GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1651 - 1675** of **2090** in total

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Pathway Name	Protein Name	UniProt ID ▼	Gene Symbol	Organism	GlyTouCan ID
ECM proteoglycans	Aggrecan core protein Agrin Asporin Basement membrane-specific heparan sulfate proteoglycan core protein Biglycan Brevican core protein Cartilage matrix protein Cartilage oligomeric matrix protein Collagen alpha-1(IX) chain Collagen alpha-2(IX) chain Collagen alpha-3(IX) chain Decorin Dentin matrix acidic phosphoprotein 1 Dentin sialophosphoprotein Dystroglycan 1 Fibromodulin Hyaluronan and proteoglycan link protein 1 Integrin alpha-2 Integrin alpha-7 Integrin alpha-8 Integrin alpha-9 Integrin alpha-IIb Integrin alpha-V Integrin alpha-X Integrin beta-1 Integrin beta-3 Integrin beta-5 Integrin beta-6 Integrin-binding sialoprotein Laminin subunit alpha-1 Laminin subunit alpha-2 Laminin subunit alpha-3 Laminin subunit alpha-4 Laminin subunit alpha-5 Laminin subunit beta-1 Laminin subunit beta-2 Laminin subunit gamma-1 Low-density lipoprotein receptor-related protein 4 Lumican Matrilin-3 Matrilin-4 Muscle, skeletal receptor tyrosine-protein kinase Neural cell adhesion molecule 1 Neurocan core protein Plasminogen activator inhibitor 1 Receptor-type tyrosine-protein phosphatase S SPARC Tenascin-N Tenascin-R Tenascin-X Tenascin Transforming growth factor beta-1 proprotein Transforming growth factor beta-2 proprotein Transforming growth factor beta-3 proprotein Versican core protein Vitronectin	O00468 O14594 O15146 O15230 O15232 O75096 O95460 P01137 P04004 P05106 P05121 P05556 P06756 P07585 P07942 P08514 P09486 P10600 P10915 P11047 P13591 P13611 P16112 P17301 P18084 P18564 P20702 P20849 P21810 P21815 P21941 P22105 P24043 P24821 P25391 P49747 P51884 P53708 P55268 P61812 P98160 Q06828 Q13316 Q13332 Q13683 Q13797 Q14050 Q14055 Q14118 Q16363 Q16787 Q92752 Q96GW7 Q9BXN1 Q9NZW4 Q9UQP3	ACAN AGC1 AGRIN AGRN ASPN BCAN BEHAB BGN BNSP CD11C CD49B CMP COL9A1 COL9A2 COL9A3 COMP CRTL1 CRTM CSPG1 CSPG2 CSPG3 CSPG7 DAG1 DCN DMP1 DSPP FM FMOD FNRB GP2B GP3A HAPLN1 HSPG2 HXB HXBL IBSP ITGA2 ITGA2B ITGA7 ITGA8 ITGA9 ITGAB ITGAV ITGAX ITGB1 ITGB3 ITGB5 ITGB6 KIAA0533 KIAA0816 KIAA1907 LAMA LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMC1 LAMM LAMNA LAMS LDC LRP10 LRP4 LUM MATN1 MATN3 MATN4 MDF2 MEGF7 MSK12 MSK16 MSK8 MUSK NCAM NCAM1 NCAN NEUR ON PAI1 PLANH1 PLAP1 PTPRS SERPINE1 SLRR1A SLRR1B SLRR1C SLRR2D SLRR2E SPARC TGFB TGFB1 TGFB2 TGFB3 TNC TNN TNR TNW TNX TNXB TNXB1 TNXB2 VCAN VNRA VTN VTNR XB	Homo sapiens (human)
Lysosomal oligosaccharide catabolism	Alpha-mannosidase 2C1 Beta-mannosidase Epididymis-specific alpha-mannosidase Lysosomal alpha-mannosidase	O00462 O00754 Q9NTJ4 Q9Y2E5	KIAA0935 LAMAN MAN2B1 MAN2B2 MAN2C1 MANA MANA1 MANB MANB1 MANBA	Homo sapiens (human)	G00027MO G25577BM G28233ME G70323CJ G90333CG
Intra-Golgi traffic	ADP-ribosylation factor 1 Alkaline phosphatase, placental type Alpha-mannosidase 2 Alpha-mannosidase 2x Alpha-soluble NSF attachment protein BET1-like protein Beta-soluble NSF attachment protein Conserved oligomeric Golgi complex subunit 1 Conserved oligomeric Golgi complex subunit 2 Conserved oligomeric Golgi complex subunit 3 Conserved oligomeric Golgi complex subunit 4 Conserved oligomeric Golgi complex subunit 5 Conserved oligomeric Golgi complex subunit 6 Conserved oligomeric Golgi complex subunit 7 Conserved oligomeric Golgi complex subunit 8 Cytohesin-1 Cytohesin-2 Cytohesin-3 Cytohesin-4 Gamma-soluble NSF attachment protein Golgi SNAP receptor complex member 1 Golgi SNAP receptor complex member 2 Golgi integral membrane protein 4 Golgin subfamily A member 5 Guanine nucleotide exchange factor subunit RIC1 Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC Protein CASP RAB6A-GEF complex partner protein 2 Ras-related protein Rab-30 Ras-related protein Rab-33B