GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **401 - 425** of **2090** in total

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Pathway Name	Protein Name	UniProt ID ▲	Gene Symbol	Organism	GlyTouCan ID
NOSTRIN mediated eNOS trafficking	Actin nucleation-promoting factor WASL Caveolin-1 Dynamin-2 Nitric oxide synthase 3 Nostrin	O00401 P29474 P50570 Q03135 Q8IVI9	CAV CAV1 DNM2 DYN2 NOS3 NOSTRIN WASL	Homo sapiens (human)
cGMP effects	Calcium-activated potassium channel subunit alpha-1 Calcium-activated potassium channel subunit beta-1 Calcium-activated potassium channel subunit beta-2 Calcium-activated potassium channel subunit beta-3 Calcium-activated potassium channel subunit beta-4 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Inositol 1,4,5-triphosphate receptor associated 1 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A cGMP-dependent 3',5'-cyclic phosphodiesterase cGMP-dependent protein kinase 2 cGMP-specific 3',5'-cyclic phosphodiesterase	O00408 O76074 O76083 P54750 Q01064 Q12791 Q13237 Q14643 Q16558 Q86W47 Q9HCR9 Q9NPA1 Q9Y233 Q9Y691 Q9Y6F6	INSP3R1 IRAG IRAG1 ITPR1 JAW1L KCNMA KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 KCNMBL MRVI1 PDE10A PDE11A PDE1A PDE1B PDE2A PDE5 PDE5A PDE9A PDES1B PRKG2 PRKGR2 SLO	Homo sapiens (human)
vRNP Assembly	Heat shock protein HSP 90-alpha Importin-5 Nucleoprotein Polymerase acidic protein Polymerase basic protein 2 RNA-directed RNA polymerase catalytic subunit	O00410 P03428 P03431 P03433 P03466 P07900	HSP90A HSP90AA1 HSPC1 HSPCA IPO5 KPNB3 NP PA PB1 PB2 RANBP5	Homo sapiens (human)
Transcriptional activation of mitochondrial biogenesis	3'-5' exoribonuclease HELZ2 5-aminolevulinate synthase, non-specific, mitochondrial ATP synthase subunit beta, mitochondrial Acetyl-coenzyme A synthetase, cytoplasmic CREB-binding protein CREB-regulated transcription coactivator 1 CREB-regulated transcription coactivator 2 CREB-regulated transcription coactivator 3 Calcium/calmodulin-dependent protein kinase type IV Calmodulin-1 Chromodomain-helicase-DNA-binding protein 9 Cyclic AMP-dependent transcription factor ATF-2 Cytochrome c DNA polymerase subunit gamma-2 DNA-directed RNA polymerase, mitochondrial Dimethyladenosine transferase 1, mitochondrial Dimethyladenosine transferase 2, mitochondrial F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 GA-binding protein alpha chain Glutamate dehydrogenase 1, mitochondrial Glutamate dehydrogenase 2, mitochondrial Histone deacetylase 3 Histone-arginine methyltransferase CARM1 Host cell factor 1 Isocitrate dehydrogenase [NADP], mitochondrial Mediator of RNA polymerase II transcription subunit 1 Myocyte-specific enhancer factor 2C Myocyte-specific enhancer factor 2D NAD-dependent protein deacetylase sirtuin-3, mitochondrial NAD-dependent protein deacylase sirtuin-5, mitochondrial NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 6 Nuclear receptor corepressor 1 Nuclear receptor subfamily 1 group D member 1 Nuclear respiratory factor 1 PGC-1 and ERR-induced regulator in muscle protein 1 Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Peroxisome proliferator-activated receptor gamma coactivator 1-beta Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 Retinoic acid receptor RXR-alpha SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Single-stranded DNA-binding protein, mitochondrial Steroid hormone receptor ERR1 Superoxide dismutase [Mn], mitochondrial Transcription factor A, mitochondrial Transcription termination factor 1, mitochondrial Trimethylguanosine synthase Twinkle mtDNA helicase	O00411 O15379 O60907 O75376 P00367 P04179 P06576 P0DP23 P11474 P13196 P15336 P19793 P20393 P48735 P49448 P51610 P99999 Q00059 Q04837 Q06413 Q06546 Q07869 Q14686 Q14814 Q15596 Q15648 Q15788 Q16566 Q16656 Q3L8U1 Q53ET0 Q5SV97 Q5VV67 Q6STE5 Q6UUV7 Q6UUV9 Q86X55 Q86YN6 Q8WVM0 Q92793 Q96RR1 Q96RS0 Q99551 Q9BYK8 Q9BZK7 Q9H5Q4 Q9NR19 Q9NTG7 Q9NXA8 Q9UBK2 Q9UHN1 Q9Y6E7	ACAS2 ACSS2 AIB3 ALAS1 ALAS3 ALASH ARC205 ATF2 ATP5B ATP5F1B ATPMB ATPSB BAF60C BHLHE74 BHLHE75 C10orf2 C1orf170 CALM CALM1 CAM CAM1 CAMK CAMK-GR CAMK4 CAMKIV CARM1 CBP CHD9 CREB2 CREBBP CREBP1 CRSP1 CRSP200 CRTC1 CRTC2 CRTC3 CYC CYCS DRIP205 DRIP230 E4TF1A EAR1 ERR1 ESRL1 ESRRA GABPA GLUD GLUD1 GLUD2 GLUDP1 HCA137 HCF1 HCFC1 HDAC3 HELZ2 HFC1 HREV IDH2 IRA1 KIAA0181 KIAA0308 KIAA0595 KIAA0616 KIAA1047 KIAA1769 KISH2 LEM6 MECT1 MED1 MEF2C MEF2D MTERF MTERF1 MTPOLB NCOA1 NCOA2 NCOA6 NCOA6IP NCOR1 NR1C1 NR1D1 NR2B1 NR3B1 NRF1 NS5ATP5 PBP PEO1 PERC PERM1 PGC1 PGC1A PGC1B PIMT POLG2 POLRMT PPAR PPARA PPARBP PPARGBP PPARGC1 PPARGC1A PPARGC1B PPRC1 PRIC285 PRIC320 PRMT4 RAP250 RB18A RXRA SIR2L3 SIR2L4 SIR2L5 SIRT3 SIRT4 SIRT5 SMARCD3 SOD2 SRC1 SRC2 SSBP SSBP1 TBL1 TBL1X TBL1XR1 TBLR1 TCF6 TCF6L2 TFAM TFB1M TFB2M TGS1 THRAL TIF2 TORC1 TORC2 TORC3 TRAP220 TRBP TRIP2 TWNK WAMTP1	Homo sapiens (human)
Mitochondrial transcription initiation	DNA-directed RNA polymerase, mitochondrial Dimethyladenosine transferase 2, mitochondrial Transcription factor A, mitochondrial	O00411 Q00059 Q9H5Q4	NS5ATP5 POLRMT TCF6 TCF6L2 TFAM TFB2M	Homo sapiens (human)
mTORC1-mediated signalling	14-3-3 protein beta/alpha Eukaryotic elongation factor 2 kinase Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4B Eukaryotic translation initiation factor 4E-binding protein 1 Eukaryotic translation initiation factor 4E GTP-binding protein Rheb Neutral amino acid transporter 9 Peptidyl-prolyl cis-trans isomerase FKBP1A Proline-rich AKT1 substrate 1 Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Ribosomal protein S6 kinase beta-1 Serine/threonine-protein kinase mTOR Small ribosomal subunit protein eS6 Target of rapamycin complex subunit LST8	O00418 O43504 P06730 P23443 P23588 P31946 P42345 P62753 P62942 Q04637 Q0VGL1 Q13541 Q15382 Q5VZM2 Q6IAA8 Q7L523 Q8N122 Q8NBW4 Q96B36 Q9BVC4 Q9HB90 Q9NQL2 Q9UHA4 Q9Y2Q5	AKT1S1 C11orf59 C7orf59 EEF2K EIF4B EIF4E EIF4EBP1 EIF4EL1 EIF4F EIF4G EIF4G1 EIF4GI FKBP1 FKBP12 FKBP1A FRAP FRAP1 FRAP2 GBL HBXIP KIAA1303 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MTOR PDRO PRAS40 RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPS6 RPS6KB1 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 STK14A URLC11 XIP YWHAB	Homo sapiens (human)
