GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **1351 - 1375** of **2090** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol
Purinergic signaling in leishmaniasis infection	5'-nucleotidase Apoptosis-associated speck-like protein containing a CARD C3a anaphylatoxin chemotactic receptor Caspase-1 Cathepsin G Complement C3 Ectonucleoside triphosphate diphosphohydrolase 1 Gasdermin-D Heat shock protein HSP 90-beta Heme oxygenase 1 Interleukin-1 alpha Interleukin-1 beta Interleukin-18 NACHT, LRR and PYD domains-containing protein 3 Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p105 subunit Nucleoside diphosphate phosphatase ENTPD5 P2X purinoceptor 4 P2X purinoceptor 7 Proline-serine-threonine phosphatase-interacting protein 1 Protein SGT1 homolog Pyrin Thioredoxin-interacting protein Thioredoxin Transcription factor p65	O15553 O43586 O75356 P01024 P01583 P01584 P08238 P08311 P09601 P10599 P19838 P21589 P29466 P49961 P57764 Q00653 Q04206 Q14116 Q16581 Q96P20 Q99571 Q99572 Q9H3M7 Q9ULZ3 Q9Y2Z0	ASC AZ3B C1orf7 C3 C3AR1 C3R1 CARD5 CASP1 CD2BP1 CD39 CD39L4 CIAS1 CPAMD1 CTSG DFNA5L ENTPD1 ENTPD5 GSDMD GSDMDC1 HMOX1 HNFAG09 HO HO1 HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IGIF IL18 IL1A IL1B IL1BC IL1BCE IL1F1 IL1F2 IL1F4 LYT10 MEF MEFV NALP3 NFKB1 NFKB2 NFKB3 NLRP3 NT5 NT5E NTE P2RX4 P2RX7 PCPH PSTPIP1 PYCARD PYPAF1 RELA SUGT1 TMS1 TRDX TRIM20 TRX TRX1 TXN TXNIP VDUP1
Pyrimidine biosynthesis	Dihydroorotate dehydrogenase (quinone), mitochondrial Multifunctional protein CAD Uridine 5'-monophosphate synthase	P11172 P27708 Q02127	CAD DHODH UMPS
Pyrimidine catabolism	5'(3')-deoxyribonucleotidase, cytosolic type 5'(3')-deoxyribonucleotidase, mitochondrial 5'-nucleotidase Alanine--glyoxylate aminotransferase 2, mitochondrial Beta-ureidopropionase Cytosolic 5'-nucleotidase 1A Dihydropyrimidinase Dihydropyrimidine dehydrogenase [NADP(+)] Thymidine phosphorylase Uridine phosphorylase 1 Uridine phosphorylase 2	O95045 P19971 P21589 Q12882 Q14117 Q16831 Q8TCD5 Q9BXI3 Q9BYV1 Q9NPB1 Q9UBR1	AGT2 AGXT2 BUP1 DNT1 DNT2 DPYD DPYS ECGF1 NT5 NT5C NT5C1A NT5E NT5M NTE TYMP UMPH2 UP UPB1 UPP1 UPP2
Pyrimidine salvage	Cytidine deaminase Deoxycytidine kinase Pseudouridine-5'-phosphatase Thymidine kinase 2, mitochondrial Thymidine kinase, cytosolic Thymidine phosphorylase Uridine phosphorylase 1 Uridine phosphorylase 2 Uridine-cytidine kinase 1 Uridine-cytidine kinase 2 Uridine-cytidine kinase-like 1	O00142 O95045 P04183 P19971 P27707 P32320 Q08623 Q16831 Q9BZX2 Q9HA47 Q9NWZ5	CDA CDD DCK DXF68S1E ECGF1 FAM16AX GS1 HDHD1 HDHD1A PUDP TK1 TK2 TYMP UCK1 UCK2 UCKL1 UMPK UP UPP1 UPP2 URK1 URKL1
Pyrophosphate hydrolysis	Inorganic pyrophosphatase 2, mitochondrial Inorganic pyrophosphatase Phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Q15181 Q9H008 Q9H2U2	IOPPP LHPP PP PPA1 PPA2
Pyroptosis	Apoptosis regulator BAX Bcl-2 homologous antagonist/killer Caspase-1 Caspase-3 Caspase-4 Caspase-5 Cellular tumor antigen p53 Charged multivesicular body protein 2a Charged multivesicular body protein 2b Charged multivesicular body protein 3 Charged multivesicular body protein 4a Charged multivesicular body protein 4b Charged multivesicular body protein 4c Charged multivesicular body protein 6 Charged multivesicular body protein 7 Cytochrome c Gasdermin-D Gasdermin-E Granzyme B High mobility group protein B1 Interferon regulatory factor 1 Interferon regulatory factor 2 Interleukin-1 alpha Interleukin-1 beta Interleukin-18 Neutrophil elastase Tumor protein 63	O43633 O60443 P01583 P01584 P04637 P08246 P09429 P10144 P10914 P14316 P29466 P42574 P49662 P51878 P57764 P99999 Q07812 Q14116 Q16611 Q8WUX9 Q96CF2 Q96FZ7 Q9BY43 Q9H3D4 Q9H444 Q9UQN3 Q9Y3E7	BAK BAK1 BAX BC2 BCL2L4 BCL2L7 C14orf123 C20orf178 CASP1 CASP3 CASP4 CASP5 CDN1 CGI149 CGL1 CHMP2 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 CPP32 CSPB CTLA1 CYC CYCS DFNA5 DFNA5L ELA2 ELANE GRB GSDMD GSDMDC1 GSDME GZMB HMG1 HMGB1 ICERE1 ICH2 ICH3 IGIF IL18 IL1A IL1B IL1BC IL1BCE IL1F1 IL1F2 IL1F4 IRF1 IRF2 KET NEDF P53 P63 P73H P73L SHAX1 SHAX2 SHAX3 TP53 TP63 TP73L VPS20 VPS24
Pyruvate metabolism	Alanine aminotransferase 1 L-lactate dehydrogenase A chain L-lactate dehydrogenase A-like 6A L-lactate dehydrogenase A-like 6B L-lactate dehydrogenase B chain L-lactate dehydrogenase C chain Lactoylglutathione lyase Mitochondrial pyruvate carrier 1-like protein Mitochondrial pyruvate carrier 1 Mitochondrial pyruvate carrier 2 NAD-dependent malic enzyme, mitochondrial NADP-dependent malic enzyme, mitochondrial NADP-dependent malic enzyme Oxaloacetate decarboxylase, mitochondrial Pyruvate carboxylase, mitochondrial Voltage-dependent anion-selective channel protein 1	O95563 P00338 P07195 P07864 P0DKB6 P11498 P21796 P23368 P24298 P48163 Q04760 Q16798 Q6P587 Q6ZMR3 Q9BYZ2 Q9Y5U8	AAT1 BRP44 BRP44L C16orf36 FAHD1 GLO1 GPT GPT1 LDH3 LDHA LDHAL6 LDHAL6A LDHAL6B LDHB LDHC LDHL LDHL2 LDHX ME1 ME2 ME3 MPC1 MPC1L MPC2 PC VDAC VDAC1 YISKL
RA biosynthesis pathway	2-aminomuconic semialdehyde dehydrogenase Alcohol dehydrogenase 1A Alcohol dehydrogenase 1C Aldehyde dehydrogenase 1A1 Aldo-keto reductase family 1 member C3 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Cellular retinoic acid-binding protein 1 Cytochrome P450 26A1 Cytochrome P450 26B1 Cytochrome P450 26C1 Dehydrogenase/reductase SDR family member 4 Dehydrogenase/reductase SDR family member 9 Epidermal retinol dehydrogenase 2 Retinal dehydrogenase 2 Retinaldehyde dehydrogenase 3 Retinol dehydrogenase 10 Retinol dehydrogenase 11 Retinol dehydrogenase 13 Retinol dehydrogenase 14 Retinol dehydrogenase 16 Retinol dehydrogenase 5 Short-chain dehydrogenase/reductase 3	O43174 O75452 O75911 O94788 P00326 P00352 P07327 P08319 P29762 P42330 P47895 Q6V0L0 Q8IZV5 Q8N3Y7 Q8NBN7 Q8TC12 Q92781 Q9BPW9 Q9BTZ2 Q9H2A2 Q9HBH5 Q9NR63	ADH1 ADH1A ADH1C ADH2 ADH3 ADH4 AKR1C3 ALDC ALDH1 ALDH12 ALDH1A1 ALDH1A2 ALDH1A3 ALDH6 ALDH8A1 ARSDR1 CRABP1 CYP26 CYP26A1 CYP26A2 CYP26B1 CYP26C1 DDH1 DHRS3 DHRS4 DHRS9 HSD17B5 HSD17B9 KIAA0119 P450RAI1 P450RAI2 PAN2 PGFS PSDR1 PUMB1 RALDH2 RBP5 RDH1 RDH10 RDH11 RDH13 RDH14 RDH15 RDH16 RDH17 RDH5 RDHE2 RODH4 SDR16C1 SDR16C4 SDR16C5 SDR25C2 SDR7C1 SDR7C3 SDR7C4 SDR9C4 SDR9C5 SDR9C8