Ras-related protein Rab-36 Ras-related protein Rab-39A Ras-related protein Rab-41 Synaptobrevin homolog YKT6 Synaptosomal-associated protein 29 Syntaxin-16 Syntaxin-5 Syntaxin-6 Thyroid receptor-interacting protein 11 Vacuolar protein sorting-associated protein 45 Vesicle transport through interaction with t-SNAREs homolog 1A Vesicle-fusing ATPase	O00461 O14653 O14662 O15498 O43739 O43752 O60476 O95249 O95721 O95755 P05187 P33908 P46459 P49641 P54920 P83436 P84077 Q13190 Q13948 Q14746 Q14964 Q15438 Q15643 Q15771 Q16706 Q4ADV7 Q5JT25 Q8TBA6 Q8WTW3 Q92546 Q96AJ9 Q96JB2 Q96MW5 Q99418 Q99747 Q9H082 Q9H115 Q9H9E3 Q9NR34 Q9NRW7 Q9NYM9 Q9UIA0 Q9UP83 Q9Y2V7	ALPP ARF1 ARNO ARNO3 BET1L CEV14 CIP150 COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8 CUTL1 CUX1 CYT4 CYTH1 CYTH2 CYTH3 CYTH4 D17S811E GIMPC GOLGA5 GOLIM4 GOLPH4 GOLTC1 GOSR1 GOSR2 GPP130 GRP1 GS15 GS27 GS28 GTC90 KIAA0258 KIAA1134 KIAA1381 KIAA1432 LDLB LDLC MAN1A1 MAN1A2 MAN1A3 MAN1B MAN1C MAN1C1 MAN2A1 MAN2A2 MANA2 MANA2X NAPA NAPB NAPG NSF PLAP PSCD1 PSCD2 PSCD2L PSCD3 PSCD4 RAB30 RAB33B RAB36 RAB39 RAB39A RAB41 RETII RFG5 RGP1 RIC1 SEC34 SNAP29 SNAPA SNAPB SNAPG STX16 STX5 STX5A STX6 TRIP11 VPS45 VPS45A VPS45B VTI1A YKT6	Homo sapiens (human)
IRS-mediated signalling	Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O00459 P27986 P35568 P42336 P42338 Q9Y4H2	GRB1 IRS1 IRS2 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2	Homo sapiens (human)
Signaling by LTK	ALK and LTK ligand 1 ALK and LTK ligand 2 Activated CDC42 kinase 1 Growth factor receptor-bound protein 2 Insulin receptor substrate 1 Leukocyte tyrosine kinase receptor Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Son of sevenless homolog 1	O00459 P27986 P29376 P35568 P42336 P42338 P62993 Q07889 Q07912 Q6UX46 Q6UXT8	ACK1 ALKAL1 ALKAL2 ASH FAM150A FAM150B GRB1 GRB2 IRS1 LTK PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 SOS1 TNK2 TYK1	Homo sapiens (human)
Signaling by LTK in cancer	CAP-Gly domain-containing linker protein 1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O00459 P27361 P27986 P28482 P30622 P42336 P42338	CLIP1 CYLN1 ERK1 ERK2 GRB1 MAPK1 MAPK3 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PRKM1 PRKM2 PRKM3 RSN	Homo sapiens (human)
PI3K/AKT activation	Beta-nerve growth factor High affinity nerve growth factor receptor Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Transforming protein RhoA	O00459 P01138 P04629 P27986 P35568 P42336 P42338 P61586 Q9Y4H2	ARH12 ARHA GRB1 IRS1 IRS2 MTC NGF NGFB NTRK1 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 RHO12 RHOA TRK TRKA	Homo sapiens (human)
Signaling by PDGFRA extracellular domain mutants	GTPase HRas GTPase NRas Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Son of sevenless homolog 1	O00459 P01111 P01112 P16234 P27986 P40763 P42224 P42336 P42338 Q07889	APRF GRB1 HRAS HRAS1 NRAS PDGFR2 PDGFRA PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 RHEPDGFRA SOS1 STAT1 STAT3	Homo sapiens (human)
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	GTPase HRas GTPase NRas Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Son of sevenless homolog 1	O00459 P01111 P01112 P16234 P27986 P40763 P42224 P42336 P42338 Q07889	APRF GRB1 HRAS HRAS1 NRAS PDGFR2 PDGFRA PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 RHEPDGFRA SOS1 STAT1 STAT3	Homo sapiens (human)
Signaling by ALK	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 ALK and LTK ligand 1 ALK and LTK ligand 2 ALK tyrosine kinase receptor Fibroblast growth factor receptor substrate 2 Insulin receptor substrate 1 Midkine Myc proto-oncogene protein N-myc proto-oncogene protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Pleiotrophin Signal transducer and activator of transcription 3 Tyrosine-protein kinase JAK3 Tyrosine-protein phosphatase non-receptor type 6	O00459 P01106 P04198 P19174 P21246 P21741 P27986 P29350 P35568 P40763 P42336 P42338 P52333 Q6UX46 Q6UXT8 Q8WU20 Q9UM73	ALK ALKAL1 ALKAL2 APRF BHLHE37 BHLHE39 FAM150A FAM150B FRS2 GRB1 HBNF1 HCP IRS1 JAK3 MDK MK1 MYC MYCN NEGF1 NEGF2 NMYC PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLC1 PLCG1 PTN PTP1C PTPN6 STAT3	Homo sapiens (human)