Chemokine receptors bind chemokines	Atypical chemokine receptor 2 Atypical chemokine receptor 3 Atypical chemokine receptor 4 C-C chemokine receptor type 10 C-C chemokine receptor type 1 C-C chemokine receptor type 2 C-C chemokine receptor type 3 C-C chemokine receptor type 4 C-C chemokine receptor type 5 C-C chemokine receptor type 6 C-C chemokine receptor type 7 C-C chemokine receptor type 8 C-C chemokine receptor type 9 C-C chemokine receptor-like 2 C-C motif chemokine 13 C-C motif chemokine 16 C-C motif chemokine 17 C-C motif chemokine 19 C-C motif chemokine 1 C-C motif chemokine 20 C-C motif chemokine 21 C-C motif chemokine 22 C-C motif chemokine 25 C-C motif chemokine 27 C-C motif chemokine 28 C-C motif chemokine 2 C-C motif chemokine 3-like 1 C-C motif chemokine 3 C-C motif chemokine 4 C-C motif chemokine 5 C-C motif chemokine 7 C-X-C chemokine receptor type 1 C-X-C chemokine receptor type 2 C-X-C chemokine receptor type 3 C-X-C chemokine receptor type 4 C-X-C chemokine receptor type 5 C-X-C chemokine receptor type 6 C-X-C motif chemokine 10 C-X-C motif chemokine 11 C-X-C motif chemokine 13 C-X-C motif chemokine 16 C-X-C motif chemokine 2 C-X-C motif chemokine 3 C-X-C motif chemokine 5 C-X-C motif chemokine 6 C-X-C motif chemokine 9 CX3C chemokine receptor 1 Chemokine XC receptor 1 Cytokine SCM-1 beta Eotaxin Fractalkine Growth-regulated alpha protein Interleukin-8 Lymphotactin Platelet basic protein Platelet factor 4 Stromal cell-derived factor 1	O00421 O00574 O00585 O00590 O00626 O14625 O15444 O15467 O43927 P02775 P02776 P02778 P09341 P10145 P10147 P13236 P13500 P13501 P16619 P19875 P19876 P22362 P25024 P25025 P25106 P32246 P32248 P32302 P41597 P42830 P46092 P46094 P47992 P48061 P49238 P49682 P51671 P51677 P51679 P51681 P51684 P51685 P51686 P61073 P78423 P78556 P80098 P80162 Q07325 Q92583 Q99616 Q99731 Q9H2A7 Q9NPB9 Q9NRJ3 Q9UBD3 Q9Y4X3	ACKR2 ACKR3 ACKR4 BCA1 BLC BLR1 BONZO CCBP2 CCL1 CCL11 CCL13 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCR1 CCR10 CCR11 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL1 CCRL2 CCXCR1 CKRL1 CKRL3 CKRX CMK CMKAR1 CMKBR1 CMKBR2 CMKBR3 CMKBR4 CMKBR5 CMKBR6 CMKBR7 CMKBR8 CMKBR9 CMKBRL1 CMKBRL2 CMKOR1 CMKR1 CRAM CTAP3 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7 D17S136E D17S1718 D6 EBI1 ELC ENA78 EVI1 FKN G0S19-1 G0S19-2 GCP2 GPR13 GPR159 GPR2 GPR28 GPR29 GPR5 GPR9 GRO GRO1 GRO2 GRO3 GROA GROB GROG HCR IL8 IL8RA IL8RB ILC ILINCK INP10 ITAC LAG1 LARC LTN MCP1 MCP3 MCP4 MDC MDR15 MGSA MIG MIP1A MIP1B MIP2A MIP3A MIP3B NCC1 NCC4 NTT PF4 PPBP RDC1 SCYA1 SCYA11 SCYA13 SCYA16 SCYA17 SCYA19 SCYA2 SCYA20 SCYA21 SCYA22 SCYA25 SCYA27 SCYA28 SCYA3 SCYA3L1 SCYA4 SCYA5 SCYA6 SCYA7 SCYAR1 SCYB1 SCYB10 SCYB11 SCYB13 SCYB16 SCYB2 SCYB3 SCYB4 SCYB5 SCYB6 SCYB7 SCYB9 SCYB9B SCYC1 SCYC2 SCYD1 SDF1 SDF1A SDF1B SRPSOX STRL22 STRL33 TARC TECK TGB1 THBGB1 TYMSTR VSHK1 XCL1 XCL2 XCR1	Homo sapiens (human)
pre-mRNA splicing	116 kDa U5 small nuclear ribonucleoprotein component 17S U2 SnRNP complex component HTATSF1 ATP-dependent RNA helicase A ATP-dependent RNA helicase DDX42 ATP-dependent RNA helicase DHX15 ATP-dependent RNA helicase DHX8 Apoptotic chromatin condensation inducer in the nucleus BUD13 homolog Beta-catenin-like protein 1 CWF19-like protein 2 Calcium homeostasis endoplasmic reticulum protein Cell division cycle 5-like protein Cell division cycle and apoptosis regulator protein 1 Coiled-coil domain-containing protein 12 Crooked neck-like protein 1 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 DnaJ homolog subfamily C member 8 E3 ubiquitin-protein ligase RNF113A Eukaryotic initiation factor 4A-III Exosome RNA helicase MTR4 G patch domain-containing protein 1 G-patch domain and KOW motifs-containing protein General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 Heat shock cognate 71 kDa protein Heterogeneous nuclear ribonucleoprotein A1 Heterogeneous nuclear ribonucleoprotein A3 Heterogeneous nuclear ribonucleoprotein D0 Heterogeneous nuclear ribonucleoprotein F Heterogeneous nuclear ribonucleoprotein H2 Heterogeneous nuclear ribonucleoprotein H Heterogeneous nuclear ribonucleoprotein K Heterogeneous nuclear ribonucleoprotein L Heterogeneous nuclear ribonucleoprotein M Heterogeneous nuclear ribonucleoprotein R Heterogeneous nuclear ribonucleoprotein U Heterogeneous nuclear ribonucleoproteins A2/B1 Heterogeneous nuclear ribonucleoproteins C1/C2 Histone deacetylase complex subunit SAP18 Intron Large complex component GCFC2 Leukocyte receptor cluster member 1 Luc7-like protein 3 Microfibrillar-associated protein 1 NF-kappa-B-activating protein NHP2-like protein 1 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Nuclear inhibitor of protein phosphatase 1 Nuclear speckle splicing regulatory protein 1 PHD finger-like domain-containing protein 5A PRKR-interacting protein 1 Peptidyl-prolyl cis-trans isomerase E Peptidyl-prolyl cis-trans isomerase G Peptidyl-prolyl cis-trans isomerase H Peptidyl-prolyl cis-trans isomerase-like 1 Peptidyl-prolyl cis-trans isomerase-like 3 Peptidyl-prolyl cis-trans isomerase-like 4 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 Pinin Pleiotropic regulator 1 Poly(U)-binding-splicing factor PUF60 Poly(rC)-binding protein 1 Poly(rC)-binding protein 2 Polyglutamine-binding protein 1 Polypyrimidine tract-binding protein 1 Pre-mRNA-processing factor 17 Pre-mRNA-processing factor 19 Pre-mRNA-processing factor 40 homolog A Pre-mRNA-processing factor 6 Pre-mRNA-processing-splicing factor 8 Pre-mRNA-splicing factor 18 