RAB GEFs exchange GTP for GDP on RABs	14-3-3 protein epsilon ALS2 C-terminal-like protein Alsin Ankyrin repeat domain-containing protein 27 BLOC-3 complex member HPS1 BLOC-3 complex member HPS4 C-myc promoter-binding protein DENN domain-containing protein 1A DENN domain-containing protein 1B DENN domain-containing protein 1C DENN domain-containing protein 2A DENN domain-containing protein 2B DENN domain-containing protein 2C DENN domain-containing protein 2D DENN domain-containing protein 3 DENN domain-containing protein 4B DENN domain-containing protein 4C DENN domain-containing protein 5A DENN domain-containing protein 5B GTPase-activating protein and VPS9 domain-containing protein 1 Guanine nucleotide exchange factor for Rab-3A Guanine nucleotide exchange factor subunit RIC1 Myotubularin-related protein 13 Myotubularin-related protein 5 Protein DENND6A Protein DENND6B RAB6A-GEF complex partner protein 2 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rab GDP dissociation inhibitor alpha Rab GDP dissociation inhibitor beta Rab proteins geranylgeranyltransferase component A 1 Rab proteins geranylgeranyltransferase component A 2 Rab-3A-interacting protein Rab3 GTPase-activating protein catalytic subunit Rab3 GTPase-activating protein non-catalytic subunit Rab5 GDP/GTP exchange factor Ras and Rab interactor 1 Ras and Rab interactor 2 Ras and Rab interactor 3 Ras and Rab interactor-like protein Ras-related protein Rab-10 Ras-related protein Rab-12 Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-18 Ras-related protein Rab-1A Ras-related protein Rab-1B Ras-related protein Rab-21 Ras-related protein Rab-27A Ras-related protein Rab-27B Ras-related protein Rab-31 Ras-related protein Rab-32 Ras-related protein Rab-35 Ras-related protein Rab-38 Ras-related protein Rab-39A Ras-related protein Rab-39B Ras-related protein Rab-3A Ras-related protein Rab-5A Ras-related protein Rab-5B Ras-related protein Rab-5C Ras-related protein Rab-6A Ras-related protein Rab-6B Ras-related protein Rab-7a Ras-related protein Rab-7b Ras-related protein Rab-8A Ras-related protein Rab-8B Ras-related protein Rab-9A Ras-related protein Rab-9B Serine/threonine-protein kinase ULK1 Trafficking protein particle complex subunit 10 Trafficking protein particle complex subunit 11 Trafficking protein particle complex subunit 12 Trafficking protein particle complex subunit 13 Trafficking protein particle complex subunit 1 Trafficking protein particle complex subunit 2-like protein Trafficking protein particle complex subunit 2 Trafficking protein particle complex subunit 3 Trafficking protein particle complex subunit 4 Trafficking protein particle complex subunit 5 Trafficking protein particle complex subunit 6A Trafficking protein particle complex subunit 6B Trafficking protein particle complex subunit 8 Trafficking protein particle complex subunit 9 Vacuolar fusion protein CCZ1 homolog B Vacuolar fusion protein CCZ1 homolog Vacuolar fusion protein MON1 homolog A Vacuolar fusion protein MON1 homolog B	A2RUS2 A5PLN9 O00194 O43617 O75064 O75385 O75865 O95248 P0DI81 P20336 P20339 P20340 P24386 P26374 P31150 P31749 P31751 P48553 P50395 P51148 P51149 P51151 P51153 P51159 P57729 P61006 P61020 P61026 P61106 P62258 P62820 P78524 P86790 P86791 Q13636 Q13637 Q13671 Q14964 Q14C86 Q15042 Q15286 Q4ADV7 Q5VZ89 Q60I27 Q68D51 Q6IQ22 Q6IQ26 Q6P3S1 Q6ZS11 Q6ZUT9 Q7L1V2 Q7Z392 Q7Z401 Q86SZ2 Q86VX9 Q86WG5 Q8IUR0 Q8IV53 Q8IWF6 Q8NEG7 Q8TB24 Q8TBN0 Q8TEH3 Q8WVT3 Q8WYP3 Q92546 Q92902 Q92930 Q96AH8 Q96DA2 Q96NW4 Q96Q05 Q96Q42 Q96QF0 Q9H0U4 Q9H2M9 Q9H6A0 Q9NP72 Q9NP90 Q9NQG7 Q9NRW1 Q9UJ41 Q9UL25 Q9UL33 Q9ULE3 Q9Y243 Q9Y296 Q9Y2L5 Q9Y5R8	AKT1 AKT2 AKT3 ALS2 ALS2CL ALS2CR6 ANKRD27 BET3 BET5 C1orf218 C4orf41 C5orf44 C7orf28A C7orf28B C9orf55 C9orf55B CCZ1 CCZ1B CHM CHML CIP150 CMT4B2 DENND1A DENND1B DENND1C DENND2A DENND2B DENND2C DENND2D DENND3 DENND4A DENND4B DENND4C DENND5A DENND5B DENND6A DENND6B EHOC1 FAM116A FAM116B FAM31A FAM31B FAM31C GAPEX5 GAPVD1 GDI1 GDI2 GDIL HPS HPS1 HPS4 HSRG1 HTS1 IRLB KIAA0066 KIAA0118 KIAA0258 KIAA0476 KIAA0722 KIAA0839 KIAA0870 KIAA0872 KIAA1012 KIAA1091 KIAA1277 KIAA1432 KIAA1521 KIAA1563 KIAA1608 KIAA1667 KIAA1766 KIAA1882 MEL MON1A MON1B MTMR13 MTMR5 MUM2 MYCPBP NIBP OPHN2 PKB PKBG RAB1 RAB10 RAB12 RAB13 RAB14 RAB18 RAB1A RAB1B RAB1C RAB21 RAB22B RAB27 RAB27A RAB27B RAB31 RAB32 RAB35 RAB38 RAB39 RAB39A RAB39B RAB3A RAB3GAP RAB3GAP1 RAB3GAP2 RAB3IL1 RAB3IP RAB5 RAB5A RAB5B RAB5C RAB6 RAB6A RAB6B RAB6IP1 RAB7 RAB7A RAB7B RAB8 RAB8A RAB8B RAB9 RAB9A RAB9B RAB9L RABEX5 RABGDIA RABGDIB RABGEF1 RABIN8 RABL RAC RAP6 RASSF4 RAY REP1 REP2 RGP1 RIC1 RIN1 RIN2 RIN3 RINL SAND1 SAND2 SBDN SBF1 SBF2 SEDL ST5 TCD TMEM1 TRAMM TRAPPC1 TRAPPC10 TRAPPC11 TRAPPC12 TRAPPC13 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6A TRAPPC6B TRAPPC8 TRAPPC9 TTC15 ULK1 XAP4 YWHAE
RAB geranylgeranylation	Geranylgeranyl transferase type-2 subunit alpha Geranylgeranyl transferase type-2 subunit beta Protein tyrosine phosphatase type IVA 2 Rab proteins geranylgeranyltransferase component A 1 Rab proteins geranylgeranyltransferase component A 2 Ras-related protein Rab-10 Ras-related protein Rab-11A Ras-related protein Rab-11B Ras-related protein Rab-12 Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-15 Ras-related protein Rab-17 Ras-related protein Rab-18 Ras-related protein Rab-19 Ras-related protein Rab-1A Ras-related protein Rab-1B Ras-related protein Rab-20 Ras-related protein Rab-21 Ras-related protein Rab-22A Ras-related protein Rab-23 Ras-related protein Rab-24 Ras-related protein Rab-25 Ras-related protein Rab-26 Ras-related protein Rab-27A Ras-related protein Rab-27B Ras-related protein Rab-2A Ras-related protein Rab-2B Ras-related protein Rab-30 Ras-related protein Rab-31 Ras-related protein Rab-32 Ras-related protein Rab-33A Ras-related protein Rab-33B Ras-related protein Rab-34 Ras-related protein Rab-35 Ras-related protein Rab-36 Ras-related protein Rab-37 Ras-related protein Rab-38 Ras-related protein Rab-39A Ras-related protein Rab-39B Ras-related protein Rab-3A Ras-related protein Rab-3B Ras-related protein Rab-3C Ras-related protein Rab-3D Ras-related protein Rab-40A Ras-related protein Rab-40B Ras-related protein Rab-40C Ras-related protein Rab-41 Ras-related protein Rab-42 Ras-related protein Rab-43 Ras-related protein Rab-44 Ras-related protein Rab-4A Ras-related protein Rab-4B Ras-related protein Rab-5A Ras-related protein Rab-5B Ras-related protein Rab-5C Ras-related protein Rab-6A Ras-related protein Rab-6B Ras-related protein Rab-7L1 Ras-related protein Rab-7a Ras-related protein Rab-7b Ras-related protein Rab-8A Ras-related protein Rab-8B Ras-related protein Rab-9A Ras-related protein Rab-9B	A4D1S5 O00194 O14966 O95716 O95755 P20336 P20337 P20338 P20339 P20340 P24386 P26374 P51148 P51149 P51151 P51153 P51159 P53611 P57729 P57735 P59190 P61006 P61018 P61019 P61020 P61026 P61106 P62491 P62820 Q12829 Q12974 Q13636 Q13637 Q14088 Q14964 Q15286 Q15771 Q15907 Q5JT25 Q6IQ22 Q7Z6P3 Q86YS6 Q8N4Z0 Q8WUD1 Q8WXH6 Q92696 Q92930 Q969Q5 Q96AH8 Q96AX2 Q96DA2 Q96E17 Q96S21 Q9BZG1 Q9H082 Q9H0T7 Q9H0U4 Q9NP72 Q9NP90 Q9NRW1 Q9NX57 Q9UL25 Q9UL26 Q9ULC3 Q9ULW5	CATX8 CHM CHML GGTB GOV KIAA0118 MEL PRL2 PTP4A2 PTPCAAX2 RAB1 RAB10 RAB11 RAB11A RAB11B RAB12 RAB13 RAB14 RAB15 RAB16 RAB17 RAB18 RAB19 RAB19B RAB1A RAB1B RAB1C RAB2 RAB20 RAB21 RAB22 RAB22A RAB22B RAB23 RAB24 RAB25 RAB26 RAB27 RAB27A RAB27B RAB29 RAB2A RAB2B RAB30 RAB31 RAB32 RAB33A RAB33B RAB34 RAB35 RAB36 RAB37 RAB38 RAB39 RAB39A RAB39B RAB3A RAB3B RAB3C RAB3D RAB4 RAB40A RAB40B RAB40C RAB41 RAB42 RAB43 RAB44 RAB4A RAB4B RAB5 RAB5A RAB5B RAB5C RAB6 RAB6A RAB6B RAB7 RAB7A RAB7B RAB7L1 RAB8 RAB8A RAB8B RAB9 RAB9A RAB9B RAB9L RABGGTA RABGGTB RABL RABS10 RAH RARL RASL8C RAY REP1 REP2 SEC4L TCD YPT3