Costimulation by the CD28 family	B- and T-lymphocyte attenuator ICOS ligand Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tumor necrosis factor receptor superfamily member 14 Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6	O00459 O75144 P27986 P29350 P42336 Q06124 Q7Z6A9 Q92569 Q92956	B7H2 B7RP1 BTLA GRB1 HCP HVEA HVEM ICOSL ICOSLG KIAA0653 PIK3CA PIK3R1 PIK3R2 PIK3R3 PTP1C PTP2C PTPN11 PTPN6 SHPTP2 TNFRSF14	Homo sapiens (human)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	GTPase HRas GTPase NRas Mast/stem cell growth factor receptor Kit Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Son of sevenless homolog 1 Tyrosine-protein kinase Fyn Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes	O00459 O60674 P01111 P01112 P06239 P06241 P07947 P07948 P10721 P27986 P40763 P42224 P42229 P42336 P51692 Q07889 Q92569	APRF FYN GRB1 HRAS HRAS1 JAK2 JTK8 KIT LCK LYN NRAS PIK3CA PIK3R1 PIK3R2 PIK3R3 SCFR SOS1 STAT1 STAT3 STAT5 STAT5A STAT5B YES YES1	Homo sapiens (human)
DAP12 signaling	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Beta-2-microglobulin GRB2-related adapter protein 2 GTPase HRas GTPase NRas Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 HLA class I histocompatibility antigen, alpha chain E Lymphocyte cytosolic protein 2 NKG2-C type II integral membrane protein NKG2-D type II integral membrane protein Natural killer cells antigen CD94 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Ras-related C3 botulinum toxin substrate 1 Son of sevenless homolog 1 TYRO protein tyrosine kinase-binding protein Triggering receptor expressed on myeloid cells 2 Tyrosine-protein kinase BTK Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein kinase SYK	O00459 O43914 O75791 P01111 P01112 P06239 P06241 P13747 P16885 P19174 P26717 P26718 P27986 P42336 P42338 P43405 P52735 P61769 P63000 Q06187 Q07889 Q13094 Q13241 Q9NZC2 Q9UKW4	AGMX1 ATK B2M BPK BTK CD94 D12S2489E DAP12 FYN GADS GRAP2 GRB1 GRB2L GRID HLA-6.2 HLA-E HLAE HRAS HRAS1 KARAP KLRC2 KLRD1 KLRK1 LCK LCP2 NKG2C NKG2D NRAS PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLC1 PLCG1 PLCG2 RAC1 SOS1 SYK TC25 TREM2 TYROBP VAV2 VAV3	Homo sapiens (human)
Downstream signal transduction	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Adapter molecule crk Breast cancer anti-estrogen resistance protein 1 Crk-like protein Cytoplasmic protein NCK2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Proto-oncogene tyrosine-protein kinase Src Rap guanine nucleotide exchange factor 1 Ras GTPase-activating protein 1 SH2/SH3 adapter protein NCK1 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Signal transducer and activator of transcription 6 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	O00459 O43639 P01111 P01112 P01127 P09619 P12931 P16234 P16333 P19174 P20936 P27986 P40763 P42224 P42226 P42229 P42336 P42338 P46108 P46109 P51692 P56945 Q06124 Q07889 Q13905 Q14451	APRF BCAR1 CAS CASS1 CRK CRKAS CRKL GAP GRB1 GRB4 GRB7 GRF2 HRAS HRAS1 NCK NCK1 NCK2 NRAS PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLC1 PLCG1 PTP2C PTPN11 RAPGEF1 RASA RASA1 RHEPDGFRA SHPTP2 SIS SOS1 SRC SRC1 STAT1 STAT3 STAT5 STAT5A STAT5B STAT6	Homo sapiens (human)