Pre-mRNA-splicing factor 38A Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 Pre-mRNA-splicing factor CWC22 homolog Pre-mRNA-splicing factor CWC25 homolog Pre-mRNA-splicing factor ISY1 homolog Pre-mRNA-splicing factor RBM22 Pre-mRNA-splicing factor SLU7 Pre-mRNA-splicing factor SPF27 Pre-mRNA-splicing factor SYF1 Pre-mRNA-splicing factor SYF2 Probable ATP-dependent RNA helicase DDX23 Probable ATP-dependent RNA helicase DDX41 Probable ATP-dependent RNA helicase DDX46 Probable ATP-dependent RNA helicase DDX5 Probable ATP-dependent RNA helicase DHX35 Proline-rich protein PRCC Protein BUD31 homolog Protein CASC3 Protein FAM32A Protein FAM50A Protein Red Protein mago nashi homolog 2 Protein mago nashi homolog RING-type E3 ubiquitin-protein ligase PPIL2 RNA helicase aquarius RNA-binding motif protein, X chromosome RNA-binding motif protein, X-linked 2 RNA-binding protein 10 RNA-binding protein 25 RNA-binding protein 39 RNA-binding protein 42 RNA-binding protein 5 RNA-binding protein 7 RNA-binding protein 8A RNA-binding protein FUS RNA-binding protein with serine-rich domain 1 Regulator of nonsense transcripts 3B SNW domain-containing protein 1 STING ER exit protein SURP and G-patch domain-containing protein 1 Serine/arginine repetitive matrix protein 1 Serine/arginine repetitive matrix protein 2 Serine/arginine-rich splicing factor 10 Serine/arginine-rich splicing factor 11 Serine/arginine-rich splicing factor 12 Serine/arginine-rich splicing factor 1 Serine/arginine-rich splicing factor 2 Serine/arginine-rich splicing factor 3 Serine/arginine-rich splicing factor 4 Serine/arginine-rich splicing factor 5 Serine/arginine-rich splicing factor 6 Serine/arginine-rich splicing factor 7 Serine/arginine-rich splicing factor 8 Serine/arginine-rich splicing factor 9 Serine/threonine-protein kinase PRP4 homolog Serrate RNA effector molecule homolog Smad nuclear-interacting protein 1 Small nuclear ribonucleoprotein E Small nuclear ribonucleoprotein F Small nuclear ribonucleoprotein G Small nuclear ribonucleoprotein Sm D1 Small nuclear ribonucleoprotein Sm D2 Small nuclear ribonucleoprotein Sm D3 Small nuclear ribonucleoprotein-associated protein N Small nuclear ribonucleoprotein-associated proteins B and B' Spliceosome RNA helicase DDX39B Spliceosome-associated protein CWC15 homolog Spliceosome-associated protein CWC27 homolog Splicing factor 1 Splicing factor 3A subunit 1 Splicing factor 3A subunit 2 Splicing factor 3A subunit 3 Splicing factor 3B subunit 1 Splicing factor 3B subunit 2 Splicing factor 3B subunit 3 Splicing factor 3B subunit 4 Splicing factor 3B subunit 5 Splicing factor 3B subunit 6 Splicing factor 45 Splicing factor C9orf78 Splicing factor Cactin Splicing factor U2AF 26 kDa subunit Splicing factor U2AF 35 kDa subunit Splicing factor U2AF 65 kDa subunit Splicing factor YJU2 Splicing regulator SDE2 Survival of motor neuron-related-splicing factor 30 THO complex subunit 4 Thioredoxin-like protein 4A Transcription elongation regulator 1 Transformer-2 protein homolog beta Tuftelin-interacting protein 11 U1 small nuclear ribonucleoprotein 70 kDa U1 small nuclear ribonucleoprotein A U1 small nuclear ribonucleoprotein C U2 small nuclear ribonucleoprotein A' U2 small nuclear ribonucleoprotein B'' U2 snRNP-associated SURP motif-containing protein U4/U6 small nuclear ribonucleoprotein Prp31 U4/U6 small nuclear ribonucleoprotein Prp3 U4/U6 small nuclear ribonucleoprotein Prp4 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein U4/U6.U5 tri-snRNP-associated protein 1 U5 small nuclear ribonucleoprotein 200 kDa helicase U5 small nuclear ribonucleoprotein 40 kDa protein U6 snRNA-associated Sm-like protein LSm2 U6 snRNA-associated Sm-like protein LSm3 U6 snRNA-associated Sm-like protein LSm4 U6 snRNA-associated Sm-like protein LSm5 U6 snRNA-associated Sm-like protein LSm6 U6 snRNA-associated Sm-like protein LSm7 U6 snRNA-associated Sm-like protein LSm8 Ubiquitin carboxyl-terminal hydrolase 39 Ubiquitin-like protein 5 WD repeat-containing protein 70 WD40 repeat-containing protein SMU1 WW domain-binding protein 11 WW domain-binding protein 4 Y-box-binding protein 1 Zinc finger matrin-type protein 2 Zinc finger protein 830	O00422 O14776 O15042 O15234 O15514 O15541 O43143 O43172 O43290 O43390 O43395 O43447 O43660 O43719 O60231 O60306 O60508 O60828 O75400 O75494 O75533 O75554 O75643 O75934 O75937 O75940 O94906 O95232 O95391 O95777 O95926 P07910 P08579 P08621 P09012 P09234 P09651 P09661 P11142 P13984 P14678 P14866 P16383 P17844 P19387 P19388 P22626 P24928 P26368 P26599 P30876 P31943 P35269 P35637 P36954 P38159 P38919 P41223 P42285 P49756 P51991 P52272 P52298 P52434 P52435 P52597 P52756 P53803 P55081 P55769 P55795 P61218 P61326 P61978 P62304 P62306 P62308 P62310 P62312 P62314 P62316 P62318 P62487 P62875 P62995 P63162 P67809 P83876 P84103 P98175 Q00839 Q01081 Q01130 Q05519 Q07955 Q08170 Q08211 Q09161 Q12874 Q12972 Q13123 Q13242 Q13243 Q13247 Q13356 Q13427 Q13435 Q13523 Q13573 Q13838 Q14103 Q14320 Q14498 Q14562 Q15029 Q15287 Q15365 Q15366 Q15393 Q15427 Q15428 Q15459 Q15637 Q16629 Q2TAY7 Q2TBE0 Q53GS9 Q6IQ49 Q6P2Q9 Q6UX04 Q7L014 Q7RTV0 Q86V81 Q86XP3 Q8IWX8 Q8IWZ8 Q8IX12 Q8IYB3 Q8N5F7 Q8NAV1 Q8TAD8 Q8WU68 Q8WUA2 Q8WUD4 Q8WUQ7 Q8WVK2 Q8WWY3 Q8WXF0 Q8WYA6 Q92620 Q92733 Q92917 Q96A72 Q96BP3 Q96BZ8 Q96DI7 Q96I25 Q96NB3 Q96NC0 Q99459 Q99633 Q9BRD0 Q9BRL6 Q9BRR8 Q9BTD8 Q9BUQ8 Q9BW85 Q9BWJ5 Q9BXP5 Q9BZI7 Q9BZJ0 Q9BZL1 Q9H0G5 Q9H2H8 Q9H307 Q9H5V9 Q9H5Z1 Q9H875 Q9HCG8 Q9HCS7 Q9NW64 Q9NW82 Q9NXE8 Q9NZ63 Q9P013 Q9UBB9 Q9UHX1 Q9UJV9 Q9UK45 Q9UKV3 Q9ULR0 Q9UMS4 Q9UNP9 Q9UQ35 Q9Y2W2 Q9Y333 Q9Y388 Q9Y3B4 Q9Y3C6 Q9Y421 Q9Y4Y9 Q9Y4Z0 Q9Y580 Q9Y5S9	ABS ACIN1 ACINUS ALY ALYREF AQR ARD1 ARS2 ASCC3L1 ASF ASR2 AUF1 BAT1 BCAS2 BEF BRR2 BUD13 BUD31 C11orf5 C19orf29 C1orf199 C1orf55 C20orf14 C20orf15 C20orf33 C2orf3 C6orf28 C9orf78 CA150 CACTIN CARP1 CASC3 CBP20 CBP80 CBPIN CCAR1 CCDC12 CCDC16 