RAC1 GTPase cycle	ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Abl interactor 1 Abl interactor 2 Actin nucleation-promoting factor WAS Actin nucleation-promoting factor WASL Actin remodeling regulator NHS Actin-binding protein WASF1 Actin-binding protein WASF2 Actin-binding protein WASF3 Active breakpoint cluster region-related protein Alsin Amphoterin-induced protein 2 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 BAR/IMD domain-containing adapter protein 2-like 1 BAR/IMD domain-containing adapter protein 2 Beta-chimaerin Breakpoint cluster region protein Caveolin-1 Cdc42 effector protein 1 Cdc42 effector protein 4 Cell division control protein 42 homolog Cell surface glycoprotein MUC18 Citron Rho-interacting kinase Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytoplasmic FMR1-interacting protein 1 Cytoplasmic FMR1-interacting protein 2 DEP domain-containing protein 1B Dedicator of cytokinesis protein 10 Dedicator of cytokinesis protein 11 Dedicator of cytokinesis protein 1 Dedicator of cytokinesis protein 2 Dedicator of cytokinesis protein 3 Dedicator of cytokinesis protein 4 Dedicator of cytokinesis protein 5 Dedicator of cytokinesis protein 6 Dedicator of cytokinesis protein 7 Dedicator of cytokinesis protein 8 Dedicator of cytokinesis protein 9 Delta(14)-sterol reductase LBR Differentially expressed in FDCP 6 homolog Emerin Ephexin-1 Ephrin type-A receptor 2 Erbin Extended synaptotagmin-1 FERM, ARHGEF and pleckstrin domain-containing protein 1 FERM, ARHGEF and pleckstrin domain-containing protein 2 FYVE, RhoGEF and PH domain-containing protein 5 Fermitin family homolog 2 Formin-like protein 1 GEM-interacting protein Granule associated Rac and RHOG effector protein 1 Guanine nucleotide exchange factor DBS Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Guanine nucleotide-binding protein subunit alpha-13 Inner nuclear membrane protein Man1 Integrin beta-1 Kalirin Kinectin Lamina-associated polypeptide 2, isoforms beta/gamma MAGUK p55 subfamily member 7 N-chimaerin NADPH oxidase 1 NADPH oxidase 3 NADPH oxidase activator 1 NADPH oxidase organizer 1 Nck-associated protein 1-like Nck-associated protein 1 Neutral amino acid transporter B(0) Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Neutrophil cytosol factor 4 Nischarin Oligophrenin-1 Partitioning defective 6 homolog alpha Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phospholipase D1 Phospholipase D2 Pleckstrin homology domain-containing family G member 1 Pleckstrin homology domain-containing family G member 2 Pleckstrin homology domain-containing family G member 3 Pleckstrin homology domain-containing family G member 6 Protein BRICK1 Protein ECT2 Protein FAM13A Protein FAM13B Protein diaphanous homolog 3 Protein jagged-1 Proto-oncogene DBL Proto-oncogene vav Puratrophin-1 Rac GTPase-activating protein 1 Ragulator complex protein LAMTOR1 RalA-binding protein 1 Ras GTPase-activating-like protein IQGAP1 Ras GTPase-activating-like protein IQGAP2 Ras GTPase-activating-like protein IQGAP3 Ras-related C3 botulinum toxin substrate 1 Ras-related protein Rab-7a Ras-specific guanine nucleotide-releasing factor 2 Rho GDP-dissociation inhibitor 1 Rho GDP-dissociation inhibitor 2 Rho GTPase-activating protein 10 Rho GTPase-activating protein 12 Rho GTPase-activating protein 15 Rho GTPase-activating protein 17 Rho GTPase-activating protein 1 Rho GTPase-activating protein 20 Rho GTPase-activating protein 21 Rho GTPase-activating protein 22 Rho GTPase-activating protein 23 Rho GTPase-activating protein 24 Rho GTPase-activating protein 25 Rho GTPase-activating protein 26 Rho GTPase-activating protein 27 Rho GTPase-activating protein 29 Rho GTPase-activating protein 30 Rho GTPase-activating protein 31 Rho GTPase-activating protein 32 Rho GTPase-activating protein 33 Rho GTPase-activating protein 35 Rho GTPase-activating protein 39 Rho GTPase-activating protein 42 Rho GTPase-activating protein 44 Rho GTPase-activating protein 45 Rho GTPase-activating protein 4 Rho GTPase-activating protein 5 Rho GTPase-activating protein 7 Rho GTPase-activating protein 9 Rho GTPase-activating protein SYDE2 Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 15 Rho guanine nucleotide exchange factor 18 Rho guanine nucleotide exchange factor 19 Rho guanine nucleotide exchange factor 25 Rho guanine nucleotide exchange factor 39 Rho guanine nucleotide exchange factor 4 Rho guanine nucleotide exchange factor 5 Rho guanine nucleotide exchange factor 6 Rho guanine nucleotide exchange factor 7 Rho guanine nucleotide exchange factor TIAM1 Rho guanine nucleotide exchange factor TIAM2 SH3 domain-binding protein 1 SLIT-ROBO Rho GTPase-activating protein 1 SLIT-ROBO Rho GTPase-activating protein 2 SLIT-ROBO Rho GTPase-activating protein 3 Serine/threonine-protein kinase MRCK alpha Serine/threonine-protein kinase N1 Serine/threonine-protein kinase N2 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase PAK 4 Serine/threonine-protein kinase PAK 5 Serine/threonine-protein kinase PAK 6 Serine/threonine-protein kinase TAO3 Serine/threonine-protein kinase VRK2 Son of sevenless homolog 1 Son of sevenless homolog 2 Spermatogenesis-associated protein 13 Switch-associated protein 70 Synaptobrevin homolog YKT6 Synaptosomal-associated protein 23 T-cell activation Rho GTPase-activating protein Transferrin receptor protein 1 Triple functional domain protein Tyrosine-protein kinase ABL2 Unconventional myosin-IXb Vang-like protein 1 Vesicle-associated membrane protein 3 WAS/WASL-interacting protein family member 1 WAS/WASL-interacting protein family member 2 WAS/WASL-interacting protein family member 3	A1A4S6 A1L390 A6NGB9 A6NI28 A7KAX9 O00161 O00401 O00459 O14559 O14578 O14827 O14939 O15013 O15063 O15068 O15085 O15498 O43295 O43516 O60229 O60890 O75044 O75914 O75962 O94887 O94988 O94989 O95466 O96013 P02786 P04839 P05556 P10911 P11274 P13498 P14598 P15498 P15882 P19878 P27986 P29317 P42167 P42331 P42336 P42684 P42768 P43121 P46940 P50402 P51149 P52565 P52566 P52735 P52757 P55160 P60953 P63000 P78504 P98171 Q00587 Q03135 Q07889 Q07890 Q07960 Q12774 Q12979 Q13009 Q13017 Q13153 Q13177 Q13393 Q13459 Q13576 Q14155 Q14161 Q14185 Q14344 Q14739 Q15052 Q15080 Q15311 Q15758 Q15836 Q16512 Q16513 