RND3 GTPase cycle	Ankyrin repeat domain-containing protein 26 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 Carboxypeptidase D Caveolin-1 Creatine kinase B-type Cytoskeleton-associated protein 4 DEP domain-containing protein 1B Desmoglein-1 Desmoplakin Disks large homolog 5 Dystonin Ephrin type-A receptor 2 Flotillin-2 Girdin Inner nuclear membrane protein Man1 Kinectin Mucin-13 Nischarin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol-binding clathrin assembly protein Plakophilin-4 Pleckstrin homology domain-containing family G member 5 Probable ATP-dependent RNA helicase DDX4 Protein FAM83B Protein scribble homolog RNA-binding motif protein, X chromosome Ras GTPase-activating protein nGAP Rho GTPase-activating protein 21 Rho GTPase-activating protein 35 Rho GTPase-activating protein 5 Rho-associated protein kinase 1 Rho-related GTP-binding protein RhoE Semaphorin-4F Thioredoxin-like protein 1 Tropomodulin-3 Tyrosine-protein phosphatase non-receptor type 13 UBX domain-containing protein 11 Vang-like protein 1 Vang-like protein 2 tRNA (34-2'-O)-methyltransferase regulator WDR6	O00459 O43396 O75976 O94827 O95754 P12277 P15924 P27986 P29317 P38159 P61587 Q02413 Q03001 Q03135 Q07065 Q12923 Q13017 Q13464 Q13492 Q13829 Q14160 Q14254 Q3V6T2 Q5T0W9 Q5T124 Q5T5U3 Q86UP2 Q8TAA9 Q8TDM6 Q8WUY9 Q8WZ19 Q99569 Q9H3R2 Q9NNW5 Q9NQI0 Q9NRY4 Q9NYL9 Q9UJF2 Q9ULK5 Q9UPS8 Q9Y2I1 Q9Y2U8	ANKRD26 APE ARHE ARHGAP10 ARHGAP21 ARHGAP35 ARHGAP5 BACURD1 BACURD2 BP230 BP240 BPAG1 C6orf143 CALM CAV CAV1 CCDC88A CDHF4 CG1 CKAP4 CKB CKBB CPD CRIB1 DDX4 DEPDC1B DLG5 DMH DRCC1 DSG1 DSP DST DT ECK EDP1 EPHA2 ESA1 FAM83B FLOT2 GRB1 GRDN GRF1 GRLF1 HNRPG IRAS KCTD13 KIAA0004 KIAA0147 KIAA0583 KIAA0720 KIAA0728 KIAA0975 KIAA1074 KIAA1212 KIAA1215 KIAA1424 KIAA1722 KTN1 LAP4 LEMD3 M17S1 MAN1 MUC13 NGAP NISCH P190A PDIP1 PDLG PICALM PIK3R1 PIK3R2 PKP4 PLEKHG5 PNP1 POLDIP1 PTP1E PTPL1 PTPN13 RASAL2 RBMX RBMXP1 RECC RHO8 RHOE RHOGAP5 RND3 ROCK1 SCRB1 SCRIB SEMA4F SEMAM SEMAW SOC STB1 STB2 TMOD3 TNFAIP1 TRP32 TXL TXNL TXNL1 UBXD5 UBXN11 VANGL1 VANGL2 VARTUL VASA WDR6 XTP8 p190ARHOGAP	Homo sapiens (human)
RND1 GTPase cycle	Aldehyde dehydrogenase family 3 member A2 Ankyrin repeat domain-containing protein 26 Carboxypeptidase D Caveolin-1 DEP domain-containing protein 1B Desmoplakin Disks large homolog 5 Dystonin Ephrin type-A receptor 2 Epithelial-stromal interaction protein 1 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Flotillin-2 Girdin Growth factor receptor-bound protein 7 Inner nuclear membrane protein Man1 Kinase D-interacting substrate of 220 kDa Kinesin-like protein KIF14 Mucin-13 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Plakophilin-4 Pleckstrin homology domain-containing family G member 5 Plexin-A1 Protein FAM135A Protein FAM83B RNA-binding motif protein, X chromosome Ras GTPase-activating protein nGAP Ras-related protein R-Ras2 Rho GTPase-activating protein 35 Rho GTPase-activating protein 5 Rho-related GTP-binding protein Rho6 Stathmin-2 Stress-induced-phosphoprotein 1 Thioredoxin-like protein 1 Transferrin receptor protein 1 Transmembrane protein 59 Tyrosine-protein phosphatase non-receptor type 13 UBX domain-containing protein 11 Vang-like protein 1 Vang-like protein 2 tRNA (34-2'-O)-methyltransferase regulator WDR6	O00459 O43396 O43559 O75976 O94827 P02786 P15924 P27986 P29317 P31948 P38159 P51648 P62070 Q03001 Q03135 Q12923 Q13017 Q14254 Q14451 Q15058 Q3V6T2 Q5T0W9 Q5T124 Q8TAA9 Q8TDM6 Q8WU20 Q8WUY9 Q92730 Q93045 Q96J88 Q99569 Q9BXS4 Q9H3R2 Q9NNW5 Q9NRY4 Q9P2D6 Q9UIW2 Q9UJF2 Q9ULH0 Q9ULK5 Q9UPS8 Q9Y2U8	ALDH10 ALDH3A2 ANKRD26 APE ARHGAP35 ARHGAP5 ARMS BP230 BP240 BPAG1 C1orf8 C6orf143 CAV CAV1 CCDC88A CPD DEPDC1B DLG5 DMH DRCC1 DSP DST DT ECK EPHA2 EPSTI1 ESA1 FALDH FAM135A FAM83B FLOT2 FRS2 FRS3 GRB1 GRB7 GRDN GRF1 GRLF1 HNRPG KIAA0042 KIAA0583 KIAA0720 KIAA0728 KIAA1074 KIAA1212 KIAA1215 KIAA1250 KIAA1411 KIAA1722 KIDINS220 KIF14 LEMD3 M17S1 MAN1 MUC13 NGAP NOV P190A PDLG PIK3R1 PIK3R2 PKP4 PLEKHG5 PLXN1 PLXNA1 PNP1 PTP1E PTPL1 PTPN13 RASAL2 RBMX RBMXP1 RECC RHO6 RHOGAP5 RND1 RRAS2 SCG10 SCGN10 SOC STB1 STB2 STIP1 STMN2 TC21 TFRC TMEM59 TRP32 TXL TXNL TXNL1 UBXD5 UBXN11 VANGL1 VANGL2 WDR6 XTP8 p190ARHOGAP	Homo sapiens (human)