CCDC49 CCDC55 CCDC94 CDC40 CDC5L CHERP COD CREAP1 CRN CRNKL1 CROP CTNNBL1 CWC15 CWC22 CWC25 CWC27 CWF19L2 CXorf56 CYP20 CYP33 CYPH CYPL1 DAM1 DAN26 DBP1 DBP2 DDX15 DDX16 DDX23 DDX35 DDX38 DDX39B DDX41 DDX42 DDX46 DDX48 DDX5 DDX8 DDX9 DHX15 DHX16 DHX35 DHX38 DHX8 DHX9 DIM1 DIS DNAJC8 DOB1 DRS DXS8237E DXS9928E ECGP EDG2 EFTUD2 EHB3 EIF4A3 FAM32A FAM50A FBP11 FBP21 FIR FLAF1 FNBP21 FNBP3 FTP3 FUS FUSIP1 FUSIP2 G17P1 G7B GCF GCFC2 GCIPIP GPATC1 GPATC5 GPATC9 GPATCH1 GPATCH5 GPATCH9 GPKOW GTF2F1 GTF2F2 HCA59 HCC1 HCERN3 HCNP HELIC2 HELR HIP10 HLR1 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPM HNRNPR HNRNPU HNRPA1 HNRPA2B1 HNRPA3 HNRPC HNRPD HNRPF HNRPG HNRPH HNRPH1 HNRPH2 HNRPK HNRPL HNRPM HNRPR HNRPU HPRP18 HPRP3 HRS HSC70 HSP73 HSPA10 HSPA8 HTATSF1 HXC26 HYPA IK ISY1 KIAA0017 KIAA0031 KIAA0052 KIAA0073 KIAA0111 KIAA0122 KIAA0224 KIAA0324 KIAA0332 KIAA0432 KIAA0536 KIAA0560 KIAA0577 KIAA0670 KIAA0788 KIAA0801 KIAA1160 KIAA1177 KIAA1604 LDC2 LENG1 LKP LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 LUC7L3 MAGOH MAGOH2 MAGOHA MAGOHB MEMA MFAP1 MLN51 MTR4 MTREX NAGR1 NCBP NCBP1 NCBP2 NCM NDH2 NHP2L1 NIPP1 NKAP NMP200 NPW38 NPWBP NSEP1 NSRP1 NSRP70 O48 OTAG12 PBSCF PBSCG PCBP1 PCBP2 PCDC5RP PHF5A PLRG1 PNN POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF PPIE PPIG PPIH PPIL1 PPIL2 PPIL3 PPIL4 PPP1R8 PPWD1 PQBP1 PRCC PRKRIP1 PRP16 PRP17 PRP19 PRP2 PRP3 PRP31 PRP4 PRP4B PRP4H PRP4K PRP8BP PRPC8 PRPF17 PRPF18 PRPF19 PRPF3 PRPF31 PRPF38A PRPF4 PRPF40A PRPF4K PRPF6 PRPF8 PTB PTBP1 PUF60 RAP30 RAP74 RBM10 RBM17 RBM22 RBM25 RBM39 RBM42 RBM5 RBM7 RBM8 RBM8A RBMX RBMX2 RBMXP1 RED RENT3B RER RNF113 RNF113A RNPC2 RNPC7 RNPS1 RNPU1Z ROBPI RPB7 RPU1 SAFA SAP114 SAP130 SAP14 SAP145 SAP155 SAP18 SAP49 SAP61 SAP62 SART1 SCAF6 SDCCAG10 SDE2 SF1 SF2 SF2P33 SF3A1 SF3A2 SF3A3 SF3B1 SF3B10 SF3B14 SF3B14A SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SF4 SFP38 SFRS1 SFRS10 SFRS11 SFRS13A SFRS13B SFRS19 SFRS2 SFRS2B SFRS3 SFRS4 SFRS5 SFRS6 SFRS7 SFRS9 SIAHBP1 SIPP1 SKIIP SKIP SKIV2L2 SLU7 SMN SMNDC1 SMNR SMU1 SNEV SNIP1 SNP70 SNRNP200 SNRNP27 SNRNP40 SNRNP70 SNRP116 SNRP70 SNRPA SNRPA1 SNRPB SNRPB1 SNRPB2 SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNRPN SNU13 SNW1 SPF30 SPF31 SPF45 SR140 SRL300 SRM160 SRM300 SRP20 SRP30C SRP40 SRP46 SRP55 SRP75 SRRM1 SRRM2 SRRP35 SRRT SRSF1 SRSF10 SRSF11 SRSF12 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SRSF9 STEEP1 STIP SUGP1 SYF1 SYF2 T54 TAF2S TASR TCERG1 TCF9 TFIP11 THOC4 TLS TPRC TRA2B TXNL4 TXNL4A U1AP1 U21.1 U2AF1 U2AF1-RS3 U2AF1L3 U2AF1L4 U2AF2 U2AF35 U2AF65 U2AFBP U2SURP UAP56 UBL5 UPF3B UPF3X USP39 WBP11 WBP4 WDR57 WDR70 XAB2 XAP5 YB1 YBX1 YJU2 ZC3H16 ZFM1 ZMAT2 ZNF162 ZNF183 ZNF830	Homo sapiens (human)
NoRC negatively regulates rRNA expression	AT-rich interactive domain-containing protein 4B Bromodomain adjacent to zinc finger domain protein 2A CDK-activating kinase assembly factor MAT1 Cyclin-H Cyclin-dependent kinase 7 DNA (cytosine-5)-methyltransferase 1 DNA (cytosine-5)-methyltransferase 3B DNA-directed RNA polymerase I subunit RPA12 DNA-directed RNA polymerase I subunit RPA1 DNA-directed RNA polymerase I subunit RPA2 DNA-directed RNA polymerase I subunit RPA34 DNA-directed RNA polymerase I subunit RPA43 DNA-directed RNA polymerase I subunit RPA49 DNA-directed RNA polymerases I and III subunit RPAC1 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone deacetylase 1 Histone deacetylase 2 Histone deacetylase complex subunit SAP130 Histone deacetylase complex subunit SAP18 Histone deacetylase complex subunit SAP30 Histone deacetylase complex subunit SAP30L Methyl-CpG-binding domain protein 2 Nucleolar transcription factor 1 Paired amphipathic helix protein Sin3a Paired amphipathic helix protein Sin3b Protein POLR1D, isoform 2 SAP30-binding protein SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Sin3 histone deacetylase corepressor complex component SDS3 TATA box-binding protein-associated factor RNA polymerase I subunit A TATA box-binding protein-associated factor RNA polymerase I subunit B TATA box-binding protein-associated factor RNA polymerase I subunit C TATA box-binding protein-associated factor RNA polymerase I subunit D TATA-box-binding protein Transcription termination factor 1	O00422 O15160 O15446 O60264 O60814 O75182 O75446 O95602 P04908 P06899 P0C5Y9 P0DPB5 P16104 P17480 P18074 P19388 P19447 P20226 P20671 P23527 P26358 P32780 P33778 P50613 P51946 P51948 P52434 P53803 P57053 P58876 P61218 P62805 P62807 P62875 P68431 P84243 Q13547 Q13888 Q13889 Q15361 Q15572 Q15573 Q16777 Q16778 Q3B726 Q4LE39 Q53T94 Q6FI13 Q6ZYL4 Q71DI3 Q71UI9 Q8N257 Q92759 Q92769 Q93077 Q93079 Q96A08 Q96ST3 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9GZS1 Q9H0E3 Q9H5J8 Q9H7L9 Q9H9Y6 Q9HAJ7 Q9P1U0 Q9UBB5 Q9UBC3 Q9UHR5 Q9UIF9	AIM ARID4B ASE1 BAZ2A BRCAA1 BTF2 BTF2P44 C6orf175 CAK CAK1 CAP35 CAST CCNH CD3EAP CDK7 CDKN7 CXXC9 DNMT DNMT1 DNMT3B ERCC2 ERCC3 GTF2D1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HCNGP HDAC1 HDAC2 HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 HTRG HTRP JOSD3 KIAA0314 KIAA0700 MAT1 MBD2 MNAT1 MO15 NS4ATP2 PAF49 PAF53 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L POLRF PRAF1 RBBP1L1 RBP1L1 RNF66 RPA12 RPD3L1 SAP130 SAP18 SAP180 SAP30 SAP30BP SAP30L SAP45 SDS3 SIN3A SIN3B SMARCA5 SNF2H STK1 SUDS3 TAF1A TAF1B TAF1C TAF1D TBP TF2D TFIID TIP5 TSH2B TTDA TTF1 TWISTNB UBF UBF1 UBTF WCRF135 XPB XPBC XPD XPDC ZNRD1	Homo sapiens (human)
