk3 Serine/threonine-protein kinase WNK1 Serine/threonine-protein kinase WNK2 Serine/threonine-protein kinase WNK3 Serine/threonine-protein kinase WNK4 Sodium leak channel NALCN Sodium-dependent phosphate transport protein 4 Sodium/hydrogen exchanger 11 Sodium/hydrogen exchanger 9B1 Sodium/hydrogen exchanger 9B2 Solute carrier family 9 member C1 Sorcin Stomatin-like protein 3 Stomatin TSC22 domain family protein 3 Triadin Two pore channel protein 1 Two pore channel protein 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A1A5B4 A8K7I4 O00141 O00476 O15247 O76090 P04049 P0CG47 P0CG48 P0DP23 P21817 P27105 P30626 P35523 P37088 P51168 P51170 P51172 P51788 P51790 P51793 P51795 P51797 P51798 P51800 P51801 P62979 P62987 P68106 P78348 Q12797 Q13061 Q14CN2 Q15413 Q16515 Q32M45 Q4G0N8 Q4KMQ2 Q4ZJI4 Q5TAH2 Q5XXA6 Q6IWH7 Q75V66 Q86UD5 Q86WC4 Q8IZF0 Q8N1M1 Q8N2C7 Q8NFU0 Q8NFU1 Q8NHX9 Q8TAV4 Q8WZ55 Q92736 Q96BR1 Q96FT7 Q96J92 Q96PU5 Q99576 Q9BSA4 Q9BYP7 Q9BYT9 Q9C0H2 Q9H0M0 Q9H4A3 Q9HBY8 Q9HCE9 Q9NQ90 Q9NW15 Q9NY37 Q9P2D8 Q9UHC3 Q9ULQ1 Q9UQC9 Q9Y3S1 Q9Y6N3	ACCN ACCN1 ACCN2 ACCN3 ACCN4 ACCN5 ANO1 ANO10 ANO2 ANO3 ANO4 ANO5 ANO6 ANO7 ANO8 ANO9 ASIC1 ASIC2 ASIC3 ASIC4 ASIC5 ASPH BAH BART BEST1 BEST2 BEST3 BEST4 BNAC1 BNAC2 BND7 BSND C11orf25 C12orf3 C17orf29 C2orf21 CACC1 CACC3 CALM CALM1 CAM CAM1 CISK CLC1 CLCA1 CLCA2 CLCA3 CLCA3P CLCA4 CLCK2 CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 CLCN6 CLCN7 CLCNKA CLCNKB CLIC2 CaCC2 DNACH DOG1 DSIPI EPB72 FKBP12.6 FKBP1B FKBP1L FKBP9 GDD1 GILZ GL HBRR HINAC HSN2 KDP KIAA0046 KIAA0344 KIAA0439 KIAA1169 KIAA1409 KIAA1566 KIAA1623 KIAA1691 KIAA1760 KIAA1843 MDEG NALCN NEDD4L NEDL3 NGEP NHA1 NHA2 NHEDC1 NHEDC2 NPT4 ORAOV2 OSTM1 OTK4 PCANAP5 PIG5 PRKWNK1 PRKWNK2 PRKWNK3 PRKWNK4 RAF RAF1 RPS27A RYDR RYR1 RYR2 RYR3 SCNN1 SCNN1A SCNN1B SCNN1D SCNN1G SDCCAG43 SGK SGK1 SGK2 SGK3 SGKL SLC17A3 SLC9A10 SLC9A11 SLC9B1 SLC9B2 SLC9C1 SLC9C2 SLNAC1 SRI STOM STOML3 TAOS2 TMEM16A TMEM16B TMEM16C TMEM16D TMEM16E TMEM16F TMEM16G TMEM16H TMEM16J TMEM16K TNAC1 TP53I5 TPC1 TPC2 TPCN1 TPCN2 TRDN TSC22D3 TTYH2 TTYH3 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UNC79 UNC80 VGCNL1 VMD2 VMD2L1 VMD2L2 VMD2L3 WNK1 WNK2 WNK3 WNK4 WWP1	Homo sapiens (human)
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	Acid ceramidase V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit E 1 V-type proton ATPase subunit G 1 V-type proton ATPase subunit H V-type proton ATPase subunit d 1 V-type proton ATPase subunit e 1	O15342 O75348 P21281 P21283 P27449 P36543 P38606 P61421 Q13510 Q99437 Q9UI12	ASAH ASAH1 ATP6A1 ATP6B2 ATP6C ATP6D ATP6E ATP6E2 ATP6F ATP6G ATP6G1 ATP6H ATP6J ATP6L ATP6V0B ATP6V0C ATP6V0D1 ATP6V0E ATP6V0E1 ATP6V1A ATP6V1A1 ATP6V1B2 ATP6V1C1 ATP6V1E1 ATP6V1G1 ATP6V1H ATPL VATC VPATPD VPP2 VPP3	Homo sapiens (human)
Assembly of the ORC complex at the origin of replication	Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Importin subunit alpha-5 Importin subunit alpha-7 Importin subunit beta-1 Origin recognition complex subunit 1 Origin recognition complex subunit 2 Origin recognition complex subunit 3 Origin recognition complex subunit 4 Origin recognition complex subunit 5 Origin recognition complex subunit 6	O43913 O43929 O60684 O60814 P04908 P06899 P0C5Y9 P16104 P20671 P23527 P33778 P52294 P57053 P58876 P62805 P62807 P68431 P84243 Q13415 Q13416 Q14974 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q93077 Q93079 Q96A08 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9UBD5 Q9Y5N6	H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 IPOA7 KPNA1 KPNA6 KPNB1 LATHEO NTF97 ORC1 ORC1L ORC2 ORC2L ORC3 ORC3L ORC4 ORC4L ORC5 ORC5L ORC6 ORC6L PARC1 RCH2 TSH2B	Homo sapiens (human)
Activation of BID and translocation to mitochondria	BH3-interacting domain death agonist Caspase-8 Glycylpeptide N-tetradecanoyltransferase 1 Granzyme B	P10144 P30419 P55957 Q14790	BID CASP8 CGL1 CSPB CTLA1 GRB GZMB MCH5 NMT NMT1	Homo sapiens (human)

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