CD28 dependent PI3K/Akt signaling	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Membrane protein Mitogen-activated protein kinase kinase kinase 14 Mitogen-activated protein kinase kinase kinase 8 Nucleoprotein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proline-rich protein 5 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Serine/threonine-protein kinase mTOR T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck	O00459 O15530 P06239 P06241 P0DTC5 P0DTC9 P10747 P27986 P31749 P31751 P33681 P41279 P42081 P42336 P42345 P85299 Q5T1C6 Q6R327 Q92569 Q96RU7 Q99558 Q9BPZ7 Q9BVC4 Q9Y243	AKT1 AKT2 AKT3 C20orf97 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 COT CTMP ESTF FRAP FRAP1 FRAP2 FYN GBL GRB1 KIAA1999 LAB7 LCK LST8 M MAP3K14 MAP3K8 MAPKAP1 MIP1 MLST8 MTOR N NIK NIPK PDK1 PDPK1 PIK3CA PIK3R1 PIK3R2 PIK3R3 PKB PKBG PROTOR1 PRR5 RAC RAFT1 RAPT1 RICTOR SIN1 SKIP3 THEM4 TRB3 TRIB3	Homo sapiens (human)
GPVI-mediated activation cascade	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 3-phosphoinositide-dependent protein kinase 1 C-type lectin domain family 1 member B Cell division control protein 42 homolog Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 High affinity immunoglobulin epsilon receptor subunit gamma Linker for activation of T-cells family member 1 Lymphocyte cytosolic protein 2 Megakaryocyte and platelet inhibitory receptor G6b Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Phosphoinositide 3-kinase regulatory subunit 5 Phosphoinositide 3-kinase regulatory subunit 6 Platelet glycoprotein VI Podoplanin Protein kinase C zeta type Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoG Transforming protein RhoA Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6	O00459 O15530 O43561 O95866 P06239 P06241 P07948 P15153 P15498 P16885 P27986 P29350 P30273 P42336 P42338 P43405 P48736 P52735 P60953 P61586 P62745 P63000 P84095 Q05513 Q06124 Q13094 Q5UE93 Q86YL7 Q8WYR1 Q92569 Q9HCN6 Q9P126 Q9UKW4	ARH12 ARH6 ARHA ARHB ARHG C17orf38 C6orf25 CDC42 CLEC1B CLEC2 FCER1G FYN G6B G6B-B GP36 GP6 GRB1 HCP JTK8 LAT LCK LCP2 LYN MPIG6B PDK1 PDPK1 PDPN PIK3C1 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PKC2 PLCG2 PRKCZ PTP1C PTP2C PTPN11 PTPN6 RAC1 RAC2 RHO12 RHOA RHOB RHOG SHPTP2 SYK TC25 VAV VAV1 VAV2 VAV3	Homo sapiens (human)
PI3K Cascade	Beta-klotho Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphoinositide 3-kinase regulatory subunit 4 Receptor-type tyrosine-protein kinase FLT3 Toll-like receptor 9 Tyrosine-protein phosphatase non-receptor type 11	O00459 O15520 O43320 O76093 O95750 P05230 P08620 P09038 P10767 P11487 P21781 P22455 P27986 P31371 P35568 P36888 P42336 P42338 P49771 Q06124 Q13480 Q86Z14 Q8NEB9 Q8WU20 Q99570 Q9GZV9 Q9HCT0 Q9NP95 Q9NR96 Q9UQC2 Q9Y4H2	CD135 FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB1 HST HST2 HSTF1 HSTF2 HYPF INT2 IRS1 IRS2 JTK2 KGF KIAA0571 KLB KS3 PIK3C1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTP2C PTPN11 SHPTP2 STK1 TKF TLR9 VPS15 VPS34	Homo sapiens (human)
VEGFA-VEGFR2 Pathway	Abl interactor 1 Abl interactor 2 Actin-binding protein WASF1 Actin-binding protein WASF2 Actin-binding protein WASF3 Adapter molecule crk BAR/IMD domain-containing adapter protein 2 Breast cancer anti-estrogen resistance protein 1 Cell division control protein 42 homolog Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytoplasmic FMR1-interacting protein 1 Cytoplasmic FMR1-interacting protein 2 Cytoplasmic protein NCK2 Dedicator of cytokinesis protein 1 Engulfment and cell motility protein 1 Engulfment and cell motility protein 2 Focal adhesion kinase 1 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Heat shock protein HSP 90-alpha Heat shock protein beta-1 Integrin alpha-V Integrin beta-3 MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 13 Mitogen-activated protein kinase 14 Nck-associated protein 1-like Nck-associated protein 1 Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Neutrophil cytosol factor 