HDACs deacetylate histones	AT-rich interactive domain-containing protein 4A AT-rich interactive domain-containing protein 4B Breast cancer metastasis-suppressor 1 Chromodomain-helicase-DNA-binding protein 3 Chromodomain-helicase-DNA-binding protein 4 F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 G protein pathway suppressor 2 Histone H2A type 1-A Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-H Histone H2A type 1-J Histone H2A type 1 Histone H2A type 2-A Histone H2A type 2-B Histone H2A type 2-C Histone H2A type 3 Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 2-F Histone H2B type 3-B Histone H3.1 Histone H3.2 Histone H4 Histone deacetylase 1 Histone deacetylase 2 Histone deacetylase 3 Histone deacetylase 8 Histone deacetylase complex subunit SAP18 Histone deacetylase complex subunit SAP30 Histone deacetylase complex subunit SAP30L Histone-binding protein RBBP4 Histone-binding protein RBBP7 Lysine-specific histone demethylase 1A Metastasis-associated protein MTA1 Metastasis-associated protein MTA2 Metastasis-associated protein MTA3 Methyl-CpG-binding domain protein 3 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 PHD finger protein 21A Polyamine deacetylase HDAC10 RE1-silencing transcription factor REST corepressor 1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related Sin3 histone deacetylase corepressor complex component SDS3 Transcriptional repressor p66-alpha Transcriptional repressor p66-beta	O00422 O15379 O60341 O60814 O60907 O75376 O75446 O94776 O95983 P04908 P06899 P0C0S8 P20671 P23527 P29374 P33778 P58876 P62805 P62807 P68431 Q09028 Q12873 Q13127 Q13227 Q13330 Q13547 Q14839 Q16576 Q16777 Q16778 Q4LE39 Q5QNW6 Q6FI13 Q71DI3 Q7L7L0 Q86YP4 Q8IUE6 Q8N257 Q8WXI9 Q92769 Q93077 Q93079 Q969S8 Q96A08 Q96BD5 Q96KK5 Q96QV6 Q99877 Q99878 Q99879 Q99880 Q9BTC8 Q9BY41 Q9BZK7 Q9H7L9 Q9HAJ7 Q9HCU9 Q9P0W2 Q9UKL0 Q9Y618	AOF2 ARID4A ARID4B BHC80 BRAF35 BRCAA1 BRMS1 CHD3 CHD4 CTG26 GATAD2A GATAD2B GPS2 H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFC H2AFD H2AFE H2AFG H2AFI H2AFL H2AFM H2AFN H2AFO H2AFP H2AFQ H2AFR H2AW H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC18 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFT H2BU1 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HDAC1 HDAC10 HDAC2 HDAC3 HDAC8 HDACL1 HIRIP1 HIRIP2 HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AG HIST1H2AH HIST1H2AI HIST1H2AJ HIST1H2AK HIST1H2AL HIST1H2AM HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AB HIST2H2AC HIST2H2BE HIST2H2BF HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2A HIST3H2BB HIST4H4 HMG20B HMGX2 HMGXB2 IRA1 KDM1 KDM1A KIAA0071 KIAA0601 KIAA1047 KIAA1150 KIAA1266 KIAA1696 LSD1 MBD3 MTA1 MTA1L1 MTA2 MTA3 NCOR1 NCOR2 NRSF NS4ATP2 PHF21A PID RBAP46 RBAP48 RBBP1 RBBP1L1 RBBP4 RBBP7 RBP1 RBP1L1 RCOR RCOR1 REST RPD3L1 SAP18 SAP180 SAP30 SAP30L SAP45 SDS3 SMARCE1R SUDS3 TBL1 TBL1X TBL1XR1 TBLR1 TSH2B XBR	Homo sapiens (human)
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	Insulin-like growth factor 2 mRNA-binding protein 1 Insulin-like growth factor 2 mRNA-binding protein 2 Insulin-like growth factor 2 mRNA-binding protein 3	O00425 Q9NZI8 Q9Y6M1	CRDBP IGF2BP1 IGF2BP2 IGF2BP3 IMP2 IMP3 KOC1 VICKZ1 VICKZ2 VICKZ3 ZBP1	Homo sapiens (human)
Apoptotic execution phase	B-cell receptor-associated protein 31 Caspase-8 Dynamin-1-like protein Serine/threonine-protein kinase 24	O00429 P51572 Q14790 Q9Y6E0	BAP31 BCAP31 CASP8 DLP1 DNM1L DRP1 DXS1357E MCH5 MST3 STK24 STK3	Homo sapiens (human)
Synthesis of PIPs at the early endosome membrane	1-phosphatidylinositol 3-phosphate 5-kinase Inositol polyphosphate 4-phosphatase type II Inositol polyphosphate-4-phosphatase type I A Myotubularin-related protein 10 Myotubularin-related protein 12 Myotubularin-related protein 2 Myotubularin-related protein 4 Myotubularin Phosphatidylinositide phosphatase SAC2 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 4-kinase type 2-alpha Phosphatidylinositol 4-kinase type 2-beta Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphoinositide 3-kinase regulatory subunit 4 Polyphosphoinositide phosphatase Protein VAC14 homolog	O00443 O15327 Q08AM6 Q13496 Q13614 Q8NEB9 Q8TCG2 Q92562 Q96PE3 Q99570 Q9BTU6 Q9C0I1 Q9NXD2 Q9NYA4 Q9Y2H2 Q9Y2I7	CG2 FIG4 INPP4A INPP4B INPP5F KIAA0274 KIAA0647 KIAA0966 KIAA0981 KIAA1073 KIAA1682 MTM1 MTMR10 MTMR12 MTMR2 MTMR4 PI4K2A PI4K2B PIK3C2A PIK3C3 PIK3R4 PIKFYVE PIP3AP PIP5K3 SAC2 SAC3 TAX1BP2 TRX VAC14 VPS15 VPS34 ZFYVE11	Homo sapiens (human)
Synthesis of PIPs at the Golgi membrane	1-phosphatidylinositol 3-phosphate 5-kinase ADP-ribosylation factor 1 ADP-ribosylation factor 3 Inositol polyphosphate 5-phosphatase OCRL Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 4-kinase alpha Phosphatidylinositol 4-kinase beta Phosphatidylinositol 4-kinase type 2-alpha Phosphatidylinositol 4-kinase type 2-beta Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphatidylinositol polyphosphate 5-phosphatase type IV Phosphatidylinositol-3-phosphatase SAC1 Phosphoinositide 3-kinase regulatory subunit 4 Polyphosphoinositide phosphatase Protein VAC14 homolog Putative tyrosine-protein phosphatase TPTE	O00443 O75747 P42356 P56180 P61204 P84077 Q01968 Q08AM6 Q6XPS3 Q8NEB9 Q8TCG2 Q92562 Q99570 Q9BTU6 Q9NRR6 Q9NTJ5 Q9UBF8 Q9Y2I7	ARF1 ARF3 FIG4 INPP5E KIAA0274 KIAA0851 KIAA0981 OCRL OCRL1 PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2G PIK3C3 PIK3R4 PIK4 PIK4CA PIK4CB PIKFYVE PIP5K3 SAC1 SAC3 SACM1L TAX1BP2 TPIP TPTE TPTE2 TRX VAC14 VPS15 VPS34	Homo sapiens (human)
Synthesis of PIPs at the late endosome membrane	1-phosphatidylinositol 3-phosphate 5-kinase Myotubularin-related protein 2 Myotubularin-related protein 4 Myotubularin-related protein 7 Myotubularin-related protein 9 Myotubularin Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphoinositide 3-kinase regulatory subunit 4 Polyphosphoinositide phosphatase Protein VAC14 homolog	O00443 Q08AM6 Q13496 Q13614 Q8NEB9 Q92562 Q96QG7 Q99570 Q9NYA4 Q9Y216 Q9Y2I7	C8orf9 CG2 FIG4 KIAA0274 KIAA0647 KIAA0981 KIAA1073 MTM1 MTMR2 MTMR4 MTMR7 MTMR8 MTMR9 PIK3C2A PIK3C3 PIK3R4 PIKFYVE PIP5K3 SAC3 TAX1BP2 TRX VAC14 VPS15 VPS34 ZFYVE11	Homo sapiens (human)