Q17R89 Q2M1Z3 Q3KR16 Q52LW3 Q53QZ3 Q58EX7 Q5JSL3 Q5T2T1 Q5T5U3 Q5VT25 Q5VT97 Q68EM7 Q6IAA8 Q6T4R5 Q6ZNL6 Q6ZSZ5 Q6ZUM4 Q70Z35 Q7L576 Q7Z5H3 Q7Z6B7 Q7Z6I6 Q86SJ2 Q86UP2 Q86UR1 Q86VI3 Q86VW2 Q86Y07 Q8IVF5 Q8IW93 Q8IWW6 Q8IZD9 Q8IZP0 Q8N103 Q8N1I0 Q8N264 Q8N4T4 Q8N5V2 Q8NF50 Q8NFA2 Q8TAA9 Q8TCU6 Q8TF74 Q8WUW1 Q8WUY9 Q8WWN8 Q8WZ64 Q92558 Q92569 Q92608 Q92619 Q96AC1 Q96BY6 Q96F07 Q96HP0 Q96N67 Q96N96 Q96P48 Q96Q42 Q96QB1 Q96RT1 Q9BRR9 Q9BSJ8 Q9BZ29 Q9C0H5 Q9H0H5 Q9H2K8 Q9H3Q1 Q9H4E7 Q9H7D0 Q9H7P9 Q9H8V3 Q9HBY0 Q9NPB6 Q9NQU5 Q9NR80 Q9NRY4 Q9NSV4 Q9NYB9 Q9NYF5 Q9P107 Q9P227 Q9P286 Q9P2F6 Q9UH65 Q9UHR4 Q9UKW4 Q9ULL1 Q9UNA1 Q9UPY6 Q9UQB8 Q9Y2A7 Q9Y2I1 Q9Y2U8 Q9Y2X7 Q9Y3L3 Q9Y4F1 Q9Y5S8 Q9Y6W5	ABI1 ABI2 ABL2 ABLL ABR ALI1 ALS2 ALS2CR6 AMIGO2 ARAP1 ARAP2 ARAP3 ARG ARGBPIA ARHGAP1 ARHGAP10 ARHGAP12 ARHGAP13 ARHGAP14 ARHGAP15 ARHGAP17 ARHGAP2 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP25 ARHGAP26 ARHGAP27 ARHGAP29 ARHGAP3 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP34 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP42 ARHGAP44 ARHGAP45 ARHGAP5 ARHGAP7 ARHGAP9 ARHGDIA ARHGDIB ARHGEF10 ARHGEF11 ARHGEF15 ARHGEF18 ARHGEF19 ARHGEF25 ARHGEF39 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ASCT2 BAIAP2 BAIAP2L1 BCH BCR BCR1 BORG4 BORG5 BRK1 C11orf59 C17orf1 C17orf1B C3orf10 C5orf5 C9orf100 CAMGAP1 CAV CAV1 CDC42 CDC42BPA CDC42EP1 CDC42EP4 CDC42GAP CDEP CDGAP CENTD1 CENTD2 CENTD3 CEP1 CEP4 CG1 CHN CHN1 CHN2 CIT COOL1 COOL2 CR16 CRIK CYBA CYBB CYFIP1 CYFIP2 D22S11 DBL DEF6 DEPDC1B DEPDC2 DIAP3 DIAPH3 DLC1 DOCK1 DOCK10 DOCK11 DOCK2 DOCK3 DOCK4 DOCK5 DOCK6 DOCK7 DOCK8 DOCK9 DPK DUET DUO ECK ECT2 EDMD EMD EPHA2 ERBB2IP ERBIN ESYT1 FAM13A FAM13A1 FAM13B FAM13B1 FAM62A FARP1 FARP2 FERMT2 FGD5 FILGAP FMNL FMNL1 FNBP2 FNRB FRL1 GARRE1 GDIA1 GDIA2 GDID4 GEFT GIT1 GIT2 GMIP GNA13 GRAF GRAF2 GRAF3 GRB1 GRF1 GRF2 GRIT GRLF1 HAPIP HEM1 HEM2 HMHA1 IBP IMD2 IQGAP1 IQGAP2 IQGAP3 IRAS IRTKS ITGB1 JAG1 JAGL1 JIK KALRN KDS KIAA0004 KIAA0006 KIAA0051 KIAA0053 KIAA0068 KIAA0131 KIAA0142 KIAA0148 KIAA0209 KIAA0223 KIAA0269 KIAA0294 KIAA0299 KIAA0355 KIAA0362 KIAA0380 KIAA0411 KIAA0451 KIAA0456 KIAA0521 KIAA0580 KIAA0587 KIAA0599 KIAA0621 KIAA0640 KIAA0672 KIAA0694 KIAA0712 KIAA0716 KIAA0747 KIAA0782 KIAA0793 KIAA0900 KIAA0914 KIAA0915 KIAA0949 KIAA0975 KIAA1058 KIAA1112 KIAA1142 KIAA1156 KIAA1168 KIAA1204 KIAA1209 KIAA1225 KIAA1264 KIAA1304 KIAA1391 KIAA1395 KIAA1415 KIAA1424 KIAA1478 KIAA1501 KIAA1563 KIAA1688 KIAA1722 KIAA1723 KIAA1771 KIAA2016 KIND2 KTN1 LAMTOR1 LAP2 LBR LEMD3 M7V1 MAN1 MAP3K18 MBC2 MCAM MCF2 MCF2L MDF2 MEGAP MGCRACGAP MIG2 MOCA MOX1 MOX2 MPP7 MSE55 MSK12 MUC18 MYO9B MYR5 NAP1 NCF1 NCF2 NCF4 NCKAP1 NCKAP1L NGEF NHS NISCH NOH1 NOX1 NOX2 NOX3 NOXA1 NOXA2 NOXO1 NOXO2 OPHN1 OPHN1L OPHN3 OST P190A P41NOX P51NOX P67PHOX P85SPR PAK1 PAK2 PAK3 PAK3BP PAK4 PAK5 PAK6 PAK7 PAR6A PARD6A PARG1 PDRO PIK3CA PIK3R1 PIK3R2 PIK3R3 PIR121 PIXA PIXB PKN PKN1 PKN2 PLD1 PLD2 PLEKHC1 PLEKHC2 PLEKHC3 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG6 PREX1 PREX2 PRK1 PRK2 PRKCL1 PRKCL2 PRTPHN1 RAB7 RAB7A RAC1 RACGAP1 RALBP1 RAP1GN1 RASGRF2 RDR RDRC RGC1 RHOGAP1 RHOGAP2 RHOGAP4 RHOGAP5 RICH1 RICH2 RICS RLIP RLIP1 RLIP76 SCAR1 SCAR3 SH3BP1 SH3D20 SH3PXD1A SH3PXD4 SH3PXD5 SLC1A5 SNAP23 SNX26 SOS1 SOS2 SPATA13 SRGAP1 SRGAP2 SRGAP2A SRGAP3 SSH3BP1 STA STARD12 STB2 STEF STK21 SWAP70 SYB3 SYDE2 TAGAP TAGAP1 TAOK3 TC25 TCGAP TFRC TIAM1 TIAM2 TIM TMEM133 TMPO TRAD TRIO VAMP3 VANGL1 VAV VAV1 VAV2 VAV3 VRK2 WAS WASF1 WASF2 WASF3 WASL WASPIP WAVE1 WAVE2 WAVE3 WICH WIP WIPF1 WIPF2 WIPF3 WIRE XTP8 YKT6 ZFYVE23 ZIZ1 ZIZ2 ZIZ3 p190ARHOGAP
RAC2 GTPase cycle	ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Abl interactor 1 Abl interactor 2 Actin remodeling regulator NHS Actin-binding protein WASF2 Active breakpoint cluster region-related protein Ankyrin repeat and LEM domain-containing protein 2 Armadillo repeat-containing X-linked protein 3 BAR/IMD domain-containing adapter protein 2-like 1 Breakpoint cluster region protein Caveolin-1 Cdc42 effector protein 1 Cdc42 effector protein 4 Cell division control protein 42 homolog Cell surface glycoprotein MUC18 Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytoplasmic FMR1-interacting protein 1 DEP domain-containing protein 1B Dedicator of cytokinesis protein 10 Dedicator of cytokinesis protein 1 Dedicator of cytokinesis protein 2 Dedicator of cytokinesis protein 3 Dedicator of cytokinesis protein 4 Delta(14)-sterol reductase LBR Desmoglein-2 Differentially expressed in FDCP 6 homolog Emerin Ephrin type-A receptor 2 Erbin Extended synaptotagmin-1 Granule associated Rac and RHOG effector protein 1 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Inner nuclear membrane protein Man1 Integrin beta-1 Lamina-associated polypeptide 2, isoforms beta/gamma MAGUK p55 subfamily member 7 Membrane-associated progesterone receptor component 2 Metaxin-1 Nck-associated protein 1-like Nck-associated protein 1 Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Neutrophil cytosol factor 4 Oligophrenin-1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phospholipase D2 Protein BRICK1 Protein ERGIC-53 Protein diaphanous homolog 3 Proto-oncogene DBL Proto-oncogene vav Rac GTPase-activating protein 1 Ragulator complex protein LAMTOR1 Ras GTPase-activating-like protein IQGAP1 Ras-related C3 botulinum toxin substrate 2 Ras-related protein Rab-7a Rho GDP-dissociation inhibitor 1 Rho GTPase-activating protein 17 Rho GTPase-activating protein 1 Rho GTPase-activating protein 21 Rho GTPase-activating protein 26 Rho GTPase-activating protein 32 Rho GTPase-activating protein 35 Rho GTPase-activating protein 39 Rho GTPase-activating protein 42 Rho GTPase-activating protein SYDE1 Rho guanine nucleotide exchange factor TIAM1 SLIT and NTRK-like protein 5 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 4 Serine/threonine-protein kinase TAO3 Serine/threonine-protein kinase VRK2 Sorting and assembly machinery component 50 homolog Starch-binding domain-containing protein 1 Switch-associated protein 70 Transferrin receptor protein 1 Triple functional domain protein Vang-like protein 1 Vesicle-associated membrane protein 3 Vesicle-associated membrane protein-associated protein B/C	A6NI28 A7KAX9 O00459 O14939 O15063 O15173 O60890 O75962 O94991 O95210 O95292 O96013 P02786 P04839 P05556 P10911 P11274 P13498 P14598 P15153 P15498 P19878 P27986 P29317 P42167 P42336 P43121 P46940 P49257 P50402 P51149 P52565 P52735 P55160 P60953 Q00587 Q03135 Q07960 Q12979 Q13009 Q13153 Q13177 Q13505 Q14126 Q14161 Q14185 Q14739 Q15080 Q15836 Q5T2T1 Q5T5U3 Q68EM7 Q6IAA8 Q6T4R5 Q6ZW31 Q7L576 Q86XL3 Q86Y07 Q8IZD9 Q8IZP0 Q8N1I0 Q8TAA9 Q8TCU6 Q8WUW1 Q8WUY9 Q92569 Q92608 Q96BY6 Q96RT1 Q9BSJ8 Q9C0H5 Q9H0H5 Q9H2K8 Q9H3Q1 Q9H4E7 