4 Paxillin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Protein BRICK1 Protein-tyrosine kinase 2-beta Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Rho-associated protein kinase 1 Rho-associated protein kinase 2 SH2 domain-containing adapter protein B SH2 domain-containing protein 2A SH2/SH3 adapter protein NCK1 SHC-transforming protein 2 Serine/threonine-protein kinase PAK 2 Transforming protein RhoA Tyrosine-protein kinase Fyn Tyrosine-protein kinase receptor UFO Vascular endothelial growth factor receptor 2 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	O00459 O15264 O43639 O75116 P04792 P04839 P05106 P06241 P06756 P07900 P13498 P14598 P15498 P16333 P17612 P19878 P22612 P22694 P27986 P30530 P35968 P42336 P42338 P46108 P49023 P49137 P52735 P53778 P55160 P56945 P60953 P61586 P63000 P98077 Q05397 Q13177 Q13464 Q14185 Q14289 Q15080 Q15464 Q15759 Q16539 Q16644 Q7L576 Q8IZP0 Q8WUW1 Q92556 Q92558 Q96F07 Q96JJ3 Q9NP31 Q9NYB9 Q9UKW4 Q9UPY6 Q9UQB8 Q9Y2A7 Q9Y6W5	ABI1 ABI2 ARGBPIA ARH12 ARHA AXL BAIAP2 BCAR1 BRK1 C3orf10 CAS CASS1 CDC42 CED12A CRK CRKAS CSBP CSBP1 CSBP2 CSPB1 CYBA CYBB CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 ERK6 FAK FAK1 FAK2 FLK1 FYN GP3A GRB1 GRB4 HEM1 HEM2 HSP27 HSP28 HSP90A HSP90AA1 HSPB1 HSPC1 HSPCA ITGAV ITGB3 KDR KIAA0068 KIAA0269 KIAA0281 KIAA0587 KIAA0619 KIAA0900 KIAA1168 KIAA1834 MAPK11 MAPK12 MAPK13 MAPK14 MAPKAPK2 MAPKAPK3 MSK8 MXI2 NAP1 NCF1 NCF2 NCF4 NCK NCK1 NCK2 NCKAP1 NCKAP1L NOX2 NOXA2 NOXO2 P67PHOX PAK2 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PIR121 PKACA PRKACA PRKACB PRKACG PRKM11 PRKM13 PTK2 PTK2B PXN PYK2 RAC1 RAFTK RHO12 RHOA ROCK1 ROCK2 SAPK2 SAPK2A SAPK2B SAPK3 SAPK4 SCAP SCAR1 SCAR3 SCK SH2D2A SH3PXD1A SH3PXD4 SHB SHC2 SHCB SSH3BP1 TC25 TSAD UFO VAV VAV1 VAV2 VAV3 VEGFR2 VNRA VRAP VTNR WASF1 WASF2 WASF3 WAVE1 WAVE2 WAVE3	Homo sapiens (human)
Tie2 Signaling	Angiopoietin-1 receptor Angiopoietin-1 Angiopoietin-2 Angiopoietin-4 Docking protein 2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 14 Growth factor receptor-bound protein 7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform SHC-transforming protein 1 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	O00459 O15123 O60496 P01111 P01112 P27986 P29353 P42336 P42338 Q02763 Q06124 Q07889 Q14449 Q14451 Q15389 Q9Y264	ANG3 ANG4 ANGPT1 ANGPT2 ANGPT4 DOK2 GRB1 GRB14 GRB7 HRAS HRAS1 KIAA0003 NRAS PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PTP2C PTPN11 SHC SHC1 SHCA SHPTP2 SOS1 TEK TIE2 VMCM VMCM1	Homo sapiens (human)
Signaling by SCF-KIT	Chymase GRB2-associated-binding protein 2 GRB2-related adapter protein 2 GRB2-related adapter protein GTPase HRas GTPase NRas Growth factor receptor-bound protein 10 Growth factor receptor-bound protein 7 Mast/stem cell growth factor receptor Kit Matrix metalloproteinase-9 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Protein kinase C alpha type Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Receptor-type tyrosine-protein phosphatase U Serine/threonine-protein kinase Chk1 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Son of sevenless homolog 1 Tyrosine-protein kinase Fer Tyrosine-protein kinase Fes/Fps Tyrosine-protein kinase Fyn Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase Tec Tyrosine-protein kinase Yes Tyrosine-protein phosphatase non-receptor type 11	O00459 O14757 O60674 O75791 P01111 P01112 P06239 P06241 P07332 P07947 P07948 P10721 P14780 P15498 P16591 P17252 P23946 P27986 P40763 P42224 P42229 P42336 P42680 P51692 P63000 Q06124 Q07889 Q13322 Q13588 Q14451 Q92569 Q92729 Q9UQC2	APRF CHEK1 CHK1 CLG4B CMA1 CYH CYM FER FES FMI FPS FYN GAB2 GADS GRAP GRAP2 GRB1 GRB10 GRB2L GRB7 GRBIR GRID HRAS HRAS1 JAK2 JTK8 KIAA0207 KIAA0571 KIT LCK LYN MMP9 NRAS PCP2 PIK3CA PIK3R1 PIK3R2 PIK3R3 PKCA PRKACA PRKCA PSCTK4 PTP2C PTPN11 PTPRO PTPRU RAC1 SCFR SHPTP2 SOS1 STAT1 STAT3 STAT5 STAT5A STAT5B TC25 TEC TYK3 VAV VAV1 YES YES1	Homo sapiens (human)