Regulation of insulin secretion	ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 11 Guanine nucleotide-binding protein G(i) subunit alpha-1 Guanine nucleotide-binding protein G(i) subunit alpha-2 Inositol 1,4,5-trisphosphate receptor type 2 Inositol 1,4,5-trisphosphate receptor type 3 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Insulin Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 S-adenosylhomocysteine hydrolase-like protein 1 Solute carrier family 2, facilitated glucose transporter member 1 Solute carrier family 2, facilitated glucose transporter member 2 Synaptosomal-associated protein 25 Synaptotagmin-5 Syntaxin-1A Syntaxin-binding protein 1 Vesicle-associated membrane protein 2 Voltage-dependent L-type calcium channel subunit alpha-1C Voltage-dependent L-type calcium channel subunit alpha-1D Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent L-type calcium channel subunit beta-3 Voltage-dependent P/Q-type calcium channel subunit alpha-1A Voltage-dependent R-type calcium channel subunit alpha-1E Voltage-dependent calcium channel subunit alpha-2/delta-2 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	O00445 O00555 O43865 O95398 P01308 P04899 P11166 P11168 P17612 P22612 P22694 P54284 P60880 P61764 P63027 P63096 Q01668 Q08289 Q09428 Q13936 Q14571 Q14573 Q14643 Q14654 Q15878 Q16623 Q8WZA2 Q9NY47	ABCC8 AHCYL1 CACH2 CACH3 CACH4 CACH6 CACN2 CACN3 CACN4 CACNA1A CACNA1C CACNA1D CACNA1E CACNA2D2 CACNB2 CACNB3 CACNL1A1 CACNL1A2 CACNL1A4 CACNL1A6 CACNLB2 CACNLB3 CCHL1A1 CCHL1A2 CGEF1 CGEF2 DCAL EPAC EPAC1 EPAC2 GLUT1 GLUT2 GNAI1 GNAI2 GNAI2B HRINS INS INSP3R1 IRBIT ITPR1 ITPR2 ITPR3 KCNJ11 KIAA0558 MYSB PKACA PRKACA PRKACB PRKACG RAPGEF3 RAPGEF4 SLC2A1 SLC2A2 SNAP SNAP25 STX1 STX1A STXBP1 SUR SUR1 SYB2 SYT5 UNC18A VAMP2 XPVKONA	Homo sapiens (human)	G58161NS
RAF/MAP kinase cascade	Alpha-actinin-2 Amphiregulin Angiopoietin-1 receptor Angiopoietin-1 Artemin Astrocytic phosphoprotein PEA-15 Beta-klotho Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Cytokine receptor common subunit beta Cytokine receptor common subunit gamma Disks large homolog 1 Disks large homolog 2 Disks large homolog 3 Disks large homolog 4 Epidermal growth factor receptor Epigen Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Fms-related tyrosine kinase 3 ligand Focal adhesion kinase 1 GDNF family receptor alpha-1 GDNF family receptor alpha-2 GDNF family receptor alpha-3 GDNF family receptor alpha-4 GTPase HRas GTPase NRas Glial cell line-derived neurotrophic factor Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic, NMDA 2D Granulocyte-macrophage colony-stimulating factor receptor subunit alpha Granulocyte-macrophage colony-stimulating factor Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 Interleukin-3 receptor subunit alpha Interleukin-3 Interleukin-5 receptor subunit alpha Interleukin-5 Leucine-rich repeat-containing protein 7 Mast/stem cell growth factor receptor Kit Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Neural cell adhesion molecule 1 Neurofilament light polypeptide Neurturin Persephin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase receptor Ret Protransforming growth factor alpha RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 4 Ral guanine nucleotide dissociation stimulator-like 1 Ral guanine nucleotide dissociation stimulator-like 2 Ral guanine nucleotide dissociation stimulator-like 3 Ral guanine nucleotide dissociation stimulator Ran-binding protein 9 Rap guanine nucleotide exchange factor 2 Ras guanyl-releasing protein 3 Ras-GEF domain-containing family member 1A Ras-specific guanine nucleotide-releasing factor 1 Ras-specific guanine nucleotide-releasing factor 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Receptor-type tyrosine-protein phosphatase alpha SHC-transforming protein 1 SHC-transforming protein 2 SHC-transforming protein 3 Son of sevenless homolog 1 Spectrin alpha chain, erythrocytic 1 Spectrin alpha chain, non-erythrocytic 1 Spectrin beta chain, erythrocytic Spectrin beta chain, non-erythrocytic 1 Spectrin beta chain, non-erythrocytic 2 Spectrin beta chain, non-erythrocytic 4 Spectrin beta chain, non-erythrocytic 5 Tyrosine-protein kinase Fyn Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	O00451 O00459 O14511 O14827 O14944 O15020 O15211 O15399 O15520 O43320 O43559 O60542 O60609 O60674 O76093 O95267 O95750 P00533 P01111 P01112 P01127 P01133 P01135 P01589 P02549 P04141 P04626 P05113 P05230 P06241 P07196 P07949 P08581 P08620 P08700 P09038 P09619 P0DP23 P10721 P10767 P11277 P11487 P13591 P14210 P14784 P15509 P15514 P16234 P18433 P21781 P22455 P23458 P26951 P27361 P27986 P28482 P29353 P31371 P31785 P32927 P35070 P35568 P35609 P36888 P39905 P42336 P42338 P49771 P52333 P56159 P56975 P60568 P78352 P98077 Q01082 Q01344 Q02297 Q02763 Q05397 Q05586 Q07889 Q12959 Q12967 Q13224 Q13554 Q13555 Q13557 Q13813 Q13972 Q15121 Q15389 Q15700 Q3MIN7 Q5T4W7 Q6UW88 Q86Z14 Q8IV61 Q8N9B8 Q8TDF6 Q8WU20 Q8WWG1 Q92529 Q92796 Q96NW7 Q96S59 Q99075 Q99748 Q9GZV9 Q9GZZ7 Q9H254 Q9HCT0 Q9NP95 Q9NRC6 Q9NZL6 Q9UQM7 Q9Y4G8 Q9Y4H2	ACTN2 ANGPT1 AREG AREGB ARTN BSPECV BTC CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CD135 CDC25 CDHF12 CDHR16 CSF2 CSF2R CSF2RA CSF2RB CSF2RY DLG1 DLG2 DLG3 DLG4 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ERK1 ERK2 EVN FAK FAK1 FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 FRS3 FYN GDNF GDNFRA GDNFRB GFRA1 GFRA2 GFRA3 GFRA4 GGF GMCSF GNRP GRB1 GRF1 GRF2 GRIN1 GRIN2B GRIN2D GRP3 GluN2D HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRAS HRAS1 HRGA HST HST2 HSTF1 HSTF2 HUBSPECV HUSPECV HYPF IL15RB IL2 IL2RA IL2RB IL2RG IL3 IL3R IL3RA IL3RB IL5 IL5R IL5RA IL5RB INT2 IRS1 IRS2 JAK1 JAK1A JAK1B JAK2 JAK3 JTK2 KGF KIAA0003 KIAA0302 KIAA0313 KIAA0846 KIAA0959 KIAA0968 KIAA1232 KIAA1308 KIAA1365 KIAA1642 KIT KLB KS3 LAP1 LRRC7 MAPK1 MAPK3 MET MLN19 NCAM NCAM1 NDF NEAS NEFL NEU NF68 NFL NGL NMDAR1 NMDAR2B NMDAR2D NRAPGEP NRAS NRG1 NRG2 NRG3 NRG4 NRTN NSHC NTAK PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PDZGEF1 PEA15 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PRKM1 PRKM2 PRKM3 PSD95 PSPN PTC PTK2 PTPA PTPRA PTPRL2 RAB2L RALGDS RANBP9 RANBPM RAPGEF2 RASGEF1A RASGRF1 RASGRF2 RASGRP RASGRP1 RASGRP3 RASGRP4 RET RETL1 RETL2 RGF RGL RGL1 RGL2 RGL3 RHEPDGFRA SCA5 SCFR SCK SDGF SHC SHC1 SHC2 SHC3 SHCA SHCB SHCC SIS SMDF SOS1 SPTA SPTA1 SPTA2 SPTAN1 SPTB SPTB1 SPTB2 SPTBN1 SPTBN2 SPTBN3 SPTBN4 SPTBN5 STK1 TEK TGFA TIE2 TKF TRNR1 TRNR2 VMCM VMCM1	Homo sapiens (human)