Q9NRY4 Q9NSV4 Q9NYB9 Q9UH62 Q9UH65 Q9UHR4 Q9UKW4 Q9UNA1 Q9Y2A7 Q9Y2U8 Q9Y2X7 Q9Y512 Q9Y6W5	ABI1 ABI2 ABR ALEX3 ANKLE2 ARGBPIA ARHGAP1 ARHGAP10 ARHGAP17 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP42 ARHGDIA ARMCX3 BAIAP2L1 BCR BCR1 BORG4 BORG5 BRK1 C11orf59 C3orf10 CAV CAV1 CDC42 CDC42EP1 CDC42EP4 CDC42GAP CDHF5 CEP1 CEP4 CYBA CYBB CYFIP1 D22S11 DBL DEF6 DEPDC1B DG6 DIAP3 DIAPH3 DOCK1 DOCK10 DOCK2 DOCK3 DOCK4 DPK DSG2 ECK EDMD EMD EPHA2 ERBB2IP ERBIN ERGIC53 ESYT1 F5F8D FAM62A FNRB GARRE1 GDIA1 GIT1 GIT2 GRAF GRAF3 GRB1 GRF1 GRIT GRLF1 HEM1 HEM2 IBP IQGAP1 IRTKS ITGB1 JIK KDS KIAA0051 KIAA0068 KIAA0148 KIAA0209 KIAA0299 KIAA0355 KIAA0587 KIAA0621 KIAA0640 KIAA0692 KIAA0694 KIAA0712 KIAA0716 KIAA0747 KIAA0918 KIAA1142 KIAA1225 KIAA1415 KIAA1424 KIAA1478 KIAA1688 KIAA1722 LAMTOR1 LAP2 LBR LEM4 LEMD3 LMAN1 LRRC11 MAN1 MAP3K18 MBC2 MCAM MCF2 MDF2 MGCRACGAP MOCA MPP7 MSE55 MSK12 MTX MTX1 MTXN MUC18 NAP1 NCF1 NCF2 NCF4 NCKAP1 NCKAP1L NHS NOX2 NOXA2 NOXO2 OPHN1 OPHN1L P190A P67PHOX PAK1 PAK2 PAK4 PDRO PGRMC2 PIK3CA PIK3R1 PIK3R2 PIK3R3 PLD2 PMBP PREX1 RAB7 RAB7A RAC2 RACGAP1 RHOGAP1 RICH1 RICS SAM50 SAMM50 SH3PXD1A SH3PXD4 SLITRK5 SSH3BP1 STA STB2 STBD1 SWAP70 SYB3 SYDE1 TAOK3 TFRC TIAM1 TMEM133 TMPO TRIO VAMP3 VANGL1 VAPB VAV VAV1 VAV2 VAV3 VRK2 WASF2 WAVE2 XTP8 ZIZ3 p190ARHOGAP
RAC3 GTPase cycle	ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Abl interactor 1 Abl interactor 2 Actin remodeling regulator NHS Actin-binding protein WASF1 Actin-binding protein WASF2 Active breakpoint cluster region-related protein Amphoterin-induced protein 2 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 BAR/IMD domain-containing adapter protein 2-like 1 BAR/IMD domain-containing adapter protein 2 Breakpoint cluster region protein Caveolin-1 Cdc42 effector protein 1 Cell division control protein 42 homolog Cell surface glycoprotein MUC18 Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytoplasmic FMR1-interacting protein 1 DEP domain-containing protein 1B Dedicator of cytokinesis protein 10 Delta(14)-sterol reductase LBR Desmoglein-2 Emerin Ephrin type-A receptor 2 Erbin Extended synaptotagmin-1 Fermitin family homolog 2 Granule associated Rac and RHOG effector protein 1 Guanine nucleotide exchange factor VAV2 Inner nuclear membrane protein Man1 Inositol polyphosphate 5-phosphatase OCRL Integrin beta-1 Interleukin-32 Lamina-associated polypeptide 2, isoforms beta/gamma MAGUK p55 subfamily member 7 Membrane-associated progesterone receptor component 2 NADPH oxidase 1 NADPH oxidase 3 NADPH oxidase activator 1 NADPH oxidase organizer 1 Nck-associated protein 1-like Nck-associated protein 1 Neutral amino acid transporter B(0) Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Neutrophil cytosol factor 4 Oligophrenin-1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Protein BRICK1 Protein ERGIC-53 Protein diaphanous homolog 3 Protein jagged-1 Proto-oncogene DBL Rac GTPase-activating protein 1 Ragulator complex protein LAMTOR1 Rap guanine nucleotide exchange factor 1 Ras-related C3 botulinum toxin substrate 3 Ras-related protein Rab-7a Rho GDP-dissociation inhibitor 2 Rho GTPase-activating protein 15 Rho GTPase-activating protein 17 Rho GTPase-activating protein 1 Rho GTPase-activating protein 21 Rho GTPase-activating protein 26 Rho GTPase-activating protein 32 Rho GTPase-activating protein 35 Rho GTPase-activating protein 39 Rho GTPase-activating protein 42 Rho GTPase-activating protein 5 Rho GTPase-activating protein 6 Rho GTPase-activating protein SYDE1 Rho guanine nucleotide exchange factor TIAM1 SLIT and NTRK-like protein 3 SLIT and NTRK-like protein 5 SLIT-ROBO Rho GTPase-activating protein 2 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 4 Serine/threonine-protein kinase TAO3 Serine/threonine-protein kinase VRK2 Starch-binding domain-containing protein 1 Switch-associated protein 70 Synaptobrevin homolog YKT6 Synaptosomal-associated protein 23 Transferrin receptor protein 1 Triple functional domain protein Tyrosine-protein kinase ABL2 Vang-like protein 1 Vesicle-associated membrane protein 3	A6NI28 A7KAX9 O00161 O00459 O15063 O15173 O15498 O43182 O60890 O75044 O75962 O94933 O94991 O95210 O96013 P02786 P04839 P05556 P10911 P11274 P13498 P14598 P19878 P24001 P27986 P29317 P42167 P42684 P43121 P49257 P50402 P51149 P52566 P52735 P55160 P60763 P60953 P78504 Q00587 Q01968 Q03135 Q07960 Q12979 Q13009 Q13017 Q13153 Q13177 Q13905 Q14126 Q14161 Q14739 Q15080 Q15758 Q15836 Q53QZ3 Q5T2T1 Q5T5U3 Q68EM7 Q6IAA8 Q6T4R5 Q6ZW31 Q7L576 Q86SJ2 Q86UR1 Q86Y07 Q8IZP0 Q8NFA2 Q8TAA9 Q8TCU6 Q8WUW1 Q8WUY9 Q8WWN8 Q8WZ64 Q92558 Q96AC1 Q96BY6 Q96RT1 Q9BSJ8 Q9C0H5 Q9H0H5 Q9H2K8 Q9HBY0 Q9NRY4 Q9NSV4 Q9NYB9 Q9UH65 Q9UHR4 Q9UNA1 Q9UQB8 Q9Y2A7 Q9Y2U8 Q9Y2X7 Q9Y5S8 Q9Y6W5	ABI1 ABI2 ABL2 ABLL ABR ALI1 AMIGO2 ARAP2 ARAP3 ARG ARGBPIA ARHGAP1 ARHGAP10 ARHGAP15 ARHGAP17 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP34 ARHGAP35 ARHGAP39 ARHGAP42 ARHGAP5 ARHGAP6 ARHGDIB ASCT2 BAIAP2 BAIAP2L1 BCR BCR1 BORG5 BRK1 C11orf59 C3orf10 CAV CAV1 CDC42 CDC42EP1 CDC42GAP CDHF5 CENTD1 CENTD3 CEP1 CYBA CYBB CYFIP1 D22S11 DBL DEPDC1B DG6 DIAP3 DIAPH3 DOCK10 DPK DSG2 ECK EDMD EMD EPHA2 ERBB2IP ERBIN ERGIC53 ESYT1 F5F8D FAM62A FERMT2 FNBP2 FNRB GARRE1 GDIA2 GDID4 GIT1 GIT2 GRAF GRAF3 GRB1 GRF1 GRF2 GRIT GRLF1 HEM1 HEM2 IL32 IRTKS ITGB1 JAG1 JAGL1 JIK KDS KIAA0068 KIAA0148 KIAA0269 KIAA0355 KIAA0456 KIAA0580 KIAA0587 KIAA0621 KIAA0640 KIAA0694 KIAA0712 KIAA0747 KIAA0848 KIAA0918 KIAA1142 KIAA1225 KIAA1415 KIAA1424 KIAA1478 KIAA1688 KIAA1722 KIND2 LAMTOR1 LAP2 LBR LEMD3 LMAN1 LRRC11 M7V1 MAN1 MAP3K18 MBC2 MCAM MCF2 MDF2 MGCRACGAP MIG2 MOX1 MOX2 MPP7 MSE55 MSK12 MUC18 NAP1 NCF1 NCF2 NCF4 NCKAP1 NCKAP1L NHS NK4 NOH1 NOX1 NOX2 NOX3 NOXA1 NOXA2 NOXO1 NOXO2 OCRL OCRL1 OPHN1 OPHN1L P190A P41NOX P51NOX P67PHOX PAK1 PAK2 PAK4 PDRO PGRMC2 PIK3R1 PIK3R2 PLEKHC1 PMBP PREX1 RAB7 RAB7A RAC3 RACGAP1 RAP1GN1 RAPGEF1 RDR RDRC RHOGAP1 RHOGAP5 RHOGAP6 RICH1 RICS SCAR1 SH3PXD1A SH3PXD4 SH3PXD5 SLC1A5 SLITRK3 SLITRK5 SNAP23 SRGAP2 SRGAP2A SSH3BP1 STA STB2 STBD1 SWAP70 SYB3 SYDE1 TAIF TAOK3 TFRC TIAM1 TMEM133 TMPO TRIO VAMP3 VANGL1 VAV2 VRK2 WASF1 WASF2 WAVE1 WAVE2 XTP8 YKT6 ZIZ3 p190ARHOGAP
RAF activation	14-3-3 protein beta/alpha BRCA1-associated protein Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 GTPase HRas GTPase NRas Kinase suppressor of Ras 1 Leucine-rich repeat protein SHOC-2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase kinase kinase 11 Prohibitin 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras-related protein M-Ras Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Tyrosine-protein kinase JAK2	O14807 O60674 P01111 P01112 P04049 P0DP23 P10398 P12931 P15056 P27448 P30153 P30154 P31946 P35232 P36507 P36873 P62140 P62714 P67775 Q02750 Q13362 Q13554 Q13555 Q13557 Q14738 Q15172 Q15173 Q16537 Q16584 Q7Z569 Q8IVT5 Q9UQ13 Q9UQM7	ARAF ARAF1 BRAF BRAF1 BRAP CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CTAK1 EMK2 HRAS HRAS1 JAK2 KIAA0044 KIAA0862 KIAA0968 KSR KSR1 MAP2K1 MAP2K2 MAP3K11 MARK3 MEK1 MEK2 MKK2 MLK3 MRAS NRAS PHB PHB1 PKS PKS2 PPP1CB PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKMK1 PRKMK2 PTK1 RAF RAF1 RAFB1 RNF52 RRAS3 SHOC2 SPRK SRC SRC1 YWHAB