Interleukin-7 signaling	Bromodomain and WD repeat-containing protein 1 Cytokine receptor common subunit gamma Cytokine receptor-like factor 2 Cytokine-inducible SH2-containing protein Hepatocyte growth factor Histone H3.1 Histone H3.2 Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-7 receptor subunit alpha Interleukin-7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 2 Thymic stromal lymphopoietin Transcription activator BRG1 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK3 V(D)J recombination-activating protein 1 V(D)J recombination-activating protein 2	O00459 O14508 O15524 P13232 P14210 P15918 P16871 P23458 P27986 P31785 P35568 P40763 P42229 P51532 P51692 P52333 P55895 P68431 Q71DI3 Q92569 Q969D9 Q9HC73 Q9NSE2 Q9NSI6 Q9Y4H2	APRF BAF190A BRG1 BRWD1 C21orf107 CIS2 CISH CRL2 CRLF2 G18 GRB1 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM HGF HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST2H3A HIST2H3C HIST2H3D HPTA IL2RG IL7 IL7R ILXR IRS1 IRS2 JAK1 JAK1A JAK1B JAK3 PIK3R1 PIK3R2 PIK3R3 RAG1 RAG2 RNF74 SMARCA4 SNF2B SNF2L4 SOCS1 SOCS2 SSI1 SSI2 STAT3 STAT5 STAT5A STAT5B STATI2 TIP3 TSLP TSLPR WDR9	Homo sapiens (human)
RAF/MAP kinase cascade	Alpha-actinin-2 Amphiregulin Angiopoietin-1 receptor Angiopoietin-1 Artemin Astrocytic phosphoprotein PEA-15 Beta-klotho Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Cytokine receptor common subunit beta Cytokine receptor common subunit gamma Disks large homolog 1 Disks large homolog 2 Disks large homolog 3 Disks large homolog 4 Epidermal growth factor receptor Epigen Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Fms-related tyrosine kinase 3 ligand Focal adhesion kinase 1 GDNF family receptor alpha-1 GDNF family receptor alpha-2 GDNF family receptor alpha-3 GDNF family receptor alpha-4 GTPase HRas GTPase NRas Glial cell line-derived neurotrophic factor Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic, NMDA 2D Granulocyte-macrophage colony-stimulating factor receptor subunit alpha Granulocyte-macrophage colony-stimulating factor Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 Interleukin-3 receptor subunit alpha Interleukin-3 Interleukin-5 receptor subunit alpha Interleukin-5 Leucine-rich repeat-containing protein 7 Mast/stem cell growth factor receptor Kit Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Neural cell adhesion molecule 1 Neurofilament light polypeptide Neurturin Persephin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase receptor Ret Protransforming growth factor alpha RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 4 Ral guanine nucleotide dissociation stimulator-like 1 Ral guanine nucleotide dissociation stimulator-like 2 Ral guanine nucleotide dissociation stimulator-like 3 Ral guanine nucleotide dissociation stimulator Ran-binding protein 9 Rap guanine nucleotide exchange factor 2 Ras guanyl-releasing protein 3 Ras-GEF domain-containing family member 1A Ras-specific guanine nucleotide-releasing factor 1 Ras-specific guanine nucleotide-releasing factor 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Receptor-type tyrosine-protein phosphatase alpha SHC-transforming protein 1 SHC-transforming protein 2 SHC-transforming protein 3 Son of sevenless homolog 1 Spectrin alpha chain, erythrocytic 1 Spectrin alpha chain, non-erythrocytic 1 Spectrin beta chain, erythrocytic Spectrin beta chain, non-erythrocytic 1 Spectrin beta chain, non-erythrocytic 2 Spectrin beta chain, non-erythrocytic 4 Spectrin beta chain, non-erythrocytic 5 Tyrosine-protein kinase Fyn Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3	O00451 O00459 O14511 O14827 O14944 O15020 O15211 O15399 O15520 O43320 O43559 O60542 O60609 O60674 O76093 O95267 O95750 P00533 P01111 P01112 P01127 P01133 P01135 P01589 P02549 P04141 P04626 P05113 P05230 P06241 P07196 P07949 P08581 