Interleukin-7 signaling	Bromodomain and WD repeat-containing protein 1 Cytokine receptor common subunit gamma Cytokine receptor-like factor 2 Cytokine-inducible SH2-containing protein Hepatocyte growth factor Histone H3.1 Histone H3.2 Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-7 receptor subunit alpha Interleukin-7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 2 Thymic stromal lymphopoietin Transcription activator BRG1 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK3 V(D)J recombination-activating protein 1 V(D)J recombination-activating protein 2	O00459 O14508 O15524 P13232 P14210 P15918 P16871 P23458 P27986 P31785 P35568 P40763 P42229 P51532 P51692 P52333 P55895 P68431 Q71DI3 Q92569 Q969D9 Q9HC73 Q9NSE2 Q9NSI6 Q9Y4H2	APRF BAF190A BRG1 BRWD1 C21orf107 CIS2 CISH CRL2 CRLF2 G18 GRB1 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM HGF HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST2H3A HIST2H3C HIST2H3D HPTA IL2RG IL7 IL7R ILXR IRS1 IRS2 JAK1 JAK1A JAK1B JAK3 PIK3R1 PIK3R2 PIK3R3 RAG1 RAG2 RNF74 SMARCA4 SNF2B SNF2L4 SOCS1 SOCS2 SSI1 SSI2 STAT3 STAT5 STAT5A STAT5B STATI2 TIP3 TSLP TSLPR WDR9	Homo sapiens (human)
Signaling by SCF-KIT	Chymase GRB2-associated-binding protein 2 GRB2-related adapter protein 2 GRB2-related adapter protein GTPase HRas GTPase NRas Growth factor receptor-bound protein 10 Growth factor receptor-bound protein 7 Mast/stem cell growth factor receptor Kit Matrix metalloproteinase-9 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Protein kinase C alpha type Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Receptor-type tyrosine-protein phosphatase U Serine/threonine-protein kinase Chk1 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Son of sevenless homolog 1 Tyrosine-protein kinase Fer Tyrosine-protein kinase Fes/Fps Tyrosine-protein kinase Fyn Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase Tec Tyrosine-protein kinase Yes Tyrosine-protein phosphatase non-receptor type 11	O00459 O14757 O60674 O75791 P01111 P01112 P06239 P06241 P07332 P07947 P07948 P10721 P14780 P15498 P16591 P17252 P23946 P27986 P40763 P42224 P42229 P42336 P42680 P51692 P63000 Q06124 Q07889 Q13322 Q13588 Q14451 Q92569 Q92729 Q9UQC2	APRF CHEK1 CHK1 CLG4B CMA1 CYH CYM FER FES FMI FPS FYN GAB2 GADS GRAP GRAP2 GRB1 GRB10 GRB2L GRB7 GRBIR GRID HRAS HRAS1 JAK2 JTK8 KIAA0207 KIAA0571 KIT LCK LYN MMP9 NRAS PCP2 PIK3CA PIK3R1 PIK3R2 PIK3R3 PKCA PRKACA PRKCA PSCTK4 PTP2C PTPN11 PTPRO PTPRU RAC1 SCFR SHPTP2 SOS1 STAT1 STAT3 STAT5 STAT5A STAT5B TC25 TEC TYK3 VAV VAV1 YES YES1	Homo sapiens (human)
Tie2 Signaling	Angiopoietin-1 receptor Angiopoietin-1 Angiopoietin-2 Angiopoietin-4 Docking protein 2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 14 Growth factor receptor-bound protein 7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform SHC-transforming protein 1 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	O00459 O15123 O60496 P01111 P01112 P27986 P29353 P42336 P42338 Q02763 Q06124 Q07889 Q14449 Q14451 Q15389 Q9Y264	ANG3 ANG4 ANGPT1 ANGPT2 ANGPT4 DOK2 GRB1 GRB14 GRB7 HRAS HRAS1 KIAA0003 NRAS PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PTP2C PTPN11 SHC SHC1 SHCA SHPTP2 SOS1 TEK TIE2 VMCM VMCM1	Homo sapiens (human)
VEGFA-VEGFR2 Pathway	Abl interactor 1 Abl interactor 2 Actin-binding protein WASF1 Actin-binding protein WASF2 Actin-binding protein WASF3 Adapter molecule crk BAR/IMD domain-containing adapter protein 2 Breast cancer anti-estrogen resistance protein 1 Cell division control protein 42 homolog Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytoplasmic FMR1-interacting protein 1 Cytoplasmic FMR1-interacting protein 2 Cytoplasmic protein NCK2 Dedicator of cytokinesis protein 1 Engulfment and cell motility protein 1 Engulfment and cell motility protein 2 Focal adhesion kinase 1 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Heat shock protein HSP 90-alpha Heat shock protein beta-1 Integrin alpha-V Integrin beta-3 MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 13 Mitogen-activated protein kinase 14 Nck-associated protein 1-like Nck-associated protein 1 Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Neutrophil cytosol factor 4 Paxillin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Protein BRICK1 Protein-tyrosine kinase 2-beta Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Rho-associated protein kinase 1 Rho-associated protein kinase 2 SH2 domain-containing adapter protein B SH2 domain-containing protein 2A SH2/SH3 adapter protein NCK1 SHC-transforming protein 2 Serine/threonine-protein kinase PAK 2 Transforming protein RhoA Tyrosine-protein kinase Fyn Tyrosine-protein kinase receptor UFO Vascular endothelial growth factor receptor 2 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	O00459 O15264 O43639 O75116 P04792 P04839 P05106 P06241 P06756 P07900 P13498 P14598 P15498 P16333 P17612 P19878 P22612 P22694 P27986 P30530 P35968 P42336 P42338 P46108 P49023 P49137 P52735 P53778 P55160 P56945 P60953 P61586 P63000 P98077 Q05397 Q13177 Q13464 Q14185 Q14289 Q15080 Q15464 Q15759 Q16539 Q16644 Q7L576 Q8IZP0 Q8WUW1 Q92556 Q92558 Q96F07 Q96JJ3 Q9NP31 Q9NYB9 Q9UKW4 Q9UPY6 Q9UQB8 Q9Y2A7 Q9Y6W5	ABI1 ABI2 ARGBPIA ARH12 ARHA AXL BAIAP2 BCAR1 BRK1 C3orf10 CAS CASS1 CDC42 CED12A CRK CRKAS CSBP CSBP1 CSBP2 CSPB1 CYBA CYBB CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 ERK6 FAK FAK1 FAK2 FLK1 FYN GP3A GRB1 GRB4 HEM1 HEM2 HSP27 HSP28 HSP90A HSP90AA1 HSPB1 HSPC1 HSPCA ITGAV ITGB3 KDR KIAA0068 KIAA0269 KIAA0281 KIAA0587 KIAA0619 KIAA0900 KIAA1168 KIAA1834 MAPK11 MAPK12 MAPK13 MAPK14 MAPKAPK2 MAPKAPK3 MSK8 MXI2 NAP1 NCF1 NCF2 NCF4 NCK NCK1 NCK2 NCKAP1 NCKAP1L NOX2 NOXA2 NOXO2 P67PHOX PAK2 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PIR121 PKACA PRKACA PRKACB PRKACG PRKM11 PRKM13 PTK2 PTK2B PXN PYK2 RAC1 RAFTK RHO12 RHOA ROCK1 ROCK2 SAPK2 SAPK2A SAPK2B SAPK3 SAPK4 SCAP SCAR1 SCAR3 SCK SH2D2A SH3PXD1A SH3PXD4 SHB SHC2 SHCB SSH3BP1 TC25 TSAD UFO VAV VAV1 VAV2 VAV3 VEGFR2 VNRA VRAP VTNR WASF1 WASF2 WASF3 WAVE1 WAVE2 WAVE3	Homo sapiens (human)