RAF-independent MAPK1/3 activation	Astrocytic phosphoprotein PEA-15 Dual specificity protein phosphatase 10 Dual specificity protein phosphatase 16 Dual specificity protein phosphatase 1 Dual specificity protein phosphatase 2 Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 5 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Dual specificity protein phosphatase 8 Dual specificity protein phosphatase 9 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3	P27361 P28482 P28562 Q05923 Q13115 Q13202 Q15121 Q16690 Q16828 Q16829 Q99956 Q9BY84 Q9Y6W6	C11orf81 CL100 DUSP1 DUSP10 DUSP16 DUSP2 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 ERK1 ERK2 KIAA1700 MAPK1 MAPK3 MKP1 MKP2 MKP3 MKP4 MKP5 MKP7 PAC1 PEA15 PRKM1 PRKM2 PRKM3 PTPN10 PYST1 PYST2 VH1 VH2 VH3 VH5
RAF/MAP kinase cascade	Alpha-actinin-2 Amphiregulin Angiopoietin-1 receptor Angiopoietin-1 Artemin Astrocytic phosphoprotein PEA-15 Beta-klotho Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Cytokine receptor common subunit beta Cytokine receptor common subunit gamma Disks large homolog 1 Disks large homolog 2 Disks large homolog 3 Disks large homolog 4 Epidermal growth factor receptor Epigen Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Fms-related tyrosine kinase 3 ligand Focal adhesion kinase 1 GDNF family receptor alpha-1 GDNF family receptor alpha-2 GDNF family receptor alpha-3 GDNF family receptor alpha-4 GTPase HRas GTPase NRas Glial cell line-derived neurotrophic factor Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic, NMDA 2D Granulocyte-macrophage colony-stimulating factor receptor subunit alpha Granulocyte-macrophage colony-stimulating factor Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 Interleukin-3 receptor subunit alpha Interleukin-3 Interleukin-5 receptor subunit alpha Interleukin-5 Leucine-rich repeat-containing protein 7 Mast/stem cell growth factor receptor Kit Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Neural cell adhesion molecule 1 Neurofilament light polypeptide Neurturin Persephin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase receptor Ret Protransforming growth factor alpha RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 4 Ral guanine nucleotide dissociation stimulator-like 1 Ral guanine nucleotide dissociation stimulator-like 2 Ral guanine nucleotide dissociation stimulator-like 3 Ral guanine nucleotide dissociation stimulator Ran-binding protein 9 Rap guanine nucleotide exchange factor 2 Ras guanyl-releasing protein 3 Ras-GEF domain-containing family member 1A Ras-specific guanine nucleotide-releasing factor 1 Ras-specific guanine nucleotide-releasing factor 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Receptor-type tyrosine-protein phosphatase alpha SHC-transforming protein 1 SHC-transforming protein 2 SHC-transforming protein 3 Son of sevenless homolog 1 Spectrin alpha chain, erythrocytic 1 Spectrin alpha chain, non-erythrocytic 1 Spectrin beta chain, erythrocytic Spectrin beta chain, non-erythrocytic 1 Spectrin beta chain, non-erythrocytic 2 Spectrin beta chain, non-erythrocytic 4 Spectrin beta chain, non-erythrocytic 5 Tyrosine-protein kinase Fyn Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	O00451 O00459 O14511 O14827 O14944 O15020 O15211 O15399 O15520 O43320 O43559 O60542 O60609 O60674 O76093 O95267 O95750 P00533 P01111 P01112 P01127 P01133 P01135 P01589 P02549 P04141 P04626 P05113 P05230 P06241 P07196 P07949 P08581 P08620 P08700 P09038 P09619 P0DP23 P10721 P10767 P11277 P11487 P13591 P14210 P14784 P15509 P15514 P16234 P18433 P21781 P22455 P23458 P26951 P27361 P27986 P28482 P29353 P31371 P31785 P32927 P35070 P35568 P35609 P36888 P39905 P42336 P42338 P49771 P52333 P56159 P56975 P60568 P78352 P98077 Q01082 Q01344 Q02297 Q02763 Q05397 Q05586 Q07889 Q12959 Q12967 Q13224 Q13554 Q13555 Q13557 Q13813 Q13972 Q15121 Q15389 Q15700 Q3MIN7 Q5T4W7 Q6UW88 Q86Z14 Q8IV61 Q8N9B8 Q8TDF6 Q8WU20 Q8WWG1 Q92529 Q92796 Q96NW7 Q96S59 Q99075 Q99748 Q9GZV9 Q9GZZ7 Q9H254 Q9HCT0 Q9NP95 Q9NRC6 Q9NZL6 Q9UQM7 Q9Y4G8 Q9Y4H2	ACTN2 ANGPT1 AREG AREGB ARTN BSPECV BTC CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CD135 CDC25 CDHF12 CDHR16 CSF2 CSF2R CSF2RA CSF2RB CSF2RY DLG1 DLG2 DLG3 DLG4 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ERK1 ERK2 EVN FAK FAK1 FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 FRS3 FYN GDNF GDNFRA GDNFRB GFRA1 GFRA2 GFRA3 GFRA4 GGF GMCSF GNRP GRB1 GRF1 GRF2 GRIN1 GRIN2B GRIN2D GRP3 GluN2D HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRAS HRAS1 HRGA HST HST2 HSTF1 HSTF2 HUBSPECV HUSPECV HYPF IL15RB IL2 IL2RA IL2RB IL2RG IL3 IL3R IL3RA IL3RB IL5 IL5R IL5RA IL5RB INT2 IRS1 IRS2 JAK1 JAK1A JAK1B JAK2 JAK3 JTK2 KGF KIAA0003 KIAA0302 KIAA0313 KIAA0846 KIAA0959 KIAA0968 KIAA1232 KIAA1308 KIAA1365 KIAA1642 KIT KLB KS3 LAP1 LRRC7 MAPK1 MAPK3 MET MLN19 NCAM NCAM1 NDF NEAS NEFL NEU NF68 NFL NGL NMDAR1 NMDAR2B NMDAR2D NRAPGEP NRAS NRG1 NRG2 NRG3 NRG4 NRTN NSHC NTAK PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PDZGEF1 PEA15 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PRKM1 PRKM2 PRKM3 PSD95 PSPN PTC PTK2 PTPA PTPRA PTPRL2 RAB2L RALGDS RANBP9 RANBPM RAPGEF2 RASGEF1A RASGRF1 RASGRF2 RASGRP RASGRP1 RASGRP3 RASGRP4 RET RETL1 RETL2 RGF RGL RGL1 RGL2 RGL3 RHEPDGFRA SCA5 SCFR SCK SDGF SHC SHC1 SHC2 SHC3 SHCA SHCB SHCC SIS SMDF SOS1 SPTA SPTA1 SPTA2 SPTAN1 SPTB SPTB1 SPTB2 SPTBN1 SPTBN2 SPTBN3 SPTBN4 SPTBN5 STK1 TEK TGFA TIE2 TKF TRNR1 TRNR2 VMCM VMCM1
RAS processing	ADP-ribosylation factor-like protein 2 Acyl-protein thioesterase 1 Alpha/beta hydrolase domain-containing protein 17A Alpha/beta hydrolase domain-containing protein 17B Alpha/beta hydrolase domain-containing protein 17C Bcl-2-like protein 1 CAAX prenyl protease 2 Calmodulin-1 GTPase HRas GTPase KRas GTPase NRas Golgin subfamily A member 7 Palmitoyltransferase ZDHHC9 Protein farnesyltransferase subunit beta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Protein kinase C theta type Protein-S-isoprenylcysteine O-methyltransferase Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta Ubiquitin carboxyl-terminal hydrolase 17 cGMP-dependent protein kinase 2	O43924 O60725 O75608 P01111 P01112 P01116 P0DP23 P36404 P49354 P49356 Q04759 Q07817 Q13237 Q5VST6 Q6PCB6 Q6R6M4 Q7Z5G4 Q96GS6 Q9Y256 Q9Y397	ABHD17A ABHD17B ABHD17C APT1 ARL2 BCL2L BCL2L1 BCLX C19orf27 C9orf77 CALM CALM1 CAM CAM1 CXorf11 DUB3 FACE2 FAM108A1 FAM108B1 FAM108C1 FNTA FNTB GCP16 GOLGA7 HRAS HRAS1 ICMT KRAS KRAS2 LPL1 LYPLA1 NRAS PCCMT PDE6D PDED PRKCQ PRKCT PRKG2 PRKGR2 RASK2 RCE1 RCE1A RCE1B USP17 USP17H USP17I USP17J USP17K USP17L USP17L2 USP17M ZDHHC10 ZDHHC9 ZNF379 ZNF380