P08620 P08700 P09038 P09619 P0DP23 P10721 P10767 P11277 P11487 P13591 P14210 P14784 P15509 P15514 P16234 P18433 P21781 P22455 P23458 P26951 P27361 P27986 P28482 P29353 P31371 P31785 P32927 P35070 P35568 P35609 P36888 P39905 P42336 P42338 P49771 P52333 P56159 P56975 P60568 P78352 P98077 Q01082 Q01344 Q02297 Q02763 Q05397 Q05586 Q07889 Q12959 Q12967 Q13224 Q13554 Q13555 Q13557 Q13813 Q13972 Q15121 Q15389 Q15700 Q3MIN7 Q5T4W7 Q6UW88 Q86Z14 Q8IV61 Q8N9B8 Q8TDF6 Q8WU20 Q8WWG1 Q92529 Q92796 Q96NW7 Q96S59 Q99075 Q99748 Q9GZV9 Q9GZZ7 Q9H254 Q9HCT0 Q9NP95 Q9NRC6 Q9NZL6 Q9UQM7 Q9Y4G8 Q9Y4H2	ACTN2 ANGPT1 AREG AREGB ARTN BSPECV BTC CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CD135 CDC25 CDHF12 CDHR16 CSF2 CSF2R CSF2RA CSF2RB CSF2RY DLG1 DLG2 DLG3 DLG4 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ERK1 ERK2 EVN FAK FAK1 FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 FRS3 FYN GDNF GDNFRA GDNFRB GFRA1 GFRA2 GFRA3 GFRA4 GGF GMCSF GNRP GRB1 GRF1 GRF2 GRIN1 GRIN2B GRIN2D GRP3 GluN2D HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRAS HRAS1 HRGA HST HST2 HSTF1 HSTF2 HUBSPECV HUSPECV HYPF IL15RB IL2 IL2RA IL2RB IL2RG IL3 IL3R IL3RA IL3RB IL5 IL5R IL5RA IL5RB INT2 IRS1 IRS2 JAK1 JAK1A JAK1B JAK2 JAK3 JTK2 KGF KIAA0003 KIAA0302 KIAA0313 KIAA0846 KIAA0959 KIAA0968 KIAA1232 KIAA1308 KIAA1365 KIAA1642 KIT KLB KS3 LAP1 LRRC7 MAPK1 MAPK3 MET MLN19 NCAM NCAM1 NDF NEAS NEFL NEU NF68 NFL NGL NMDAR1 NMDAR2B NMDAR2D NRAPGEP NRAS NRG1 NRG2 NRG3 NRG4 NRTN NSHC NTAK PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PDZGEF1 PEA15 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PRKM1 PRKM2 PRKM3 PSD95 PSPN PTC PTK2 PTPA PTPRA PTPRL2 RAB2L RALGDS RANBP9 RANBPM RAPGEF2 RASGEF1A RASGRF1 RASGRF2 RASGRP RASGRP1 RASGRP3 RASGRP4 RET RETL1 RETL2 RGF RGL RGL1 RGL2 RGL3 RHEPDGFRA SCA5 SCFR SCK SDGF SHC SHC1 SHC2 SHC3 SHCA SHCB SHCC SIS SMDF SOS1 SPTA SPTA1 SPTA2 SPTAN1 SPTB SPTB1 SPTB2 SPTBN1 SPTBN2 SPTBN3 SPTBN4 SPTBN5 STK1 TEK TGFA TIE2 TKF TRNR1 TRNR2 VMCM VMCM1	Homo sapiens (human)
Regulation of insulin secretion	ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 11 Guanine nucleotide-binding protein G(i) subunit alpha-1 Guanine nucleotide-binding protein G(i) subunit alpha-2 Inositol 1,4,5-trisphosphate receptor type 2 Inositol 1,4,5-trisphosphate receptor type 3 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Insulin Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 S-adenosylhomocysteine hydrolase-like protein 1 Solute carrier family 2, facilitated glucose transporter member 1 Solute carrier family 2, facilitated glucose transporter member 2 Synaptosomal-associated protein 25 Synaptotagmin-5 Syntaxin-1A Syntaxin-binding protein 1 Vesicle-associated membrane protein 2 Voltage-dependent L-type calcium channel subunit alpha-1C Voltage-dependent L-type calcium channel subunit alpha-1D Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent L-type calcium channel subunit beta-3 Voltage-dependent P/Q-type calcium channel subunit alpha-1A Voltage-dependent R-type calcium channel subunit alpha-1E Voltage-dependent calcium channel subunit alpha-2/delta-2 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	O00445 O00555 O43865 O95398 P01308 P04899 P11166 P11168 P17612 P22612 P22694 P54284 P60880 P61764 P63027 P63096 Q01668 Q08289 Q09428 Q13936 Q14571 Q14573 Q14643 Q14654 Q15878 Q16623 Q8WZA2 Q9NY47	ABCC8 AHCYL1 CACH2 CACH3 CACH4 CACH6 CACN2 CACN3 CACN4 CACNA1A CACNA1C CACNA1D CACNA1E CACNA2D2 CACNB2 CACNB3 CACNL1A1 CACNL1A2 CACNL1A4 CACNL1A6 CACNLB2 CACNLB3 CCHL1A1 CCHL1A2 CGEF1 CGEF2 DCAL EPAC EPAC1 EPAC2 GLUT1 GLUT2 GNAI1 GNAI2 GNAI2B HRINS INS INSP3R1 IRBIT ITPR1 ITPR2 ITPR3 KCNJ11 KIAA0558 MYSB PKACA PRKACA PRKACB PRKACG RAPGEF3 RAPGEF4 SLC2A1 SLC2A2 SNAP SNAP25 STX1 STX1A STXBP1 SUR SUR1 SYB2 SYT5 UNC18A VAMP2 XPVKONA	Homo sapiens (human)	G58161NS

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