PI3K Cascade	Beta-klotho Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphoinositide 3-kinase regulatory subunit 4 Receptor-type tyrosine-protein kinase FLT3 Toll-like receptor 9 Tyrosine-protein phosphatase non-receptor type 11	O00459 O15520 O43320 O76093 O95750 P05230 P08620 P09038 P10767 P11487 P21781 P22455 P27986 P31371 P35568 P36888 P42336 P42338 P49771 Q06124 Q13480 Q86Z14 Q8NEB9 Q8WU20 Q99570 Q9GZV9 Q9HCT0 Q9NP95 Q9NR96 Q9UQC2 Q9Y4H2	CD135 FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB1 HST HST2 HSTF1 HSTF2 HYPF INT2 IRS1 IRS2 JTK2 KGF KIAA0571 KLB KS3 PIK3C1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTP2C PTPN11 SHPTP2 STK1 TKF TLR9 VPS15 VPS34	Homo sapiens (human)
GPVI-mediated activation cascade	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 3-phosphoinositide-dependent protein kinase 1 C-type lectin domain family 1 member B Cell division control protein 42 homolog Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 High affinity immunoglobulin epsilon receptor subunit gamma Linker for activation of T-cells family member 1 Lymphocyte cytosolic protein 2 Megakaryocyte and platelet inhibitory receptor G6b Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Phosphoinositide 3-kinase regulatory subunit 5 Phosphoinositide 3-kinase regulatory subunit 6 Platelet glycoprotein VI Podoplanin Protein kinase C zeta type Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoG Transforming protein RhoA Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6	O00459 O15530 O43561 O95866 P06239 P06241 P07948 P15153 P15498 P16885 P27986 P29350 P30273 P42336 P42338 P43405 P48736 P52735 P60953 P61586 P62745 P63000 P84095 Q05513 Q06124 Q13094 Q5UE93 Q86YL7 Q8WYR1 Q92569 Q9HCN6 Q9P126 Q9UKW4	ARH12 ARH6 ARHA ARHB ARHG C17orf38 C6orf25 CDC42 CLEC1B CLEC2 FCER1G FYN G6B G6B-B GP36 GP6 GRB1 HCP JTK8 LAT LCK LCP2 LYN MPIG6B PDK1 PDPK1 PDPN PIK3C1 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PKC2 PLCG2 PRKCZ PTP1C PTP2C PTPN11 PTPN6 RAC1 RAC2 RHO12 RHOA RHOB RHOG SHPTP2 SYK TC25 VAV VAV1 VAV2 VAV3	Homo sapiens (human)
CD28 dependent PI3K/Akt signaling	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Membrane protein Mitogen-activated protein kinase kinase kinase 14 Mitogen-activated protein kinase kinase kinase 8 Nucleoprotein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proline-rich protein 5 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Serine/threonine-protein kinase mTOR T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck	O00459 O15530 P06239 P06241 P0DTC5 P0DTC9 P10747 P27986 P31749 P31751 P33681 P41279 P42081 P42336 P42345 P85299 Q5T1C6 Q6R327 Q92569 Q96RU7 Q99558 Q9BPZ7 Q9BVC4 Q9Y243	AKT1 AKT2 AKT3 C20orf97 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 COT CTMP ESTF FRAP FRAP1 FRAP2 FYN GBL GRB1 KIAA1999 LAB7 LCK LST8 M MAP3K14 MAP3K8 MAPKAP1 MIP1 MLST8 MTOR N NIK NIPK PDK1 PDPK1 PIK3CA PIK3R1 PIK3R2 PIK3R3 PKB PKBG PROTOR1 PRR5 RAC RAFT1 RAPT1 RICTOR SIN1 SKIP3 THEM4 TRB3 TRIB3	Homo sapiens (human)
RND1 GTPase cycle	Aldehyde dehydrogenase family 3 member A2 Ankyrin repeat domain-containing protein 26 Carboxypeptidase D Caveolin-1 DEP domain-containing protein 1B Desmoplakin Disks large homolog 5 Dystonin Ephrin type-A receptor 2 Epithelial-stromal interaction protein 1 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Flotillin-2 Girdin Growth factor receptor-bound protein 7 Inner nuclear membrane protein Man1 Kinase D-interacting substrate of 220 kDa Kinesin-like protein KIF14 Mucin-13 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Plakophilin-4 Pleckstrin homology domain-containing family G member 5 Plexin-A1 Protein FAM135A Protein FAM83B RNA-binding motif protein, X chromosome Ras GTPase-activating protein nGAP Ras-related protein R-Ras2 Rho GTPase-activating protein 35 Rho GTPase-activating protein 5 Rho-related GTP-binding protein Rho6 Stathmin-2 Stress-induced-phosphoprotein 1 Thioredoxin-like protein 1 Transferrin receptor protein 1 Transmembrane protein 59 Tyrosine-protein phosphatase non-receptor type 13 UBX domain-containing protein 11 Vang-like protein 1 Vang-like protein 2 tRNA (34-2'-O)-methyltransferase regulator WDR6	O00459 O43396 O43559 O75976 O94827 P02786 P15924 P27986 P29317 P31948 P38159 P51648 P62070 Q03001 Q03135 Q12923 Q13017 Q14254 Q14451 Q15058 Q3V6T2 Q5T0W9 Q5T124 Q8TAA9 Q8TDM6 Q8WU20 Q8WUY9 Q92730 Q93045 Q96J88 Q99569 Q9BXS4 Q9H3R2 Q9NNW5 Q9NRY4 Q9P2D6 Q9UIW2 Q9UJF2 Q9ULH0 Q9ULK5 Q9UPS8 Q9Y2U8	ALDH10 ALDH3A2 ANKRD26 APE ARHGAP35 ARHGAP5 ARMS BP230 BP240 BPAG1 C1orf8 C6orf143 CAV CAV1 CCDC88A CPD DEPDC1B DLG5 DMH DRCC1 DSP DST DT ECK EPHA2 EPSTI1 ESA1 FALDH FAM135A FAM83B FLOT2 FRS2 FRS3 GRB1 GRB7 GRDN GRF1 GRLF1 HNRPG KIAA0042 KIAA0583 KIAA0720 KIAA0728 KIAA1074 KIAA1212 KIAA1215 KIAA1250 KIAA1411 KIAA1722 KIDINS220 KIF14 LEMD3 M17S1 MAN1 MUC13 NGAP NOV P190A PDLG PIK3R1 PIK3R2 PKP4 PLEKHG5 PLXN1 PLXNA1 PNP1 PTP1E PTPL1 PTPN13 RASAL2 RBMX RBMXP1 RECC RHO6 RHOGAP5 RND1 RRAS2 SCG10 SCGN10 SOC STB1 STB2 STIP1 STMN2 TC21 TFRC TMEM59 TRP32 TXL TXNL TXNL1 UBXD5 UBXN11 VANGL1 VANGL2 WDR6 XTP8 p190ARHOGAP	Homo sapiens (human)

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