RAS signaling downstream of NF1 loss-of-function variants	GTPase HRas GTPase NRas Neurofibromin Sprouty-related, EVH1 domain-containing protein 1 Sprouty-related, EVH1 domain-containing protein 2 Sprouty-related, EVH1 domain-containing protein 3	P01111 P01112 P21359 Q2MJR0 Q7Z698 Q7Z699	EVE-3 HRAS HRAS1 NF1 NRAS SPRED1 SPRED2 SPRED3
RET signaling	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Artemin Docking protein 1 Docking protein 2 Docking protein 4 Docking protein 5 Docking protein 6 Fibroblast growth factor receptor substrate 2 GDNF family receptor alpha-1 GDNF family receptor alpha-2 GDNF family receptor alpha-3 GDNF family receptor alpha-4 GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Glial cell line-derived neurotrophic factor Growth factor receptor-bound protein 10 Growth factor receptor-bound protein 7 Insulin receptor substrate 2 Mitogen-activated protein kinase 7 Neurturin PDZ and LIM domain protein 7 Persephin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Protein kinase C alpha type Proto-oncogene tyrosine-protein kinase receptor Ret Rap1 GTPase-activating protein 1 SH3 and multiple ankyrin repeat domains protein 3 SHC-transforming protein 1 SHC-transforming protein 3 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	O00329 O00451 O00459 O60496 O60542 O60609 P07949 P17252 P17612 P19174 P22612 P22694 P27986 P29353 P39905 P42336 P42338 P47736 P56159 Q06124 Q07889 Q13164 Q13322 Q13480 Q14451 Q5T4W7 Q6PKX4 Q8TEW6 Q8WU20 Q92529 Q92569 Q99704 Q99748 Q9BYB0 Q9GZZ7 Q9NR12 Q9P104 Q9UQC2 Q9Y4H2	ARTN BMK1 C20orf180 CDHF12 CDHR16 DOK1 DOK2 DOK4 DOK5 DOK5L DOK6 ENIGMA ERK5 EVN FRS2 GAB1 GAB2 GDNF GDNFRA GDNFRB GFRA1 GFRA2 GFRA3 GFRA4 GRB1 GRB10 GRB7 GRBIR IRS2 KIAA0207 KIAA0474 KIAA0571 KIAA1650 MAPK7 NRTN NSHC PDLIM7 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PKACA PKCA PLC1 PLCG1 PRKACA PRKACB PRKACG PRKCA PRKM7 PROSAP2 PSAP2 PSPN PTC PTP2C PTPN11 RAP1GA1 RAP1GAP RET RETL1 RETL2 SHANK3 SHC SHC1 SHC3 SHCA SHCC SHPTP2 SOS1 TRNR1 TRNR2
RHO GTPases Activate Formins	Actin, cytoplasmic 1 Actin, cytoplasmic 2 Aurora kinase B B9 domain-containing protein 2 Baculoviral IAP repeat-containing protein 5 Borealin CAP-Gly domain-containing linker protein 1 CLIP-associating protein 1 CLIP-associating protein 2 Cell division control protein 42 homolog Cell division cycle protein 20 homolog Centromere protein C Centromere protein F Centromere protein H Centromere protein I Centromere protein K Centromere protein L Centromere protein M Centromere protein N Centromere protein O Centromere protein P Centromere protein Q Centromere protein R Centromere protein S Centromere protein T Centromere protein U Centromere-associated protein E Centromere/kinetochore protein zw10 homolog Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoplasmic dynein 1 light intermediate chain 1 Cytoplasmic dynein 1 light intermediate chain 2 Cytoskeleton-associated protein 5 DNA excision repair protein ERCC-6-like Disheveled-associated activator of morphogenesis 1 Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic E3 SUMO-protein ligase RanBP2 Ena/VASP-like protein Exportin-1 Formin-like protein 1 Formin-like protein 2 Formin-like protein 3 Histone H3-like centromeric protein A Inner centromere protein Integrin beta-1 Kinesin-like protein KIF18A Kinesin-like protein KIF2A Kinesin-like protein KIF2B Kinesin-like protein KIF2C Kinetochore protein NDC80 homolog Kinetochore protein Nuf2 Kinetochore protein Spc24 Kinetochore protein Spc25 Kinetochore scaffold 1 Kinetochore-associated protein 1 Kinetochore-associated protein DSN1 homolog Kinetochore-associated protein NSL1 homolog Microtubule-associated protein RP/EB family member 1 Mitotic checkpoint protein BUB3 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Mitotic checkpoint serine/threonine-protein kinase BUB1 Mitotic spindle assembly checkpoint protein MAD1 Mitotic spindle assembly checkpoint protein MAD2A Myocardin-related transcription factor A Nuclear distribution protein nudE homolog 1 Nuclear distribution protein nudE-like 1 Nuclear migration protein nudC Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup133 Nuclear pore complex protein Nup160 Nuclear pore complex protein Nup85 Nucleoporin Nup37 Nucleoporin Nup43 Platelet-activating factor acetylhydrolase IB subunit beta Polyamine-modulated factor 1 Profilin-1 Profilin-2 Protein ELYS Protein MIS12 homolog Protein RCC2 Protein SCAI Protein SEC13 homolog Protein Spindly Protein diaphanous homolog 1 Protein diaphanous homolog 3 Protein zwilch homolog Ran GTPase-activating protein 1 Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Rho-related GTP-binding protein RhoD SLIT-ROBO Rho GTPase-activating protein 2 Segment polarity protein dishevelled homolog DVL-1 Segment polarity protein dishevelled homolog DVL-2 Segment polarity protein dishevelled homolog DVL-3 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase TAO1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Serum response factor Shugoshin 1 Shugoshin 2 Small ribosomal subunit protein eS27 Spindle and kinetochore-associated protein 1 Spindle and kinetochore-associated protein 2 Transforming protein RhoA ZW10 interactor	O00139 O00212 O14576 O14640 O14641 O14777 O14980 O15392 O43237 O43264 O43683 O43684 O60566 O60610 O75044 O75122 O95229 O95466 P05556 P07737 P08134 P11831 P30153 P30154 P30622 P35080 P36873 P42677 P43034 P46060 P49450 P49454 P49792 P50748 P53350 P55735 P57740 P60709 P60953 P61586 P62714 P62745 P63000 P63167 P63261 P67775 Q02224 Q03188 Q12769 Q12834 Q13257 Q13352 Q13362 Q13409 Q14008 Q14204 Q14738 Q15172 Q15173 Q15691 Q16537 Q2NKX8 Q53HL2 Q562F6 Q5FBB7 Q6IPU0 Q6P1K2 Q71F23 Q7L2Z9 Q7L7X3 Q7Z460 Q8IVF7 Q8N0S6 Q8N2Z9 Q8N4N8 Q8N9R8 Q8NBT2 Q8NFH3 Q8NFH4 Q8NG31 Q8NI77 Q8WUM0 Q8WVK7 Q8WYP5 Q92674 Q92997 Q969V6 Q96BD8 Q96BT3 Q96EA4 Q96FJ2 Q96GD4 Q96H22 Q96IY1 Q96PY5 Q99661 Q9BPU9 Q9BS16 Q9BU64 Q9BW27 Q9BZD4 Q9GZM8 Q9H081 Q9H3R5 Q9H410 Q9H900 Q9HBM1 Q9NQS7 Q9NSP4 Q9NSV4 Q9NXR1 Q9P258 Q9UI08 Q9Y266 Q9Y4D1 Q9Y6D9 Q9Y6G9	ACTB ACTG ACTG1 AHCTF1 AIK2 AIM1 AIRK2 API4 APITD1 ARH12 ARH6 ARH9 ARHA ARHB ARHC ARHD ARHGAP34 ARK2 AURKB B9D2 BIRC5 BUB1 BUB1B BUB1L BUB3 BUBR1 C16orf56 C16orf60 C17orf1 C17orf1B C18orf24 C1orf155 C1orf48 C20orf172 C22orf18 C6orf139 C9orf126 CASC5 CCDC99 CDC20 CDC42 CDCA1 CDCA8 CENPA CENPC CENPC1 CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPR CENPS CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 CRM1 CYLN1 D3S1231E DAAM1 DHC1 DIAP1 DIAP3 DIAPH1 DIAPH3 DLC1 DLC2 DNCH1 DNCI1 DNCI2 DNCIC1 DNCIC2 DNCL DNCL1 DNCLC1 DNCLI1 DNCLI2 DNECL DSN1 DVL1 DVL2 DVL3 DYHC DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ELYS EOPA ERCC6L EVL FAAP16 FAM33A FHOD2 FHOD3 FMNL FMNL1 FMNL2 FMNL3 FNBP2 FNRB FRL1 FRL2 FSHPRH1 HDLC1 HEC HEC1 IAP4 ICEN19 ICEN22 ICEN24 ICEN32 ICEN33 ICEN35 ICEN36 ICEN37 ICEN39 ICEN7 INCENP ITGB1 ITGB3BP KIAA0044 KIAA0097 KIAA0166 KIAA0197 KIAA0208 KIAA0325 KIAA0456 KIAA0622 KIAA0627 KIAA0666 KIAA1361 KIAA1438 KIAA1470 KIAA1570 KIAA1835 KIAA1902 KIAA2014 KIF18A KIF2 KIF2A KIF2B KIF2C KLIP1 KNL1 KNS2 KNSL6 KNTC1 KNTC2 LIC2 LIS1 LRPR1 MAD1 MAD1L1 MAD2 MAD2L1 MAD3L MAL MAP3K16 MAPRE1 MARKK MAST1 MCM21R MDCR MDF2 MDS MHF1 MIS12 MIS13 MITAP1 MKL1 MKSR2 MLF1IP MPS1 MRTFA MSK12 NDC80 NDE1 NDEL1 NRIF3 NSL1 NUDC NUDE NUDEL NUF2 NUF2R NUP107 NUP120 NUP133 NUP160 NUP358 NUP37 NUP43 NUP75 NUP85 PAFAH1B1 PAFAHA PANE1 PBIP1 PCNT1 PESCRG3 PFN1 PFN2 PICH PLK PLK1 PMF1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RAC1 RANBP2 RANGAP1 RCC2 RHO12 RHOA RHOB RHOC RHOD RNB6 RPS27 RSN SCAI SD SEC13 SEC13A SEC13L1 SEC13R SGO1 SGO2 SGOL1 SGOL2 SKA1 SKA2 SPBC24 SPBC25 SPC24 SPC25 SPDL1 SRF SRGAP2 SRGAP2A SSK1 STK1 STK12 STK5 TAOK1 TC25 TD60 TMBS62 TXBP181 WBP3 XPO1 ZW10 ZWILCH ZWINT
RHO GTPases Activate NADPH Oxidases	Cytochrome b-245 heavy chain Cytochrome b-245 light chain Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 NADPH oxidase 1 NADPH oxidase 3 NADPH oxidase activator 1 NADPH oxidase organizer 1 Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Neutrophil cytosol factor 4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 Protein S100-A8 Protein S100-A9 Protein kinase C alpha type Protein kinase C beta type Protein kinase C delta type Protein kinase C zeta type Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2	P04839 P05109 P05771 P06702 P13498 P14598 P15153 P17252 P19878 P27361 P28482 P63000 Q05513 Q05655 Q13526 Q15080 Q15759 Q16539 Q86UR1 Q8NEB9 Q8NFA2 Q99570 Q9HBY0 Q9Y5S8	CAGA CAGB CFAG CSBP CSBP1 CSBP2 CSPB1 CYBA CYBB ERK1 ERK2 MAPK1 MAPK11 MAPK14 MAPK3 MOX1 MOX2 MRP14 MRP8 MXI2 NCF1 NCF2 NCF4 NOH1 NOX1 NOX2 NOX3 NOXA1 NOXA2 NOXO1 NOXO2 P41NOX P51NOX P67PHOX PIK3C3 PIK3R4 PIN1 PKC2 PKCA PKCB PKCD PRKACA PRKCA PRKCB PRKCB1 PRKCD PRKCZ PRKM1 PRKM11 PRKM2 PRKM3 RAC1 RAC2 S100A8 S100A9 SAPK2 SAPK2A SAPK2B SH3PXD1A SH3PXD4 SH3PXD5 TC25 VPS15 VPS34
RHO GTPases Activate ROCKs	Cofilin-1 LIM domain kinase 1 LIM domain kinase 2 Myosin light polypeptide 6 Myosin regulatory light chain 12B Myosin regulatory light polypeptide 9 Myosin-10 Myosin-11 Myosin-14 Myosin-9 Protein phosphatase 1 regulatory subunit 12A Protein phosphatase 1 regulatory subunit 12B Rho-associated protein kinase 1 Rho-associated protein kinase 2 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Serine/threonine-protein kinase PAK 1 Serine/threonine-protein phosphatase PP1-beta catalytic subunit Transforming protein RhoA	O14950 O14974 O60237 O75116 P08134 P23528 P24844 P35579 P35580 P35749 P53667 P53671 P60660 P61586 P62140 P62745 Q13153 Q13464 Q7Z406	ARH12 ARH6 ARH9 ARHA ARHB ARHC CFL CFL1 KIAA0619 KIAA0866 KIAA2034 LIMK LIMK1 LIMK2 MBS MLC2 MRLC1 MRLC2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLC2B MYPT1 MYPT2 MYRL2 PAK1 PPP1CB PPP1R12A PPP1R12B RHO12 RHOA RHOB RHOC ROCK1 ROCK2
RHO GTPases Activate Rhotekin and Rhophilins	Protein lin-7 homolog B Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Rhophilin-1 Rhophilin-2 Rhotekin Ropporin-1A Tax1-binding protein 3 Transforming protein RhoA	O14907 P08134 P61586 P62745 Q8IUC4 Q8TCX5 Q9BST9 Q9HAP6 Q9HAT0	ARH12 ARH6 ARH9 ARHA ARHB ARHC KIAA1929 LIN7B MALS2 RHO12 RHOA RHOB RHOC RHPN1 RHPN2 ROPN1 ROPN1A RTKN RTKN1 TAX1BP3 TIP1 VELI2
RHO GTPases Activate WASPs and WAVEs	Abl interactor 1 Abl interactor 2 Actin nucleation-promoting factor WAS Actin nucleation-promoting factor WASL Actin, cytoplasmic 1 Actin, cytoplasmic 2 Actin-binding protein WASF1 Actin-binding protein WASF2 Actin-binding protein WASF3 Actin-related protein 2/3 complex subunit 1A Actin-related protein 2/3 complex subunit 1B Actin-related protein 2/3 complex subunit 2 Actin-related protein 2/3 complex subunit 3 Actin-related protein 2/3 complex subunit 4 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2 Actin-related protein 3 BAR/IMD domain-containing adapter protein 2 Cell division control protein 42 homolog Cytoplasmic FMR1-interacting protein 1 Cytoplasmic FMR1-interacting protein 2 Focal adhesion kinase 1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 NCK-interacting protein with SH3 domain Nck-associated protein 1-like Nck-associated protein 1 Protein BRICK1 Ras-related C3 botulinum toxin substrate 1 SH2/SH3 adapter protein NCK1 Tyrosine-protein kinase ABL1 Tyrosine-protein kinase BTK WAS/WASL-interacting protein family member 1 WAS/WASL-interacting protein family member 2 WAS/WASL-interacting protein family member 3	A6NGB9 O00401 O15143 O15144 O15145 O15511 O43516 P00519 P16333 P27361 P28482 P42768 P55160 P59998 P60709 P60953 P61158 P61160 P63000 P63261 Q05397 Q06187 Q7L576 Q8IZP0 Q8TF74 Q8WUW1 Q92558 Q92747 Q96F07 Q9NYB9 Q9NZQ3 Q9UPY6 Q9UQB8 Q9Y2A7 Q9Y6W5	ABI1 ABI2 ABL ABL1 ACTB ACTG ACTG1 ACTR2 ACTR3 AF3P21 AGMX1 ARC16 ARC20 ARC21 ARC34 ARC41 ARGBPIA ARP2 ARP3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ATK BAIAP2 BPK BRK1 BTK C3orf10 CDC42 CR16 CYFIP1 CYFIP2 ERK1 ERK2 FAK FAK1 HEM1 HEM2 IMD2 JTK7 KIAA0068 KIAA0269 KIAA0587 KIAA0900 KIAA1168 MAPK1 MAPK3 NAP1 NCK NCK1 NCKAP1 NCKAP1L NCKIPSD PIR121 PRKM1 PRKM2 PRKM3 PTK2 RAC1 SCAR1 SCAR3 SOP2L SPIN90 SSH3BP1 TC25 WAS WASF1 WASF2 WASF3 WASL WASPIP WAVE1 WAVE2 WAVE3 WICH WIP WIPF1 WIPF2 WIPF3 WIRE
RHO GTPases activate CIT	Citron Rho-interacting kinase Cyclin-dependent kinase inhibitor 1B Disks large homolog 4 Kinesin-like protein KIF14 Myosin light polypeptide 6 Myosin regulatory light chain 12B Myosin regulatory light polypeptide 9 Myosin-10 Myosin-11 Myosin-14 Myosin-9 Protein phosphatase 1 regulatory subunit 12A Protein phosphatase 1 regulatory subunit 12B Protein regulator of cytokinesis 1 Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Serine/threonine-protein phosphatase PP1-beta catalytic subunit Transforming protein RhoA	O14578 O14950 O14974 O43663 O60237 P08134 P24844 P35579 P35580 P35749 P46527 P60660 P61586 P62140 P62745 P63000 P78352 Q15058 Q7Z406	ARH12 ARH6 ARH9 ARHA ARHB ARHC CDKN1B CIT CRIK DLG4 KIAA0042 KIAA0866 KIAA0949 KIAA2034 KIF14 KIP1 MBS MLC2 MRLC1 MRLC2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLC2B MYPT1 MYPT2 MYRL2 PPP1CB PPP1R12A PPP1R12B PRC1 PSD95 RAC1 RHO12 RHOA RHOB RHOC STK21 TC25 p27

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